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5-HT1B receptor

Index 5-HT1B receptor

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene. [1]

42 relations: Antidepressant, Antipsychotic, Aphrodisiac, AR-A000002, Aripiprazole, Asenapine, Autoreceptor, Basal ganglia, CGS-12066A, Cough medicine, CP-122,288, CP-94253, Dextromethorphan, Dopamine, Ergotamine, Excitatory postsynaptic potential, Frontal lobe, Gene, Heteroreceptor, Hippocampus, Isamoltane, Knockout mouse, Metergoline, Metitepine, Osteoblast, Oxymetazoline, Protein, SB-216641, SB-236057, Selective serotonin reuptake inhibitor, Serotonin, Striatum, Sumatriptan, Trait theory, Vasoconstriction, Vortioxetine, Yohimbine, Ziprasidone, Zolmitriptan, 5-Carboxamidotryptamine, 5-HT receptor, 5-HT1 receptor.

Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Antipsychotic

Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.

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Aphrodisiac

An aphrodisiac or love drug is a substance that increases libido when consumed.

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AR-A000002

AR-A000002 is a drug which is one of the first compounds developed to act as a selective antagonist for the serotonin receptor 5-HT1B, with approximately 10x selectivity for 5-HT1B over the closely related 5-HT1D receptor.

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Aripiprazole

Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. According to a Cochrane review, evidence for the oral form in schizophrenia is not sufficient to determine effects on general functioning. Additionally, because many people dropped out of the medication trials before they were completed, the overall strength of the conclusions is low. Side effects include neuroleptic malignant syndrome, a movement disorder known as tardive dyskinesia, and high blood sugar in those with diabetes. In the elderly there is an increased risk of death. It is thus not recommended for use in those with psychosis due to dementia. It is pregnancy category C in the United States and category C in Australia, meaning there is possible evidence of harm to the fetus. It is not recommended for women who are breastfeeding. It is unclear whether it is safe or effective in people less than 18 years old. It is a partial dopamine agonist. Aripiprazole was developed by Otsuka in Japan. In the United States, Otsuka America markets it jointly with Bristol-Myers Squibb. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.

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Asenapine

Asenapine, sold under the trade names Saphris and Sycrest among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder.

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Autoreceptor

An autoreceptor is a type of receptor located in the membranes of presynaptic nerve cells.

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Basal ganglia

The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.

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CGS-12066A

CGS-12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT2 receptor subtypes.

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Cough medicine

Cough medicines are medications used in those with coughing and related conditions.

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CP-122,288

CP-122,288 is a drug which acts as a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes.

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CP-94253

CP-94253 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors.

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Dextromethorphan

Dextromethorphan (DXM or DM) is a drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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Ergotamine

Ergotamine is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline.

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Excitatory postsynaptic potential

In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential.

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Frontal lobe

The frontal lobe, located at the front of the brain, is the largest of the four major lobes of the cerebral cortex in the mammalian brain.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Heteroreceptor

A heteroreceptor is a receptor regulating the synthesis and/or the release of mediators other than its own ligand.

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Hippocampus

The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.

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Isamoltane

Isamoltane (CGP-361A) is a drug used in scientific research.

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Knockout mouse

A knockout mouse or knock-out mouse is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA.

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Metergoline

Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.

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Metitepine

Metitepine (developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic group which was never marketed.

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Osteoblast

Osteoblasts (from the Greek combining forms for "bone", ὀστέο-, osteo- and βλαστάνω, blastanō "germinate") are cells with a single nucleus that synthesize bone.

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Oxymetazoline

Oxymetazoline is a selective α1 adrenergic receptor agonist and α2 adrenergic receptor partial agonist.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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SB-216641

SB-216641 is a drug which is a selective antagonist for the serotonin receptor 5-HT1B, with around 25x selectivity over the closely related 5-HT1D receptor.

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SB-236057

SB-236057 is a compound which is a potent and selective inverse agonist for the serotonin receptor 5-HT1B, acting especially at 5-HT1B autoreceptors on nerve terminals.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Striatum

The striatum, or corpus striatum (also called the neostriatum and the striate nucleus) is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain.

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Sumatriptan

Sumatriptan is a medication used for the treatment of migraine and cluster headaches.

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Trait theory

In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.

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Vasoconstriction

Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles.

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Vortioxetine

Vortioxetine is an antidepressant medication that is prescribed to treat depression.

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Yohimbine

Yohimbine is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree in Central Africa.

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Ziprasidone

Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic which is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder.

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Zolmitriptan

Zolmitriptan is a selective serotonin receptor agonist of the 1B and 1D subtypes.

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5-Carboxamidotryptamine

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.

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5-HT receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.

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5-HT1 receptor

The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT).

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Redirects here:

5-HT1B, 5HT1B receptor, HTR1B, HTR1B (gene).

References

[1] https://en.wikipedia.org/wiki/5-HT1B_receptor

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