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4-Hydroxyphenylacetate 3-monooxygenase

Index 4-Hydroxyphenylacetate 3-monooxygenase

4-hydroxyphenylacetate 3-monooxygenase is an enzyme that catalyzes the chemical reaction This reaction is the first step in a pathway found in enteric bacteria such as Escherichia coli and soil bacteria such as Pseudomonas putida which degrades 4-hydroxyphenylacetate (4-HPA), allowing these bacteria to use 4-HPA and other aromatic compounds found in mammalian digestive tracts or in soil as a carbon source. [1]

31 relations: Acinetobacter baumannii, Acyl CoA dehydrogenase, Alpha helix, Beta barrel, Carbon dioxide, Catabolism, Catalysis, Chemical reaction, Convergent evolution, Enzyme, Escherichia coli, Flavin adenine dinucleotide, Flavin mononucleotide, Hydrogen bond, Hydrogen peroxide, L-DOPA, Metabolic engineering, Nicotinamide adenine dinucleotide, Nicotinamide adenine dinucleotide phosphate, Oxygen, Phenylpropanoid, Pseudomonas putida, PyMOL, Pyruvic acid, Resveratrol, Succinic acid, Thermus thermophilus, Tyrosine, Water, 3,4-Dihydroxyphenylacetic acid, 4-Hydroxyphenylacetic acid.

Acinetobacter baumannii

Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium.

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Acyl CoA dehydrogenase

Acyl-CoA dehydrogenases (ACADs) are a class of enzymes that function to catalyze the initial step in each cycle of fatty acid β-oxidation in the mitochondria of cells.

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Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

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Beta barrel

A beta barrel is a beta-sheet that twists and coils to form a closed structure in which the first strand is hydrogen bonded to the last.

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Carbon dioxide

Carbon dioxide (chemical formula) is a colorless gas with a density about 60% higher than that of dry air.

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Catabolism

Catabolism (from Greek κάτω kato, "downward" and βάλλειν ballein, "to throw") is the set of metabolic pathways that breaks down molecules into smaller units that are either oxidized to release energy or used in other anabolic reactions.

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Catalysis

Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.

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Convergent evolution

Convergent evolution is the independent evolution of similar features in species of different lineages.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Escherichia coli

Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).

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Flavin adenine dinucleotide

In biochemistry, flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

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Flavin mononucleotide

Flavin mononucleotide (FMN), or riboflavin-5′-phosphate, is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors.

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Hydrogen bond

A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.

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Hydrogen peroxide

Hydrogen peroxide is a chemical compound with the formula.

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L-DOPA

L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.

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Metabolic engineering

Metabolic engineering is the practice of optimizing genetic and regulatory processes within cells to increase the cells' production of a certain substance.

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Nicotinamide adenine dinucleotide

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells.

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Nicotinamide adenine dinucleotide phosphate

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

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Oxygen

Oxygen is a chemical element with symbol O and atomic number 8.

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Phenylpropanoid

The phenylpropanoids are a diverse family of organic compounds that are synthesized by plants from the amino acids phenylalanine and tyrosine.

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Pseudomonas putida

Pseudomonas putida is a Gram-negative, rod-shaped, saprotrophic soil bacterium.

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PyMOL

PyMOL is computer software, a molecular visualization system created by Warren Lyford DeLano.

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Pyruvic acid

Pyruvic acid (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group.

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Resveratrol

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi.

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Succinic acid

Succinic acid is a dicarboxylic acid with the chemical formula (CH2)2(CO2H)2.

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Thermus thermophilus

Thermus thermophilus is a Gram negative eubacterium used in a range of biotechnological applications, including as a model organism for genetic manipulation, structural genomics, and systems biology.

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Tyrosine

Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.

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Water

Water is a transparent, tasteless, odorless, and nearly colorless chemical substance that is the main constituent of Earth's streams, lakes, and oceans, and the fluids of most living organisms.

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3,4-Dihydroxyphenylacetic acid

3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine.

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4-Hydroxyphenylacetic acid

4-Hydroxyphenylacetic acid is a chemical compound found in olive oil and beer.

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Redirects here:

4-hydroxyphenylacetate 3-monooxygenase, 4-hydroxyphenylacetate,FAD:oxygen oxidoreductase (3-hydroxylating), 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase, 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating), EC 1.14.13.3, EC 1.14.14.9.

References

[1] https://en.wikipedia.org/wiki/4-Hydroxyphenylacetate_3-monooxygenase

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