15 relations: Allodynia, Allosteric modulator, Alpha-1A adrenergic receptor, Antidepressant, Binaltorphimine, British Journal of Pharmacology, Dynorphin, EC50, Κ-opioid receptor, JDTic, Norbinaltorphimine, Opioid, Receptor (biochemistry), Receptor antagonist, 6'-Guanidinonaltrindole.
Allodynia
Allodynia (Ancient Greek άλλος állos "other" and οδύνη odúnē "pain") refers to central pain sensitization (increased response of neurons) following normally non-painful, often repetitive, stimulation.
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Allosteric modulator
In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.
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Alpha-1A adrenergic receptor
The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
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Antidepressant
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
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Binaltorphimine
Binaltorphimine (BNI) is a selective antagonist of the κ-opioid receptor (KOR).
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British Journal of Pharmacology
The British Journal of Pharmacology is a biweekly peer-reviewed medical journal covering all aspects of experimental pharmacology.
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Dynorphin
Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin.
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EC50
Half maximal effective concentration (EC50) refers to the concentration of a drug, antibody or toxicant which induces a response halfway between the baseline and maximum after a specified exposure time.
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Κ-opioid receptor
The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.
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JDTic
JDTic is a selective, long-acting ("inactivating") antagonist of the κ-opioid receptor (KOR).
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Norbinaltorphimine
Norbinaltorphimine (nor-BNI or nBNI) is an opioid antagonist used in scientific research.
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Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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6'-Guanidinonaltrindole
6'-Guanidinonaltrindole (6'-GNTI) is a κ−δ-opioid receptor selective ligand used in scientific research.
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