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17β-Hydroxysteroid dehydrogenase

Index 17β-Hydroxysteroid dehydrogenase

17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism. [1]

61 relations: Adrenal cortex, AKR1C3, Alcohol oxidoreductase, Alzheimer's disease, Androstanediol, Androstanedione, Androstenediol, Androstenedione, Beta oxidation, Bile acid, Catalysis, Cell nucleus, Cytosol, D-bifunctional protein deficiency, Dehydroepiandrosterone, Dehydrogenation, Dihydrotestosterone, Endometriosis, Endosome, Estradiol, Estriol, Estrone, Fatty acid, Fisetin, HSD17B1, HSD17B10, HSD17B11, HSD17B12, HSD17B13, HSD17B14, HSD17B2, HSD17B3, HSD17B4, HSD17B6, HSD17B7, HSD17B8, Hydroxysteroid, Intellectual disability, Isoleucine, Ketosteroid, Metabolism, Neurodegeneration, Neurosteroid, Osteoporosis, Polycystic kidney disease, Progesterone, RDH5, Redox, Retinitis pigmentosa, Retinoid, ..., Steroid, Steroidogenic enzyme, Testosterone, White dot syndromes, Xenobiotic, XX gonadal dysgenesis, 16α-Hydroxyestrone, 17β-Hydroxysteroid dehydrogenase III deficiency, 20α-Dihydroprogesterone, 3α-Androstanediol, 3β-Androstanediol. Expand index (11 more) »

Adrenal cortex

Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, such as aldosterone and cortisol, respectively.

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AKR1C3

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.

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Alcohol oxidoreductase

Alcohol oxidoreductases are oxidoreductase enzymes that act upon an alcohol functional group.

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Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Androstanediol

Androstanediol may refer to.

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Androstanedione

Androstanediones are a pair of isomeric steroids which differ at the 5-position.

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Androstenediol

Androstenediol, or 5-androstenediol (abbreviated as A5 or Δ5-diol), also known as androst-5-ene-3β,17β-diol, is an endogenous weak androgen and estrogen steroid hormone and intermediate in the biosynthesis of testosterone from dehydroepiandrosterone (DHEA).

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Androstenedione

Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA).

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Beta oxidation

In biochemistry and metabolism, beta-oxidation is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA, which enters the citric acid cycle, and NADH and FADH2, which are co-enzymes used in the electron transport chain.

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Bile acid

Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates.

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Catalysis

Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Cytosol

The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

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D-bifunctional protein deficiency

D-Bifunctional protein deficiency (officially called 17β-hydroxysteroid dehydrogenase IV deficiency) is an autosomal recessive peroxisomal fatty acid oxidation disorder.

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Dehydroepiandrosterone

Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone.

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Dehydrogenation

Dehydrogenation is a chemical reaction that involves the removal of hydrogen from an organic molecule.

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Dihydrotestosterone

Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone.

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Endometriosis

Endometriosis is a condition in which the endometrium, the layer of tissue that normally covers the inside of the uterus, grows outside of it.

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Endosome

In cell biology, an endosome is a membrane-bound compartment inside eukaryotic cells.

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Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.

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Estriol

Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone.

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Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone.

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Fatty acid

In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with a long aliphatic chain, which is either saturated or unsaturated.

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Fisetin

Fisetin (7,3′,4′-flavon-3-ol), is a plant polyphenol from the flavonoid group.

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HSD17B1

17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene.

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HSD17B10

17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial enzyme that in humans is encoded by the HSD17B10 (hydroxysteroid (17β) dehydrogenase 10) gene.

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HSD17B11

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.

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HSD17B12

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.

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HSD17B13

17β-Hydroxysteroid dehydrogenase type 13 also known as 17β-HSD type 13 is an enzyme that in humans is encoded by the HSD17B13 gene.

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HSD17B14

17β-Hydroxysteroid dehydrogenase type 14 also known as 17β-HSD type 14 or 17βHSD14 is an enzyme that in humans is encoded by the HSD17B14 gene.

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HSD17B2

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2 gene.

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HSD17B3

17β-Hydroxysteroid dehydrogenase 3 (17β-HSD3) is an enzyme that in humans is encoded by the HSD17B3 gene and is involved in androgen steroidogenesis.

