175 relations: Adenosine A1 receptor, Adrenocorticotropic hormone, Ageing, Agonist, AL-34662, Altanserin, AMPA receptor, Anti-inflammatory, Antipsychotic, Apical dendrite, Arachidonic acid, Arena Pharmaceuticals, Arrestin, Arrestin beta 2, Asenapine, Astrocyte, Atypical antipsychotic, B cell, Bipolar disorder, Blood–brain barrier, Bromo-DragonFLY, Bronchus, Calcium in biology, Caudate nucleus, Central nervous system, Cerebral cortex, Chromosome 13, Chronic fatigue syndrome, Circulatory system, Citalopram, Clathrin, Clozapine, Corticosterone, Cyproheptadine, Diglyceride, DMBMPP, Dopamine agonist, Dopamine receptor D2, Efavirenz, Effector (biology), Endocytosis, Eplivanserin, Ergoline, Ergot, Extracellular signal–regulated kinases, Fibroblast, Fluorine-18, Functional selectivity, G protein–coupled receptor, GABAA receptor, ..., Gastrointestinal tract, Glaucoma, Glutamic acid, Golgi cell, GPCR oligomer, Head-twitch response, Hippocampus, Hydroxyzine, Hypocretin (orexin) receptor 2, Inflammation, Inositol trisphosphate, Internal granular layer (cerebral cortex), International Immunology, Intron, Inverse agonist, Isotopic labeling, JC virus, Ketanserin, Ligand (biochemistry), Lipophilicity, Lisuride, LY-367,265, Lysergic acid diethylamide, Major depressive disorder, Mefloquine, Mescaline, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 5, Metergoline, Methylergometrine, Methysergide, Migraine, Mirtazapine, Monocyte, Monomer, Mood disorder, Morphine, Mouse, N,N-Dimethyltryptamine, Nefazodone, Nelotanserin, Neocortex, Neuroticism, Niaprazine, O-4310, Obsessive–compulsive disorder, Odds ratio, Olanzapine, Olfactory tubercle, Oligodendrocyte, OSU-6162, Oxytocin, Parietal lobe, PHA-57378, Phenethylamine, Phenoxybenzamine, Phospholipase A2, Phospholipase C, Phospholipase D, Pimavanserin, Pizotifen, Platelet, Polymorphism (biology), Polyomaviridae, Positron emission tomography, Prefrontal cortex, Primary somatosensory cortex, Progressive multifocal leukoencephalopathy, Prolactin, Protein kinase C, Psilocin, Psychedelic drug, Purkinje cell, Pyramidal cell, Quetiapine, Radioligand, Receptor (biochemistry), Renin, Revised NEO Personality Inventory, Rho family of GTPases, Rho-associated protein kinase, Risperidone, Ritanserin, Rs6311, Rs6313, Rs6314, Rs7997012, Sanofi, Schizophrenia, Schizophrenia Research Forum, Second messenger system, Selective serotonin reuptake inhibitor, Serotonin, Sialic acid, Signal transduction, Single-nucleotide polymorphism, Spiperone, Structure–activity relationship, Suicide, TCB-2, Tourette syndrome, Trazodone, Tryptamine, Tumor necrosis factor alpha, Vasoconstriction, Vasodilation, Visual cortex, Volinanserin, 2,5-Dimethoxy-4-iodoamphetamine, 25B-NBOMe, 25C-NBOMe, 25CN-NBOH, 25I-NBOH, 25I-NBOMe, 2C-N, 5-HT receptor, 5-HT1 receptor, 5-HT1A receptor, 5-HT2 receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT3 receptor, 5-MeO-NBpBrT, 5-Methoxytryptamine, 9-Aminomethyl-9,10-dihydroanthracene. Expand index (125 more) » « Shrink index
The adenosine A1 receptor is one member of the adenosine receptor group of G protein-coupled receptors with adenosine as endogenous ligand.
Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.
Ageing or aging (see spelling differences) is the process of becoming older.
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma.
Altanserin is a compound that binds to the 5-HT2A receptor (5-Hydroxytryptamine (serotonin) 2A receptor).
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS).
Anti-inflammatory, or antiinflammatory, refers to the property of a substance or treatment that reduces inflammation or swelling.
Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.
An apical dendrite is a dendrite that emerges from the apex of a pyramidal cell.
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).
Arena Pharmaceuticals, Inc. is a biopharmaceutical company founded in 1997 and located in San Diego, California.
Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors.
Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene.
