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5'-Guanidinonaltrindole

Index 5'-Guanidinonaltrindole

5'-Guanidinonaltrindole (5'-GNTI) is an opioid antagonist used in scientific research which is highly selective for the κ opioid receptor. [1]

15 relations: Allodynia, Allosteric modulator, Alpha-1A adrenergic receptor, Antidepressant, Binaltorphimine, British Journal of Pharmacology, Dynorphin, EC50, Κ-opioid receptor, JDTic, Norbinaltorphimine, Opioid, Receptor (biochemistry), Receptor antagonist, 6'-Guanidinonaltrindole.

Allodynia

Allodynia (Ancient Greek άλλος állos "other" and οδύνη odúnē "pain") refers to central pain sensitization (increased response of neurons) following normally non-painful, often repetitive, stimulation.

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Allosteric modulator

In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.

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Alpha-1A adrenergic receptor

The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

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Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Binaltorphimine

Binaltorphimine (BNI) is a selective antagonist of the κ-opioid receptor (KOR).

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British Journal of Pharmacology

The British Journal of Pharmacology is a biweekly peer-reviewed medical journal covering all aspects of experimental pharmacology.

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Dynorphin

Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin.

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EC50

Half maximal effective concentration (EC50) refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.

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Κ-opioid receptor

The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.

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JDTic

JDTic is a selective, long-acting ("inactivating") antagonist of the κ-opioid receptor (KOR).

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Norbinaltorphimine

Norbinaltorphimine (nor-BNI or nBNI) is an opioid antagonist used in scientific research.

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Opioid

Opioids are substances that act on opioid receptors to produce morphine-like effects.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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6'-Guanidinonaltrindole

6'-Guanidinonaltrindole (6'-GNTI) is a κ−δ-opioid receptor selective ligand used in scientific research.

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References

[1] https://en.wikipedia.org/wiki/5'-Guanidinonaltrindole

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