18-Hydroxy-11-deoxycorticosterone

18-Hydroxy-11-deoxycorticosterone (also known as 18-OH-DOC, 18,21-dihydroxyprogesterone, and 18,21-dihydroxypregn-4-ene-3,20-dione) is an endogenous steroid and a mineralocorticoid. ^[1]

11 relations: Aldosterone synthase, CYP11B3, CYP17A1, Endogeny (biology), Human, Metabolite, Mineralocorticoid, Primary aldosteronism, Rat, Steroid, 11-Deoxycorticosterone.
Mineralocorticoids
Steroid hormones

Aldosterone synthase

Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids.

See 18-Hydroxy-11-deoxycorticosterone and Aldosterone synthase

CYP11B3

The Cyp11b3 is a rat gene encoding a CYP450 enzyme, which is mainly expressed in neonatal rat adrenals, and also expressed in a small amount in other organs of adult rats, this enzyme mainly catalyzing 11-Deoxycorticosterone (DOC) to 18-Hydroxy-11-deoxycorticosterone (18-OH-DOC).

See 18-Hydroxy-11-deoxycorticosterone and CYP11B3

CYP17A1

Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

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Human

Humans (Homo sapiens, meaning "thinking man") or modern humans are the most common and widespread species of primate, and the last surviving species of the genus Homo.

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Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

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Mineralocorticoid

Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones. 18-Hydroxy-11-deoxycorticosterone and Mineralocorticoid are mineralocorticoids.

See 18-Hydroxy-11-deoxycorticosterone and Mineralocorticoid

Primary aldosteronism

Primary aldosteronism (PA), also known as primary hyperaldosteronism, refers to the excess production of the hormone aldosterone from the adrenal glands, resulting in low renin levels and high blood pressure.

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Rat

Rats are various medium-sized, long-tailed rodents.

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Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

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11-Deoxycorticosterone

11-Deoxycorticosterone (DOC), or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, as well as desoxycortone (INN), deoxycortone, and cortexone, is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. 18-Hydroxy-11-deoxycorticosterone and 11-Deoxycorticosterone are mineralocorticoids and steroid hormones.

See 18-Hydroxy-11-deoxycorticosterone and 11-Deoxycorticosterone

References

[1] https://en.wikipedia.org/wiki/18-Hydroxy-11-deoxycorticosterone

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