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40 relations: Active metabolite, Analgesic, Anticonvulsant, Antiparkinson medication, Bioavailability, Calcium, Chemical synapse, Clinical trial, Dextromethorphan, Dextrorotation and levorotation, Dextrorphan, Dissociation (psychology), Dopaminergic, Food and Drug Administration, Glutamic acid, Hallucination, Levorphanol, Lipopolysaccharide, Methyl group, Morphinan, MPTP, Neuron, Neuroprotection, Neurotrophic factors, New Drug Application, Nigrostriatal pathway, NMDA receptor, Norlevorphanol, Opioid, Parkinson's disease, Potency (pharmacology), Prodrug, Protein kinase C, Psychoactive drug, Racemic mixture, Side effect, Stereoisomerism, Structural analog, United States, 3-Methoxymorphinan.
Active metabolite
An active metabolite is an active form of a drug after it has been processed by the body.
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Analgesic
An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
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Anticonvulsant
Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.
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Antiparkinson medication
An antiparkinson medication is a type of drug which is intended to treat and relieve the symptoms of Parkinson's disease.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Calcium
Calcium is a chemical element with symbol Ca and atomic number 20.
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Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Dextromethorphan
Dextromethorphan (DXM or DM) is a drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).
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Dextrorotation and levorotation
Dextrorotation and levorotation (also spelled as laevorotation)The first word component dextro- comes from Latin word for dexter "right (as opposed to left)".
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Dextrorphan
Dextrorphan (DXO) is a psychoactive drug of the morphinan class which acts as an antitussive or cough suppressant and dissociative hallucinogen.
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Dissociation (psychology)
In psychology, dissociation is any of a wide array of experiences from mild detachment from immediate surroundings to more severe detachment from physical and emotional experiences.
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Dopaminergic
Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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Hallucination
A hallucination is a perception in the absence of external stimulus that has qualities of real perception.
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Levorphanol
Levorphanol (INN; brand name Levo-Dromoran) is an opioid medication used to treat moderate to severe pain.
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Lipopolysaccharide
Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.
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Methyl group
A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.
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Morphinan
Morphinan is the prototype chemical structure of a large chemical class of psychoactive drugs, consisting of opiate analgesics, cough suppressants, and dissociative hallucinogens, among others.
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MPTP
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Neuroprotection
Neuroprotection refers to the relative preservation of neuronal structure and/or function.
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Neurotrophic factors
Neurotrophic factors (NTFs) are a family of biomolecules – nearly all of which are peptides or small proteins – that support the growth, survival, and differentiation of both developing and mature neurons.
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New Drug Application
The Food and Drug Administration's New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing.
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Nigrostriatal pathway
The nigrostriatal pathway or the nigrostriatal bundle (NSB), is a dopaminergic pathway that connects the substantia nigra pars compacta (SNc) with the dorsal striatum (i.e., the caudate nucleus and putamen).
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NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
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Norlevorphanol
Norlevorphanol is an opioid analgesic of the morphinan family that was never marketed.
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Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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Prodrug
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
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Protein kinase C
Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
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Psychoactive drug
A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior.
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Racemic mixture
In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.
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Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
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Stereoisomerism
In stereochemistry, stereoisomers are isomeric molecules that have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space.
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Structural analog
A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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3-Methoxymorphinan
3-Methoxymorphinan is a levomethorphan metabolite that has been shown to produce local anesthetic effects.
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Redirects here:
3-HO-Morphinan, 3-HO-morphinan, 3-OH-Morphinan, 3-OH-morphinan, 3-hydroxymorphinan, C16H21NO, Hydroxymorphinan, Morphinan-3-ol, Morphinanol, Normorphanol, Norracemorphanol, Racenormorphanol.
References
[1] https://en.wikipedia.org/wiki/3-Hydroxymorphinan
