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12 relations: Adenosine receptor, Anti-inflammatory, Cyclic adenosine monophosphate, IC50, Innate immune system, Leukotriene, PDE9, Phosphodiesterase inhibitor, Protein kinase A, TNF inhibitor, Xanthine, 3',5'-cyclic-AMP phosphodiesterase.
Adenosine receptor
The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ligand.
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Anti-inflammatory
Anti-inflammatory, or antiinflammatory, refers to the property of a substance or treatment that reduces inflammation or swelling.
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Cyclic adenosine monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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Innate immune system
The innate immune system, also known as the non-specific immune system or in-born immunity system, is an important subsystem of the overall immune system that comprises the cells and mechanisms involved in the defense of the host from infection by other organisms.
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Leukotriene
Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA) and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase.
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PDE9
Phosphodiesterase type 9 (PDE9) is a type of phosphodiesterase enzyme.
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Phosphodiesterase inhibitor
A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
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Protein kinase A
In cell biology, protein kinase A (PKANot to be confused with pKa, the symbol for the acid dissociation constant.) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP).
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TNF inhibitor
A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response.
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Xanthine
Xanthine (or; archaically xanthic acid) (3,7-dihydropurine-2,6-dione), is a purine base found in most human body tissues and fluids and in other organisms.
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3',5'-cyclic-AMP phosphodiesterase
3',5'-cyclic-AMP phosphodiesterase (cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3',5'-cyclic-AMP 5'-nucleotidohydrolase.
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3-isobutyl-1-methylxanthine, Isobutylmethylxanthine.
