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4-aminobutyrate transaminase

Index 4-aminobutyrate transaminase

In enzymology, 4-aminobutyrate transaminase, also called GABA transaminase or 4-aminobutyrate aminotransferase, is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are 4-aminobutanoate (GABA) and 2-oxoglutarate. [1]

27 relations: Alpha-Ketoglutaric acid, Aminooxyacetic acid, Biomolecular structure, Butyric acid, Catalysis, Chemical reaction, Cofactor (biochemistry), Enzyme, Gabaculine, Gamma-Aminobutyric acid, Glutamic acid, Β-Alanine, List of enzymes, Metabolism, Phenelzine, Phenylethylidenehydrazine, Product (chemistry), Propionic acid, Protein Data Bank, Pyridoxal phosphate, Rosmarinic acid, Substrate (chemistry), Succinic semialdehyde, Transaminase, Transferase, Valproate, Vigabatrin.

Alpha-Ketoglutaric acid

α-Ketoglutaric acid (2-oxoglutaric acid) is one of two ketone derivatives of glutaric acid.

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Aminooxyacetic acid

Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading to less gamma-aminobutyric acid (GABA) being broken down.

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Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.

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Butyric acid

Butyric acid (from βούτῡρον, meaning "butter"), also known under the systematic name butanoic acid, abbreviated BTA, is a carboxylic acid with the structural formula CH3CH2CH2-COOH.

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Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.

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Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.

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Enzymes are macromolecular biological catalysts.

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Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor.

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Gamma-Aminobutyric acid

gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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β-Alanine (or beta-alanine) is a naturally occurring beta amino acid, which is an amino acid in which the amino group is at the β-position from the carboxylate group (i.e., two atoms away, see Figure 1).

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List of enzymes

This page lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission numbering system.

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Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Phenelzine (Nardil, Nardelzine) is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class which is used as an antidepressant and anxiolytic.

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Phenylethylidenehydrazine (PEH), also known as 2-phenylethylhydrazone or β-phenylethylidenehydrazine, is an inhibitor of the enzyme GABA transaminase (GABA-T).

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Product (chemistry)

Products are the species formed from chemical reactions.

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Propionic acid

Propionic acid (from the Greek words protos, meaning "first", and pion, meaning "fat"; also known as propanoic acid) is a naturally occurring carboxylic acid with chemical formula C2H5COOH.

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Protein Data Bank

The Protein Data Bank (PDB) is a crystallographic database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids.

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Pyridoxal phosphate

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions.

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Rosmarinic acid

Rosmarinic acid is a chemical compound found in a variety of plants.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

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Succinic semialdehyde

Succinic semialdehyde (SSA) is a GABA metabolite.

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Transaminases or aminotransferases are enzymes that catalyze a transamination reaction between an amino acid and an α-keto acid.

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A transferase is any one of a class of enzymes that enact the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor).

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Valproate (VPA), and its valproic acid, sodium valproate, and valproate semisodium forms, are medications primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches.

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Vigabatrin, brand name Sabril, is an antiepileptic drug that inhibits the breakdown of γ-aminobutyric acid (GABA) by acting as a suicide inhibitor of the enzyme GABA transaminase (GABA-T).

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Redirects here:

4-Aminobutyrate aminotransferase, 4-aminobutanoate:2-oxoglutarate aminotransferase, EC, GABA-T, GABA-transaminase, Γ-Aminobutyrate aminotransferase, Γ-aminobutyrate aminotransferase.


[1] https://en.wikipedia.org/wiki/4-aminobutyrate_transaminase

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