Asenapine, sold under the trade names Saphris and Sycrest among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder.
Astrocytes (Astro from Greek astron.
The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
Bromo-DragonFLY (or 3C-Bromo-Dragonfly, DOB-Dragonfly) is a psychedelic drug related to the phenethylamine family.
A bronchus, is a passage of airway in the respiratory system that conducts air into the lungs.
Calcium ions (Ca2+) play a vital role in the physiology and biochemistry of organisms and the cell.
The caudate nucleus is one of the structures that make up the dorsal striatum, which is a component of the basal ganglia.
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.
Chromosome 13 is one of the 23 pairs of chromosomes in humans.
Chronic fatigue syndrome (CFS), also referred to as myalgic encephalomyelitis (ME), is a medical condition characterized by long-term fatigue and other symptoms that limit a person's ability to carry out ordinary daily activities.
The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.
Citalopram (brand names: Celexa, Cipramil and others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
Clathrin is a protein that plays a major role in the formation of coated vesicles.
Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.
Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages.
DMBMPP, or 2-(2,5-dimethoxy-4-bromobenzyl)-6-(2-methoxyphenyl)piperidine, is a 2-benzylpiperidine analog of the hallucinogenic N-benzylphenethylamine 25B-NBOMe and was discovered in 2011 by Jose Juncosa in the group of David E. Nichols at Purdue University.
A dopamine receptor agonist is a compound that activates dopamine receptors.
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
Efavirenz (EFV), sold under the brand names Sustiva among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.
In biochemistry, an effector molecule is usually a small molecule that selectively binds to a protein and regulates its biological activity.
Endocytosis is a form of bulk transport in which a cell transports molecules (such as proteins) into the cell (endo- + cytosis) by engulfing them in an energy-using process.
Eplivanserin (SR-46,349; planned trade name Ciltyri) was an experimental drug for the treatment of insomnia which was being developed by Sanofi Aventis.
Ergoline derivatives comprise a diverse group of chemical compounds whose structural skeleton is the alkaloid ergoline.
Ergot (pron.) or ergot fungi refers to a group of fungi of the genus Claviceps.
In molecular biology, extracellular signal–regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.
A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.
Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons.
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.
Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
In neuroscience, Golgi cells are inhibitory interneurons found within the granular layer of the cerebellum.
A GPCR oligomer is a protein complex that consists of a small number (ὀλίγοι oligoi "a few", μέρος méros "part, piece, component") of G protein-coupled receptors (GPCRs).
The head-twitch response (HTR) is a rapid side-to-side head movement that occurs in mice and rats after the serotonin 5-HT2A receptor is activated.
The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.
Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is a first-generation antihistamine.
Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene.
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
Inositol trisphosphate or inositol 1,4,5-trisphosphate (also commonly known as triphosphoinositol; abbreviated InsP3 or Ins3P or IP3), together with diacylglycerol (DAG), is a secondary messenger molecule used in signal transduction and lipid signaling in biological cells.
The internal granular layer of the cortex, also commonly referred to as the granular layer of the cortex, is the layer IV in the subdivision of the mammalian cortex into 6 layers.
International Immunology is a peer-reviewed medical journal published by Oxford University Press on behalf of the Japanese Society for Immunology, addressing studies in allergology and immunology.
An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.
Isotopic labeling (or isotopic labelling) is a technique used to track the passage of an isotope (an atom with a detectable variation) through a reaction, metabolic pathway, or cell.
The JC virus or John Cunningham virus is a type of human polyomavirus (formerly known as papovavirus).
Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former developmental code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonin system; specifically, the 5-HT2 receptor family.
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
Lipophilicity (from Greek λίπος "fat" and φίλος "friendly"), refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.
Lisuride, sold under the brand names Dopergin, Proclacam, and Revanil, is an antiparkinson agent of the iso-ergoline class, chemically related to the dopaminergic ergoline Parkinson's drugs.
LY-367,265 is a drug developed by Eli Lilly, which acts as both a potent and selective antagonist at the serotonin 5-HT2A receptor, and also a selective serotonin reuptake inhibitor (SSRI).
Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects, which may include altered awareness of one's surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not.
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
Mefloquine, sold under the brand names Lariam among others, is a medication used to prevent or treat malaria.
Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.
Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene.
Metabotropic glutamate receptor 5 is a G protein-coupled receptor that in humans is encoded by the GRM5 gene.
Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.
