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12-O-Tetradecanoylphorbol-13-acetate

Index 12-O-Tetradecanoylphorbol-13-acetate

12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA), is a diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). [1]

25 relations: Cancer, Cancer Research (journal), Chronic lymphocytic leukemia, Clinical trial, Croton (plant), Cytogenetics, Diglyceride, Enzyme, Hematology, Ionomycin, Journal of Biological Chemistry, Journal of Immunology, Kaposi's sarcoma-associated herpesvirus, Medication, Mitogen, Phorbol, PLOS One, Proceedings of the National Academy of Sciences of the United States of America, Protein kinase C, Reactive oxygen species, Signal transduction, Small molecule, Superoxide, Toxicodendron radicans, Tumor promotion.

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cancer Research (journal)

Cancer Research is a peer-reviewed scientific journal published by the American Association for Cancer Research.

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Chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Croton (plant)

Croton is an extensive flowering plant genus in the spurge family, Euphorbiaceae.

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Cytogenetics

Cytogenetics is a branch of genetics that is concerned with how the chromosomes relate to cell behaviour, particularly to their behaviour during mitosis and meiosis.

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Diglyceride

A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Hematology

Hematology, also spelled haematology, is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood.

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Ionomycin

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus.

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Journal of Biological Chemistry

The Journal of Biological Chemistry is a weekly peer-reviewed scientific journal that was established in 1905.

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Journal of Immunology

The Journal of Immunology is a twice monthly peer-reviewed academic journal that publishes basic and clinical studies in all aspects of immunology.

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Kaposi's sarcoma-associated herpesvirus

Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus; its formal name according to the International Committee on Taxonomy of Viruses (ICTV) is HHV-8.

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Medication

A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Mitogen

A mitogen is a chemical substance that encourages a cell to commence cell division, triggering mitosis.

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Phorbol

Phorbol is a natural, plant-derived organic compound.

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PLOS One

PLOS One (stylized PLOS ONE, and formerly PLoS ONE) is a peer-reviewed open access scientific journal published by the Public Library of Science (PLOS) since 2006.

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America (PNAS) is the official scientific journal of the National Academy of Sciences, published since 1915.

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Protein kinase C

Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

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Small molecule

Within the fields of molecular biology and pharmacology, a small molecule is a low molecular weight (< 900 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm.

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Superoxide

A superoxide is a compound that contains the superoxide anion, which has the chemical formula.

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Toxicodendron radicans

Toxicodendron radicans, commonly known as eastern poison ivy or poison ivy, is a poisonous Asian and Eastern North American flowering plant that is well-known for causing urushiol-induced contact dermatitis, an itchy, irritating, and sometimes painful rash, in most people who touch it.

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Tumor promotion

Tumor promotion is a process in carcinogenesis by which various factors permit the descendants of a single initiated cell to survive and expand in number, i.e. to resist apoptosis and to undergo clonal growth.

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Redirects here:

12-O-tetradecanoylphorbol-13-acetate, C36H56O8, Phorbol 12-myristate 13-acetate, Phorbol myristate acetate, Phorbol-12-myristate-13-acetate, Tetradecanoyl phorbol acetate, Tetradecanoylphorbol acetate, Tetraphorbal acetate.

References

[1] https://en.wikipedia.org/wiki/12-O-Tetradecanoylphorbol-13-acetate

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