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13 relations: Adrenodoxin reductase, Calcifediol, Calcitriol, Cytochrome P450, Enzyme, Gene, Hydroxylation, Keratinocyte, Kidney, Matthew Kulke, Osteoblast, Proximal tubule, Vitamin D.
Adrenodoxin reductase
Adrenodoxin reductase (Enzyme Nomenclature name: adrenodoxin-NADP+ reductase, EC 1.18.1.6), was first isolated from bovine adrenal cortex where it functions as the first enzyme in the mitochondrial P450 systems that catalyze essential steps in steroid hormone biosynthesis.
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Calcifediol
Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick.
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Calcitriol
Calcitriol (INN), also called 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and other variants, is the hormonally active metabolite of vitamin D which has three hydroxyl groups.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Hydroxylation
Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.
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Keratinocyte
A keratinocyte is the predominant cell type in the epidermis, the outermost layer of the skin, constituting 90% of the cells found there.
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Matthew Kulke
Matthew Helmut Kulke is a Professor of Medicine at the Dana–Farber/Harvard Cancer Center.
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Osteoblast
Osteoblasts (from the Greek combining forms for "bone", ὀστέο-, osteo- and βλαστάνω, blastanō "germinate") are cells with a single nucleus that synthesize bone.
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Proximal tubule
The proximal tubule is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle.
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Vitamin D
Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects.
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1-α-hydroxylase, 1a-hydroxylase, 1α-hydroxylase, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, 25-hydroxyvitamin D3 1-alpha-hydroxylase, 25-hydroxyvitamin d3 1-alpha-hydroxylase, CYP27B1, CYP27B1 (gene), Calcidiol 1-monooxygenase, Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating), EC 1.14.13.13.
References
[1] https://en.wikipedia.org/wiki/25-Hydroxyvitamin_D3_1-alpha-hydroxylase
