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10 relations: Agonist, Baclofen, Binding selectivity, GABA analogue, GABAA receptor, GABAB receptor, IC50, Oral administration, Phenibut, Tolibut.
Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Baclofen
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat spasticity.
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Binding selectivity
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
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GABA analogue
A GABA analogue is a compound which is an analogue or derivative of the neurotransmitter gamma-Aminobutyric acid (GABA) (the IUPAC of which is 4-aminobutanoic acid).
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GABAA receptor
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
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GABAB receptor
GABAB receptors (GABABR) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels.
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IC50
The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.
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Oral administration
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Phenibut
Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic and sedative effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications.
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Tolibut
Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia.
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4-F-Phenibut, 4-F-phenibut, 4-fluorophenibut, Baflofen, C10H12FNO2, CGP 11,130, CGP 11130, CGP-11,130, CGP-11130, CGP11,130, CGP11130, Cgp 11,130, Cgp 11130, Cgp-11,130, Cgp-11130, Cgp11,130, Cgp11130, F-Phenibut, F-phenibut, Fluoribut, Fluorophenibut, Β-(4-Fluorophenyl)-GABA, Β-(4-fluorophenyl)-GABA, Β-(p-Fluorophenyl)-GABA, Β-(p-fluorophenyl)-GABA.
