18-Oxocortisol

18-Oxocortisol is an endogenous steroid, a metabolite of cortisol. ^[1]

ACTH stimulation test

The ACTH test (also called the cosyntropin, tetracosactide, or Synacthen test) is a medical test usually requested and interpreted by endocrinologists to assess the functioning of the adrenal glands' stress response by measuring the adrenal response to adrenocorticotropic hormone (ACTH; corticotropin) or another corticotropic agent such as tetracosactide (cosyntropin, tetracosactrin; Synacthen) or alsactide (Synchrodyn).

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Adenoma

An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or both.

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Adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.

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Aldosterone

Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. 18-Oxocortisol and Aldosterone are mineralocorticoids and Pregnanes.

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Aldosterone synthase

Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids.

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Biosynthesis

Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

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Cav1.3

Calcium channel, voltage-dependent, L type, alpha 1D subunit (also known as Cav1.3) is a protein that in humans is encoded by the CACNA1D gene.

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Cortisol

Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone. 18-Oxocortisol and Cortisol are Pregnanes and steroids.

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Crossover (genetic algorithm)

In genetic algorithms and evolutionary computation, crossover, also called recombination, is a genetic operator used to combine the genetic information of two parents to generate new offspring.

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Dexamethasone

Dexamethasone is a fluorinated glucocorticoid medication used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, superior vena cava syndrome (a complication of some forms of cancer), and along with antibiotics in tuberculosis. 18-Oxocortisol and Dexamethasone are Pregnanes.

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Disease

A disease is a particular abnormal condition that adversely affects the structure or function of all or part of an organism and is not immediately due to any external injury.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

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Excretion

Excretion is elimination of metabolic waste, which is an essential process in all organisms.

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Familial hyperaldosteronism

Familial hyperaldosteronism is a group of inherited conditions in which the adrenal glands, which are small glands located on top of each kidney, produce too much of the hormone aldosterone.

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Glucocorticoid

Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones.

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Hyperaldosteronism

Hyperaldosteronism is a medical condition wherein too much aldosterone is produced.

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KCNJ5

G protein-activated inward rectifier potassium channel 4 (GIRK-4) is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.

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Mineralocorticoid

Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones. 18-Oxocortisol and Mineralocorticoid are mineralocorticoids.

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Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. 18-Oxocortisol and steroid are steroids.

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Steroid 11β-hydroxylase

Steroid 11β-hydroxylase, also known as steroid 11β-monooxygenase, is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata of the adrenal cortex.

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Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

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Zona fasciculata

The zona fasciculata (sometimes, fascicular or fasciculate zone) constitutes the middle and also the widest zone of the adrenal cortex, sitting directly beneath the zona glomerulosa.

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18-Hydroxycorticosterone

18-Hydroxycorticosterone is an endogenous steroid. 18-Oxocortisol and 18-Hydroxycorticosterone are Pregnanes.

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18-Hydroxycortisol

18-Hydroxycortisol is an endogenous steroid, a metabolite of cortisol. 18-Oxocortisol and 18-Hydroxycortisol are Pregnanes and steroids.

See 18-Oxocortisol and 18-Hydroxycortisol

6β-Hydroxycortisol

6β-Hydroxycortisol is an endogenous steroid. 18-Oxocortisol and 6β-Hydroxycortisol are Pregnanes and steroids.

See 18-Oxocortisol and 6β-Hydroxycortisol

References

[1] https://en.wikipedia.org/wiki/18-Oxocortisol

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