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12 relations: Abiraterone, Abiraterone acetate, Active metabolite, Adjuvant therapy, Androgen, Dutasteride, Esterase, Δ4-Abiraterone, Prostate cancer, 3β-Hydroxysteroid dehydrogenase, 5α-Reductase, 5α-Reductase inhibitor.
Abiraterone
Abiraterone, developmental code name CB-7598, also known as 17-(3-pyridyl)androsta-5,16-dien-3β-ol, is a synthetic, steroidal CYP17A1 inhibitor.
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Abiraterone acetate
Abiraterone acetate, sold under the brand name Zytiga among others, is an antiandrogen medication which is used in the treatment of prostate cancer.
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Active metabolite
An active metabolite is an active form of a drug after it has been processed by the body.
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Adjuvant therapy
Adjuvant therapy, also known as adjunct therapy, add-on therapy, and adjuvant care, is therapy that is given in addition to the primary or initial therapy to maximize its effectiveness.
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Androgen
An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.
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Dutasteride
Dutasteride, sold under the brand name Avodart among others, is a medication used primarily to treat enlarged prostate in men.
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Esterase
An esterase is a hydrolase enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis.
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Δ4-Abiraterone
Δ4-Abiraterone (D4A; code name CB-7627), also known as 17-(3-pyridyl)androsta-4,16-dien-3-one, is a steroidogenesis inhibitor and active metabolite of abiraterone acetate, a drug which is used in the treatment of prostate cancer and is itself a prodrug of abiraterone (another active metabolite of abiraterone acetate).
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Prostate cancer
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.
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3β-Hydroxysteroid dehydrogenase
3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.
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5α-Reductase
5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.
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5α-Reductase inhibitor
5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss.
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17-(3-Pyridyl)-5α-androst-16-en-3-one, 17-(3-pyridyl)-5α-androst-16-en-3-one, 3-keto-5α-abiraterone.
