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Aminopterin

Index Aminopterin

Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. [1]

69 relations: ABC News, Abortifacient, Abortion, Activated carbon, American Society for the Prevention of Cruelty to Animals, Anorexia (symptom), Birth defect, Bloomberg Businessweek, Cathartic, Cell culture, Chemotherapy, Chills, CNN, Cornell University, Cure, Dana–Farber Cancer Institute, Dihydrofolate reductase, DNA, Emergency Planning and Community Right-to-Know Act, Enzyme, Enzyme inhibitor, Erythema, Fever, Folate, Folinic acid, Food and Drug Administration, Gastrointestinal bleeding, HAT medium, Hybridoma technology, Hyperpigmentation, Immunosuppression, Kidney failure, Lethal dose, Leukemia, List of extremely hazardous substances, Melamine, Menu Foods, Methotrexate, Monoclonal antibody, National Oceanic and Atmospheric Administration, Nausea, New York (state), Nucleotide, Ontario, Oral mucosa, Parts-per notation, Pharyngitis, Pharynx, Pigment, Pregnancy, ..., Protein biosynthesis, Pterin, Redox, RNA, Rodenticide, Sidney Farber, Sorbitol, Stomatitis, Teratology, Tetrahydrofolic acid, Therapeutic index, United States Environmental Protection Agency, United States Government Publishing Office, United States National Library of Medicine, University of Guelph, Vomiting, Weight loss, Yellapragada Subbarow, 2007 pet food recalls. Expand index (19 more) »

ABC News

ABC News is the news division of the American Broadcasting Company (ABC), owned by the Disney Media Networks division of The Walt Disney Company.

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Abortifacient

An abortifacient ("that which will cause a miscarriage" from Latin: abortus "miscarriage" and faciens "making") is a substance that induces abortion.

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Abortion

Abortion is the ending of pregnancy by removing an embryo or fetus before it can survive outside the uterus.

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Activated carbon

Activated carbon, also called activated charcoal, is a form of carbon processed to have small, low-volume pores that increase the surface area available for adsorption or chemical reactions.

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American Society for the Prevention of Cruelty to Animals

The American Society for the Prevention of Cruelty to Animals (ASPCA) is a non-profit organization dedicated to preventing cruelty to animals.

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Anorexia (symptom)

Anorexia (from Ancient Greek ανορεξία: 'ἀν-' "without" + 'όρεξις', spelled 'órexis' meaning "appetite") is the decreased sensation of appetite.

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Birth defect

A birth defect, also known as a congenital disorder, is a condition present at birth regardless of its cause.

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Bloomberg Businessweek

Bloomberg Businessweek is an American weekly business magazine published by Bloomberg L.P. Businessweek was founded in 1929.

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Cathartic

In medicine, a cathartic is a substance that accelerates defecation.

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Cell culture

Cell culture is the process by which cells are grown under controlled conditions, generally outside their natural environment.

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Chills

Chills is a feeling of coldness occurring during a high fever, but sometimes is also a common symptom which occurs alone in specific people.

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CNN

Cable News Network (CNN) is an American basic cable and satellite television news channel and an independent subsidiary of AT&T's WarnerMedia.

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Cornell University

Cornell University is a private and statutory Ivy League research university located in Ithaca, New York.

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Cure

A cure is a substance or procedure that ends a medical condition, such as a medication, a surgical operation, a change in lifestyle or even a philosophical mindset that helps end a person's sufferings; or the state of being healed, or cured.

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Dana–Farber Cancer Institute

Dana–Farber Cancer Institute is a comprehensive cancer treatment and research center in Boston, Massachusetts.

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Dihydrofolate reductase

Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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Emergency Planning and Community Right-to-Know Act

The Emergency Planning and Community Right-to-Know Act of 1986 is a United States federal law passed by the 99th United States Congress located at Title 42, Chapter 116 of the U.S. Code, concerned with emergency response preparedness.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Enzyme inhibitor

4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

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Erythema

Erythema (from the Greek erythros, meaning red) is redness of the skin or mucous membranes, caused by hyperemia (increased blood flow) in superficial capillaries.

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Fever

Fever, also known as pyrexia and febrile response, is defined as having a temperature above the normal range due to an increase in the body's temperature set-point.

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Folate

Folate, distinct forms of which are known as folic acid, folacin, and vitamin B9, is one of the B vitamins.

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Folinic acid

Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Gastrointestinal bleeding

Gastrointestinal bleeding (GI bleed), also known as gastrointestinal hemorrhage, is all forms of bleeding in the gastrointestinal tract, from the mouth to the rectum.

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HAT medium

HAT Medium (hypoxanthine-aminopterin-thymidine medium) is a selection medium for mammalian cell culture, which relies on the combination of aminopterin, a drug that acts as a powerful folate metabolism inhibitor by inhibiting dihydrofolate reductase, with hypoxanthine (a purine derivative) and thymidine (a deoxynucleoside) which are intermediates in DNA synthesis.

