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2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

Index 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase

In enzymology, SEPHCHC synthase (EC), encoded by menD gene in E. coli, is an enzyme that catalyzes the second step of menaquinone (vitamin K2) biosynthesis. [1]

12 relations: Aldehyde, Alpha-Ketoglutaric acid, Bacillus subtilis, Enzyme, Enzyme Commission number, Escherichia coli, Ketone, Mycobacterium tuberculosis, Pyruvic acid, Transketolase, Vitamin K2, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.

Aldehyde

An aldehyde or alkanal is an organic compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen and to an R group, which is any generic alkyl or side chain.

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Alpha-Ketoglutaric acid

α-Ketoglutaric acid (2-oxoglutaric acid) is one of two ketone derivatives of glutaric acid.

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Bacillus subtilis

Bacillus subtilis, known also as the hay bacillus or grass bacillus, is a Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants and humans.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Enzyme Commission number

The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze.

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Escherichia coli

Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).

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Ketone

In chemistry, a ketone (alkanone) is an organic compound with the structure RC(.

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Mycobacterium tuberculosis

Mycobacterium tuberculosis is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis.

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Pyruvic acid

Pyruvic acid (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group.

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Transketolase

Transketolase encoded by the TKT gene is an enzyme of both the pentose phosphate pathway in all organisms and the Calvin cycle of photosynthesis.

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Vitamin K2

Vitamin K2 or menaquinone has nine related compounds, generally subdivided into the short-chain menaquinones (with MK-4 as the most important member) and the long-chain menaquinones, of which MK-7, MK-8 and MK-9 are nutritionally the most recognized.

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2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, also known as SHCHC synthase, is encoded by the menH gene in E.coli and functions in the synthesis of vitamin K. The specific step in the synthetic pathway that SHCHC synthase catalyzes is the conversion of 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate to (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate and pyruvate.

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Redirects here:

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase, EC 2.2.1.9, Isochorismate:2-oxoglutarate 4-oxopentanoatetransferase (decarboxylating), SEPHCHC synthase.

References

[1] https://en.wikipedia.org/wiki/2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid_synthase

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