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HSD17B4

D-bifunctional protein (DBP), also known as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV (17β-HSD type IV) is a protein that in humans is encoded by the HSD17B4 gene.

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HSD17B6

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene.

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HSD17B7

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.

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HSD17B8

Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.

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Hydroxysteroid

A hydroxysteroid is a molecule derived from a steroid with a hydrogen replaced with a hydroxy group.

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Intellectual disability

Intellectual disability (ID), also known as general learning disability, and mental retardation (MR), is a generalized neurodevelopmental disorder characterized by significantly impaired intellectual and adaptive functioning.

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Isoleucine

Isoleucine (symbol Ile or I) is an α-amino acid that is used in the biosynthesis of proteins.

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Ketosteroid

Androstenedione Androsterone Estrone A ketosteroid, or an oxosteroid, is a steroid in which a hydrogen atom has been replaced with a ketone (C.

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Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Neurodegeneration

Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.

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Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.

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Osteoporosis

Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone.

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Polycystic kidney disease

Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidney.

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Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

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RDH5

11-cis retinol dehydrogenase is an enzyme that in humans is encoded by the RDH5 gene.

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Retinitis pigmentosa

Retinitis pigmentosa (RP) is a genetic disorder of the eyes that causes loss of vision.

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Retinoid

The retinoids are a class of chemical compounds that are vitamers of vitamin A or are chemically related to it.

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Steroid

A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.

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Steroidogenic enzyme

Steroidogenic enzymes, or steroid-metabolizing enzymes, are enzymes that are involved in steroidogenesis and steroid metabolism.

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Testosterone

Testosterone is the primary male sex hormone and an anabolic steroid.

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White dot syndromes

White dot syndromes are inflammatory diseases characterized by the presence of white dots on the fundus, the interior surface of the eye.

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Xenobiotic

A xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism.

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XX gonadal dysgenesis

This syndrome is inherited as an autosomal disease.

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16α-Hydroxyestrone

16α-Hydroxyestrone (16α-OH-E1), or hydroxyestrone, also known as estra-1,3,5(10)-trien-3,16α-diol-17-one, is an endogenous steroidal estrogen and a major metabolite of estrone, as well as an intermediate in the biosynthesis of estriol.

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17β-Hydroxysteroid dehydrogenase III deficiency

17β-Hydroxysteroid dehydrogenase III deficiency is a rare disorder of sexual development, or intersex condition, affecting testosterone biosynthesis by 17β-hydroxysteroid dehydrogenase III (17β-HSD III), which can produce impaired virilization (historically termed male pseudohermaphroditism) of genetically male infants.

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20α-Dihydroprogesterone

20α-Dihydroprogesterone (20α-DHP), also known as 20α-hydroxyprogesterone (20α-OHP), is a naturally occurring, endogenous progestogen.

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3α-Androstanediol

3α-Androstanediol (often abbreviated as 3α-diol), also known as 5α-androstane-3α,17β-diol, is an endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT).

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3β-Androstanediol

3β-Androstanediol, also known as 5α-androstane-3β,17β-diol, and often shortened to 3β-diol, is an endogenous steroid hormone.

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Redirects here:

17-KSR, 17-KSRs, 17-Ketoreductase, 17-Ketoreductases, 17-Ketosteroid oxidoreductase, 17-Ketosteroid oxidoreductases, 17-Ketosteroid reductase, 17-Ketosteroid reductases, 17-beta-hydroxysteroid dehydrogenase isozyme 3, 17-ketoreductase, 17-ketoreductases, 17-ketosteroid oxidoreductase, 17-ketosteroid oxidoreductases, 17-ketosteroid reductase, 17-ketosteroid reductases, 17B-HSD, 17BHSD3, 17Beta Hydroxysteroid dehydrogenase, 17b-Hydroxysteroid dehydrogenase, 17b-hydroxysteroid dehydrogenase, 17bHydroxysteroid-Dehydrogenase, 17β hydroxysteroid dehydrogenase, 17β-HSD, 17β-HSDs, 17β-Hydroxysteroid dehydrogenases, 17β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenases, 3(or 17)b-hydroxysteroid dehydrogenase, 3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase, EC 1.1.1.51, HSD17B, HSD17B*, HSD17Bs.

References

[1] https://en.wikipedia.org/wiki/17β-Hydroxysteroid_dehydrogenase

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