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5-HT1B receptor

Index 5-HT1B receptor

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene. [1]

Table of Contents

  1. 47 relations: Antidepressant, Antipsychotic, Aphrodisiac, AR-A000002, Aripiprazole, Asenapine, Autoreceptor, Basal ganglia, Central nervous system, CGS-12066A, Cold medicine, CP-122,288, CP-94253, Dextromethorphan, Dopamine, Elevated plus maze, Endothelium, Ergotamine, Excitatory postsynaptic potential, Frontal lobe, Gene, Heteroreceptor, Hippocampus, Isamoltane, Knockout mouse, Meninges, Metergoline, Metitepine, Osteoblast, Oxymetazoline, Protein, SB-216641, SB-236057, Selective serotonin reuptake inhibitor, Serotonin, Striatum, Sumatriptan, Trait theory, Vasoconstriction, Vortioxetine, Yohimbine, Ziprasidone, Zolmitriptan, 5-Carboxamidotryptamine, 5-HT receptor, 5-HT1 receptor, 5-HT1D receptor.

  2. Biology of attention deficit hyperactivity disorder
  3. Serotonin receptors

Antidepressant

Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction.

See 5-HT1B receptor and Antidepressant

Antipsychotic

Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders.

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Aphrodisiac

An aphrodisiac is a substance alleged to increase libido, sexual desire, sexual attraction, sexual pleasure, or sexual behavior.

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AR-A000002

AR-A000002 is a drug which is one of the first compounds developed to act as a selective antagonist for the serotonin receptor 5-HT1B, with approximately 10x selectivity for 5-HT1B over the closely related 5-HT1D receptor.

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Aripiprazole

Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder; other uses include as an add-on treatment in major depressive disorder and obsessive compulsive disorder (OCD), tic disorders, and irritability associated with autism.

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Asenapine

Asenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder.

See 5-HT1B receptor and Asenapine

Autoreceptor

An autoreceptor is a type of receptor located in the membranes of nerve cells.

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Basal ganglia

The basal ganglia (BG) or basal nuclei are a group of subcortical nuclei found in the brains of vertebrates.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.

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CGS-12066A

CGS-12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT2 receptor subtypes.

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Cold medicine

Cold medicines are a group of medications taken individually or in combination as a treatment for the symptoms of the common cold and similar conditions of the upper respiratory tract.

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CP-122,288

CP-122,288 is a drug which acts as a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes.

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CP-94253

CP-94253 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 25× and 40× selectivity over the closely related 5-HT1D and 5-HT1A receptors.

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Dextromethorphan

Dextromethorphan (DXM), sold under the trade name Robitussin among others, is a cough suppressant used in many cough and cold medicines.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. 5-HT1B receptor and Dopamine are biology of attention deficit hyperactivity disorder.

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Elevated plus maze

The elevated plus maze (EPM) is a test measuring anxiety in laboratory animals that usually uses rodents as a screening test for putative anxiolytic or anxiogenic compounds and as a general research tool in neurobiological anxiety research such as PTSD and TBI.

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Endothelium

The endothelium (endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels.

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Ergotamine

Ergotamine, sold under the brand name Ergomar among others, is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline.

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Excitatory postsynaptic potential

In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential.

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Frontal lobe

The frontal lobe is the largest of the four major lobes of the brain in mammals, and is located at the front of each cerebral hemisphere (in front of the parietal lobe and the temporal lobe).

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Gene

In biology, the word gene has two meanings.

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Heteroreceptor

A heteroreceptor is a receptor regulating the synthesis and/or the release of mediators other than its own ligand.

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Hippocampus

The hippocampus (hippocampi; via Latin from Greek ἱππόκαμπος, 'seahorse') is a major component of the brain of humans and other vertebrates.

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Isamoltane

Isamoltane (CGP-361A) is a drug used in scientific research.

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Knockout mouse

A knockout mouse, or knock-out mouse, is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA.

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Meninges

In anatomy, the meninges (meninx) are the three membranes that envelop the brain and spinal cord.

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Metergoline

Metergoline, also known as methergoline and sold under the brand names Contralac (veterinary) and Liserdol (clinical), is a monoaminergic medication of the ergoline group which is used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) and to suppress lactation.

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Metitepine

Metitepine (developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic group which was never marketed.

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Osteoblast

Osteoblasts (from the Greek combining forms for "bone", ὀστέο-, osteo- and βλαστάνω, blastanō "germinate") are cells with a single nucleus that synthesize bone.

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Oxymetazoline

Oxymetazoline, sold under the brand name Afrin among others, is a topical decongestant and vasoconstrictor medication.

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Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.

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SB-216641

SB-216641 is a drug which is a selective antagonist for the serotonin receptor 5-HT1B, with around 25x selectivity over the closely related 5-HT1D receptor.

See 5-HT1B receptor and SB-216641

SB-236057

SB-236057 is a compound which is a potent and selective inverse agonist for the serotonin receptor 5-HT1B, acting especially at 5-HT1B autoreceptors on nerve terminals.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Striatum

The striatum (striata) or corpus striatum is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia.

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Sumatriptan

Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches.

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Trait theory

In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality.

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Vasoconstriction

Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles.

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Vortioxetine

Vortioxetine, sold under the brand name Brintellix among others, is an antidepressant of the serotonin modulator and stimulator (SMS) class.

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Yohimbine

Yohimbine, also known as quebrachine, is an indole alkaloid derived from the bark of the African tree Pausinystalia johimbe; also from the bark of the unrelated South American tree Aspidosperma quebracho-blanco.

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Ziprasidone

Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.

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Zolmitriptan

Zolmitriptan, sold under the brand name Zomig among others, is a triptan used in the acute treatment of migraine attacks with or without aura and cluster headaches.

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5-Carboxamidotryptamine

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.

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5-HT receptor

5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. 5-HT1B receptor and 5-HT receptor are serotonin receptors.

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5-HT1 receptor

The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). 5-HT1B receptor and 5-HT1 receptor are serotonin receptors.

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5-HT1D receptor

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it. 5-HT1B receptor and 5-HT1D receptor are serotonin receptors.

See 5-HT1B receptor and 5-HT1D receptor

See also

Biology of attention deficit hyperactivity disorder

Serotonin receptors

References

[1] https://en.wikipedia.org/wiki/5-HT1B_receptor

Also known as 5-HT1B, 5HT1B receptor, HTR1B, HTR1B (gene).