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Hybridoma technology

Hybridoma technology is a method for producing large numbers of identical antibodies (also called monoclonal antibodies).

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Hyperpigmentation

Hyperpigmentation is the darkening of an area of skin or nails caused by increased melanin.

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Immunosuppression

Immunosuppression is a reduction of the activation or efficacy of the immune system.

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Kidney failure

Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys no longer work.

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Lethal dose

In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation.

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Leukemia

Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.

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List of extremely hazardous substances

This is the list of extremely hazardous substances defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002).

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Melamine

Melamine is the organic compound with the formula C3H6N6.

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Menu Foods

Menu Foods Limited, based in Streetsville in Mississauga, Ontario, Canada, was the largest maker of wet cat and dog food in North America, with its products sold under 95 brand names, which the company identifies as supermarkets, big box and pet product retailers and wholesalers.

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Methotrexate

Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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National Oceanic and Atmospheric Administration

The National Oceanic and Atmospheric Administration (NOAA; pronounced, like "Noah") is an American scientific agency within the United States Department of Commerce that focuses on the conditions of the oceans, major waterways, and the atmosphere.

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Nausea

Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.

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New York (state)

New York is a state in the northeastern United States.

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Nucleotide

Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.

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Ontario

Ontario is one of the 13 provinces and territories of Canada and is located in east-central Canada.

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Oral mucosa

The oral mucosa is the mucous membrane lining the inside of the mouth and consists of stratified squamous epithelium termed oral epithelium and an underlying connective tissue termed lamina propria.

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Parts-per notation

In science and engineering, the parts-per notation is a set of pseudo-units to describe small values of miscellaneous dimensionless quantities, e.g. mole fraction or mass fraction.

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Pharyngitis

Pharyngitis is inflammation of the back of the throat, known as the pharynx.

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Pharynx

The pharynx (plural: pharynges) is the part of the throat that is behind the mouth and nasal cavity and above the esophagus and the larynx, or the tubes going down to the stomach and the lungs.

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Pigment

A pigment is a material that changes the color of reflected or transmitted light as the result of wavelength-selective absorption.

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Pregnancy

Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.

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Protein biosynthesis

Protein synthesis is the process whereby biological cells generate new proteins; it is balanced by the loss of cellular proteins via degradation or export.

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Pterin

Pterin is a heterocyclic compound composed of a pteridine ring system, with a keto group and an amino group on positions 4 and 2 respectively.

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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RNA

Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.

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Rodenticide

Rodenticides, colloquially rat poison, are typically non-specific pest control chemicals made and sold for the purpose of killing rodents.

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Sidney Farber

Sidney Farber (September 30, 1903 – March 30, 1973) was an American pediatric pathologist.

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Sorbitol

Sorbitol, less commonly known as glucitol, is a sugar alcohol with a sweet taste which the human body metabolizes slowly.

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Stomatitis

Stomatitis is inflammation of the mouth and lips.

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Teratology

Teratology is the study of abnormalities of physiological development.

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Tetrahydrofolic acid

Tetrahydrofolic acid, or tetrahydrofolate, is a folic acid derivative.

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Therapeutic index

The therapeutic index (TI; also referred to as therapeutic ratio) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity.

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United States Environmental Protection Agency

The Environmental Protection Agency is an independent agency of the United States federal government for environmental protection.

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United States Government Publishing Office

The United States Government Publishing Office (GPO) (formerly the Government Printing Office) is an agency of the legislative branch of the United States federal government.

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United States National Library of Medicine

The United States National Library of Medicine (NLM), operated by the United States federal government, is the world's largest medical library.

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University of Guelph

The University of Guelph (U of G) is a comprehensive public research university in Guelph, Ontario, Canada.

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Vomiting

Vomiting, also known as emesis, puking, barfing, throwing up, among other terms, is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.

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Weight loss

Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose tissue or lean mass, namely bone mineral deposits, muscle, tendon, and other connective tissue.

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Yellapragada Subbarow

Yellapragada Subbarao (12 January 1895 – 8 August 1948) was an Indian biochemist who discovered the function of adenosine triphosphate as an energy source in the cell, developed methotrexate for the treatment of cancer and discovered a broad spectrum antibiotic Auromycin and Tetracycline.

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2007 pet food recalls

The 2007 pet food recalls comprise the contamination and wide recall of many brands of cat and dog foods beginning in March 2007, and the ensuing developments involving the human food supply.

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Redirects here:

4-aminofolic acid, 4-aminopteroylglutamic acid, Aminopteria, Aminopterin sodium, Aminopteroylglutamic acid, Animopterin, C19H20N8O5.

References

[1] https://en.wikipedia.org/wiki/Aminopterin

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