41 relations: ABHD12, ABHD6, Agonist, Anandamide, Arachidonic acid, Biochemical and Biophysical Research Communications, Biochemical Pharmacology (journal), Biosynthesis, Breast milk, British Journal of Pharmacology, Cannabinoid receptor type 1, Diacylglycerol lipase, Diglyceride, Endocannabinoid system, Endocannabinoid transporter, Endogeny (biology), Ester, Fatty acid amide hydrolase, Fatty acid-binding protein, Georgetown, Texas, Glycerol, Heat shock protein, Hebrew University of Jerusalem, Hsp70, Hydrolysis, Lipid signaling, Lysophosphatidic acid, Metabolism, Monoacylglycerol lipase, Nervous system, Neuroblastoma, Omega-6 fatty acid, Phosphatase, Phosphatidic acid, Phosphatidylcholine, Phospholipase C, Raphael Mechoulam, Serine hydrolase, Springer Science+Business Media, Teikyo University, 2-Arachidonyl glyceryl ether.
alpha/beta-Hydrolase domain containing 12 (ABHD12) is a serine hydrolase encoded by the ABHD12 gene that participates in the breakdown of the endocannabinoid neurotransmitter 2-arachidonylglycerol (2-AG) in the central nervous system.
alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 gene.
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
Anandamide, also known as N-arachidonoylethanolamine or AEA, is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid) an essential ω-6 polyunsaturated fatty acid.
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).
Biochemical and Biophysical Research Communications is a weekly peer-reviewed scientific journal covering all aspects of biochemistry and biophysics.
Biochemical Pharmacology is a peer-reviewed medical journal published by Elsevier.
Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.
Breast milk is the milk produced by the breasts (or mammary glands) of a human female to feed a child.
The British Journal of Pharmacology is a biweekly peer-reviewed medical journal covering all aspects of experimental pharmacology.
The cannabinoid type 1 receptor, often abbreviated as CB1, is a G protein-coupled cannabinoid receptor located in the central and peripheral nervous system.
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages.
The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system.
The endocannabinoid transporters (eCBTs) are transport proteins for the endocannabinoids.
Endogenous substances and processes are those that originate from within an organism, tissue, or cell.
In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.
Fatty acid amide hydrolase or FAAH (oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes.
The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids.
Georgetown is a city in and the county seat of Williamson County, Texas, United States, with a population of 47,400 at the 2010 census and a population of 63,716 at the 2016 Census estimate.
Glycerol (also called glycerine or glycerin; see spelling differences) is a simple polyol compound.
Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions.
The Hebrew University of Jerusalem (האוניברסיטה העברית בירושלים, Ha-Universita ha-Ivrit bi-Yerushalayim; الجامعة العبرية في القدس, Al-Jami'ah al-Ibriyyah fi al-Quds; abbreviated HUJI) is Israel's second oldest university, established in 1918, 30 years before the establishment of the State of Israel.
The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins.
Hydrolysis is a term used for both an electro-chemical process and a biological one.
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses.
Lysophosphatidic acid (LPA) is a phospholipid derivative that can act as a signaling molecule.
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
Monoacylglycerol lipase, also known as MAG lipase, MAGL, MGL or MGLL is a protein that, in humans, is encoded by the MGLL gene.
The nervous system is the part of an animal that coordinates its actions by transmitting signals to and from different parts of its body.
Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands, but can also develop in the neck, chest, abdomen, or spine. Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin. Occasionally, neuroblastoma may be due to a mutation inherited from a person's parents. Environmental factors have not been found to be involved. Diagnosis is based on a tissue biopsy. Occasionally it may be found in a baby by ultrasound during pregnancy. At diagnosis, the cancer has usually already spread. The cancer is divided into low-, intermediate-, and high-risk groups based on a child's age, cancer stage, and what the cancer looks like. Treatment and outcomes depends on the risk group a person is in. Treatments may include observation, surgery, radiation, chemotherapy, or stem cell transplantation. Low-risk disease in babies typically has a good outcome with surgery or simply observation. In high-risk disease, chances of long-term survival, however, are less than 40% despite aggressive treatment. Neuroblastoma is the most common cancer in babies and the third-most common cancer in children after leukemia and brain cancer. About one in every 7,000 children is affected at some time. About 90% of cases occur in children less than 5 years old and it is rare in adults. Of cancer deaths in children, about 15% are due to neuroblastoma. The disease was first described in the 1800s.
Omega-6 fatty acids (also referred to as ω-6 fatty acids or n-6 fatty acids) are a family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the ''n''-6 position, that is, the sixth bond, counting from the methyl end.
A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol.
Phosphatidic acids are phospholipids which on hydrolysis give rise to one molecule of glycerol and phosphoric acid and two molecules of fatty acids.
Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup.
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).
Raphael Mechoulam (רפאל משולם) (born 1930) is an Israeli organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel.
Serine hydrolases are one of the largest known enzyme classes comprising approximately ~200 enzymes or 1% of the genes in the human proteome.
Springer Science+Business Media or Springer, part of Springer Nature since 2015, is a global publishing company that publishes books, e-books and peer-reviewed journals in science, humanities, technical and medical (STM) publishing.
is a private university headquartered in the Itabashi ward of Tokyo, Japan.
2-Arachidonyl glyceryl ether (2-AGE, Noladin ether) is a putative endocannabinoid discovered by Lumír Hanuš and colleagues at the Hebrew University of Jerusalem, Israel.