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25I-NBOMe

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25I-NBOMe (2C-I-NBOMe, Cimbi-5, also shortened to "25I") is a psychedelic hallucinogen that is used in biochemistry research for mapping the brains usage of the type 2A serotonin receptor and later also has been used for recreational purpose. [1]

87 relations: Agonist, Alexander Shulgin, Alkylation, Alpha-1 adrenergic receptor, Analytical balance, Buccal administration, Cardiac arrest, Cork (city), David E. Nichols, Designer drug, Dissociation constant, Dopamine receptor D1, Dopamine receptor D2, Dopamine receptor D3, Dopamine receptor D5, Dopamine transporter, Drug checking, East Grand Forks, Minnesota, Ehrlich's reagent, Ergoline, Erowid, European Union, Free University of Berlin, Grand Forks, North Dakota, Hallucinogen, Head-twitch response, Histamine H1 receptor, Histamine H2 receptor, Histamine H3 receptor, Human, Hydrochloride, Imine, Inhalation, Insufflation (medicine), Intramuscular injection, Intravenous therapy, Ireland, Ischemia, Isotopic labeling, Δ-opioid receptor, Κ-opioid receptor, Μ-opioid receptor, Little Rock, Arkansas, Lysergic acid diethylamide, Medical Products Agency (Sweden), Microgram, Muscarinic acetylcholine receptor, Phenethylamine, Phospholipase A2, PiHKAL, ..., Positron emission tomography, Potency (pharmacology), Psychedelic drug, Purdue University, Radioactive tracer, Receptor (biochemistry), Rectal administration, Redox, Research chemical, Riksdag, Sense, Serotonin, Serotonin transporter, Sodium borohydride, Sodium triacetoxyborohydride, Sublabial administration, Sublingual administration, Substituted phenethylamine, Thrombosis, Thromboxane A2, Utility pole, WISH-TV, 2,5-Dimethoxy-4-iodoamphetamine, 25-NB, 2C (psychedelics), 2C-I, 5-HT1A receptor, 5-HT1B receptor, 5-HT1D receptor, 5-HT1E receptor, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT3 receptor, 5-HT5A receptor, 5-HT6 receptor, 5-HT7 receptor. Expand index (37 more) »

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Alexander Shulgin

Alexander Theodore "Sasha" Shulgin (June 17, 1925 June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author.

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Alkylation

Alkylation is the transfer of an alkyl group from one molecule to another.

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Alpha-1 adrenergic receptor

The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.

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Analytical balance

An analytical balance (often called a "lab balance") is a class of balance designed to measure small mass in the sub-milligram range.

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Buccal administration

Buccal administration refers to a topical route of administration by which drugs held or applied in the buccal area (in the cheek) diffuse through the oral mucosa (tissues which line the mouth) and enter directly into the bloodstream.

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Cardiac arrest

Cardiac arrest is a sudden loss of blood flow resulting from the failure of the heart to effectively pump.

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Cork (city)

Cork (from corcach, meaning "marsh") is a city in south-west Ireland, in the province of Munster, which had a population of 125,622 in 2016.

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David E. Nichols

David Earl Nichols (born December 23, 1944, Covington, Kentucky) is an American pharmacologist and medicinal chemist.

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Designer drug

A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests.

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Dissociation constant

In chemistry, biochemistry, and pharmacology, a dissociation constant (K_d) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its component ions.

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Dopamine receptor D1

Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.

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Dopamine receptor D2

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.

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Dopamine receptor D3

Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene.

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Dopamine receptor D5

Dopamine receptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene.

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Dopamine transporter

The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.

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Drug checking

Drug checking or pill testing is a way to reduce the harm from drug consumption by allowing users to find out the content and purity of substances that they intend to consume.

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East Grand Forks, Minnesota

East Grand Forks (also known as EGF) is a city in Polk County, Minnesota, United States.

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Ehrlich's reagent

Ehrlich's reagent or Ehrlich reagent is a reagent that contains ''p''-dimethylaminobenzaldehyde (DMAB) and thus can act as an indicator to presumptively identify indoles and urobilinogen.

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Ergoline

Ergoline derivatives comprise a diverse group of chemical compounds whose structural skeleton is the alkaloid ergoline.

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Erowid

Erowid, also called Erowid Center, is a 501(c)(3) non-profit educational organization that provides information about psychoactive plants and chemicals as well as activities and technologies that can produce altered states of consciousness such as meditation, lucid dreaming, transcranial magnetic stimulation, and electroceuticals.

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European Union

The European Union (EU) is a political and economic union of EUnum member states that are located primarily in Europe.

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Free University of Berlin

The Free University of Berlin (Freie Universität Berlin, often abbreviated as FU Berlin or simply FU) is a research university located in Berlin, Germany.

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Grand Forks, North Dakota

Grand Forks is the third-largest city in the state of North Dakota (after Fargo and Bismarck) and is the county seat of Grand Forks County.

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Hallucinogen

A hallucinogen is a psychoactive agent which can cause hallucinations, perceptual anomalies, and other substantial subjective changes in thoughts, emotion, and consciousness.

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Head-twitch response

The head-twitch response (HTR) is a rapid side-to-side head movement that occurs in mice and rats after the serotonin 5-HT2A receptor is activated.

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Histamine H1 receptor

The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.

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Histamine H2 receptor

H2 receptors are positively coupled to adenylate cyclase via Gs.

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Histamine H3 receptor

Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release.

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Human

Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.

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Hydrochloride

In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).

