4-Methoxyestradiol

4-Methoxyestradiol (4-ME2) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estradiol that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestradiol. ^[1]

Catechol estrogen

A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. 4-Methoxyestradiol and catechol estrogen are Estranes, estrogens, Human metabolites and steroid hormones.

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Catechol-O-methyltransferase

Catechol-O-methyltransferase (COMT) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

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Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. 4-Methoxyestradiol and Estradiol are Estranes, estrogens and secondary alcohols.

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Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. 4-Methoxyestradiol and Estrogen are Estranes and estrogens.

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Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. 4-Methoxyestradiol and Estrone are Estranes and estrogens.

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Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

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Methoxy group

In organic chemistry, a methoxy group is the functional group consisting of a methyl group bound to oxygen.

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Natural product

A natural product is a natural compound or substance produced by a living organism—that is, found in nature.

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Reaction intermediate

In chemistry, a reaction intermediate, or intermediate, is a molecular entity arising within the sequence of a stepwise chemical reaction.

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2-Methoxyestradiol

2-Methoxyestradiol (2-ME2, 2-MeO-E2) is a natural metabolite of estradiol and 2-hydroxyestradiol (2-OHE2). 4-Methoxyestradiol and 2-Methoxyestradiol are Estranes, Ethers and Human metabolites.

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2-Methoxyestriol

2-Methoxyestriol (2-MeO-E3) is an endogenous estrogen metabolite. 4-Methoxyestradiol and 2-Methoxyestriol are Estranes, Ethers, Human metabolites and steroid stubs.

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2-Methoxyestrone

2-Methoxyestrone (2-ME1) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 2-hydroxyestrone. 4-Methoxyestradiol and 2-Methoxyestrone are Estranes, Ethers, Human metabolites and steroid stubs.

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4-Hydroxyestradiol

4-Hydroxyestradiol (4-OHE2), also known as estra-1,3,5(10)-triene-3,4,17β-triol, is an endogenous, naturally occurring catechol estrogen and a minor metabolite of estradiol. 4-Methoxyestradiol and 4-Hydroxyestradiol are Estranes, estrogens, Human metabolites and steroid stubs.

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4-Hydroxyestrone

4-Hydroxyestrone (4-OHE1), also known as estra-1,3,5(10)-triene-3,4-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a minor metabolite of estrone and estradiol. 4-Methoxyestradiol and 4-Hydroxyestrone are Estranes, estrogens, Human metabolites and steroid stubs.

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4-Methoxyestrone

4-Methoxyestrone (4-ME1) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestrone. 4-Methoxyestradiol and 4-Methoxyestrone are Estranes, estrogens, Ethers, Human metabolites, steroid hormones and steroid stubs.

See 4-Methoxyestradiol and 4-Methoxyestrone

References

[1] https://en.wikipedia.org/wiki/4-Methoxyestradiol

Also known as 4-ME2, 4-MeO-E2, 4-MeOE2.

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