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Imine

An imine is a functional group or chemical compound containing a carbon–nitrogen double bond.

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Inhalation

Inhalation (also known as inspiration) happens when oxygen from the air enters the lungs.

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Insufflation (medicine)

Insufflation (lit) is the act of blowing something (such as a gas, powder, or vapor) into a body cavity.

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Intramuscular injection

Intramuscular (also IM or im) injection is the injection of a substance directly into muscle.

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Intravenous therapy

Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).

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Ireland

Ireland (Éire; Ulster-Scots: Airlann) is an island in the North Atlantic.

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Ischemia

Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).

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Isotopic labeling

Isotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation) through a reaction, metabolic pathway, or cell.

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Δ-opioid receptor

The δ-opioid receptor, also known as delta opioid receptor or simply delta receptor, abbreviated DOR, is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein Gi/G0 and has enkephalins as its endogenous ligands.

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Κ-opioid receptor

The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.

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Μ-opioid receptor

The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins.

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Little Rock, Arkansas

Little Rock is the capital and most populous city of the U.S. state of Arkansas.

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Lysergic acid diethylamide

Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects, which may include altered awareness of one's surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not.

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Medical Products Agency (Sweden)

The Medical Products Agency (Läkemedelsverket) is the government agency in Sweden responsible for regulation and surveillance of the development, manufacturing and sale of medicinal drugs, medical devices and cosmetics.

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Microgram

In the metric system, a microgram or microgramme (μg; the recommended symbol in the United States when communicating medical information is mcg) is a unit of mass equal to one millionth of a gram.

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Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.

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Phenethylamine

Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans.

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Phospholipase A2

Phospholipases A2 (PLA2s) are enzymes that release fatty acids from the second carbon group of glycerol.

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PiHKAL

PiHKAL: A Chemical Love Story is a book by Dr.

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Positron emission tomography

Positron-emission tomography (PET) is a nuclear medicine functional imaging technique that is used to observe metabolic processes in the body as an aid to the diagnosis of disease.

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Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

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Psychedelic drug

Psychedelics are a class of drug whose primary action is to trigger psychedelic experiences via serotonin receptor agonism, causing thought and visual/auditory changes, and altered state of consciousness.

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Purdue University

Purdue University is a public research university in West Lafayette, Indiana and is the flagship campus of the Purdue University system.

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Radioactive tracer

A radioactive tracer, or radioactive label, is a chemical compound in which one or more atoms have been replaced by a radionuclide so by virtue of its radioactive decay it can be used to explore the mechanism of chemical reactions by tracing the path that the radioisotope follows from reactants to products.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Rectal administration

Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels,The rectum has numerous blood vessels available to absorb drugs.

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Research chemical

Research chemicals are chemical substances used by scientists for medical and scientific research purposes.

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Riksdag

The Riksdag (riksdagen or Sveriges riksdag) is the national legislature and the supreme decision-making body of Sweden.

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Sense

A sense is a physiological capacity of organisms that provides data for perception.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Serotonin transporter

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.

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Sodium borohydride

Sodium borohydride, also known as sodium tetrahydridoborate and sodium tetrahydroborate, is an inorganic compound with the formula NaBH4.

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Sodium triacetoxyborohydride

Sodium triacetoxyborohydride, also known as sodium triacetoxyhydroborate, commonly abbreviated STAB, is a chemical compound with the formula Na(CH3COO)3BH.

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Sublabial administration

Sublabial administration, literally "under the lip", from Latin, refers to the pharmacological route of administration by which the active substance is placed between the lip and the gingiva (gum).

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Sublingual administration

Sublingual (abbreviated SL), from the Latin for "under the tongue", refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue.

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Substituted phenethylamine

Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents.

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Thrombosis

Thrombosis (from Ancient Greek θρόμβωσις thrómbōsis "clotting”) is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

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Thromboxane A2

Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation.

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Utility pole

A utility pole is a column or post used to support overhead power lines and various other public utilities, such as electrical cable, fiber optic cable, and related equipment such as transformers and street lights.

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WISH-TV

WISH-TV, virtual channel 8 (VHF digital channel 9), is a CW-affiliated television station licensed to Indianapolis, Indiana, United States.

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2,5-Dimethoxy-4-iodoamphetamine

2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug and a substituted amphetamine.

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25-NB

The 25-NB (25x-NBx) series, sometimes alternatively referred to as the NBOMe compounds, is a family of serotonergic psychedelics.

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2C (psychedelics)

2C (2C-x) is a general name for the family of psychedelic phenethylamines containing methoxy groups on the 2 and 5 positions of a benzene ring.

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2C-I

2C-I is a psychedelic phenethylamine of the 2C family.

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5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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5-HT1B receptor

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene.

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5-HT1D receptor

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.

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5-HT1E receptor

5-hydroxytryptamine (serotonin) 1E receptor (5-HT1E) is a highly expressed human G-protein coupled receptor that belongs to the 5-HT1 receptor family (Gi-coupled serotonin receptor).

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5-HT2A receptor

The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).

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5-HT2B receptor

5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.

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5-HT2C receptor

The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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5-HT3 receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.

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5-HT5A receptor

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.

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5-HT6 receptor

The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).

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5-HT7 receptor

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.

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Redirects here:

2C-I-NBOMe, BOM-CI, C18H22INO3, Cimbi-5, NBOMe-2C-I, NBOMe-2CI, NOBme.

References

[1] https://en.wikipedia.org/wiki/25I-NBOMe

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