Methylergometrine (also called methylergonovine, methylergobasin, and D-lysergic acid 1-butanolamide) is a synthetic analogue of ergonovine, a psychedelic alkaloid found in ergot, and many species of morning glory.
Methysergide (1-methyl-D-lysergic acid butanolamide or UML-491) also known as methysergide maleate, is an ergot derived prescription drug used for the prophylaxis of difficult to treat migraine and cluster headaches.
A migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe.
Mirtazapine, sold under the brand name Remeron among others, is an atypical antidepressant which is used primarily in the treatment of depression.
Monocytes are a type of leukocyte, or white blood cell.
A monomer (mono-, "one" + -mer, "part") is a molecule that "can undergo polymerization thereby contributing constitutional units to the essential structure of a macromolecule".
Mood disorder, also known as mood (affective) disorders, is a group of conditions where a disturbance in the person's mood is the main underlying feature.
Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals.
A mouse (Mus), plural mice, is a small rodent characteristically having a pointed snout, small rounded ears, a body-length scaly tail and a high breeding rate.
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a tryptamine molecule which occurs in many plants and animals.
Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant which was first marketed by Bristol-Myers Squibb in 1994 but has since largely been discontinued.
Nelotanserin (former developmental code name APD-125) is a drug developed by Arena Pharmaceuticals which acts as an inverse agonist on the serotonin receptor subtype 5-HT2A and was under development for the treatment of insomnia.
The neocortex, also called the neopallium and isocortex, is the part of the mammalian brain involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language.
Neuroticism is one of the Big Five higher-order personality traits in the study of psychology.
Niaprazine (INN) (brand name Nopron) is a sedative-hypnotic drug of the phenylpiperazine group.
O-4310 (1-isopropyl-6-fluoro-psilocin) is a tryptamine derivative developed by Organix which acts as a serotonin receptor agonist.
Obsessive–compulsive disorder (OCD) is a mental disorder where people feel the need to check things repeatedly, perform certain routines repeatedly (called "rituals"), or have certain thoughts repeatedly (called "obsessions").
In statistics, the odds ratio (OR) is one of three main ways to quantify how strongly the presence or absence of property A is associated with the presence or absence of property B in a given population.
Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.
The olfactory tubercle (OT), also known as the tuberculum olfactorium, is a multi-sensory processing center that is contained within the olfactory cortex and ventral striatum and plays a role in reward cognition.
Oligodendrocytes, or oligodendroglia,.
OSU-6162 (PNU-96391) is a compound which acts as a partial agonist at both dopamine D2 receptors and 5-HT2A receptors.
Oxytocin (Oxt) is a peptide hormone and neuropeptide.
The parietal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The parietal lobe is positioned above the temporal lobe and behind the frontal lobe and central sulcus. The parietal lobe integrates sensory information among various modalities, including spatial sense and navigation (proprioception), the main sensory receptive area for the sense of touch (mechanoreception) in the somatosensory cortex which is just posterior to the central sulcus in the postcentral gyrus, and the dorsal stream of the visual system. The major sensory inputs from the skin (touch, temperature, and pain receptors), relay through the thalamus to the parietal lobe. Several areas of the parietal lobe are important in language processing. The somatosensory cortex can be illustrated as a distorted figure – the homunculus (Latin: "little man"), in which the body parts are rendered according to how much of the somatosensory cortex is devoted to them.Schacter, D. L., Gilbert, D. L. & Wegner, D. M. (2009). Psychology. (2nd ed.). New York (NY): Worth Publishers. The superior parietal lobule and inferior parietal lobule are the primary areas of body or spacial awareness. A lesion commonly in the right superior or inferior parietal lobule leads to hemineglect. The name comes from the parietal bone, which is named from the Latin paries-, meaning "wall".
PHA-57378 is a drug which acts as an agonist at serotonin 5-HT2 receptors, having a binding affinity of 4.1 nM at the 5-HT2A subtype and 4.3 nM at 5-HT2C.
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans.
Phenoxybenzamine (marketed under the trade name Dibenzyline) is a non-selective, irreversible alpha blocker.
Phospholipases A2 (PLA2s) are enzymes that release fatty acids from the second carbon group of glycerol.
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).
Phospholipase D (lipophosphodiesterase II, lecithinase D, choline phosphatase) (PLD) is an enzyme of the phospholipase superfamily.
Pimavanserin, sold under the brand name Nuplazid, is an atypical antipsychotic which is approved for the treatment of Parkinson's disease psychosis and is also under development for the treatment of schizophrenia, agitation, and major depressive disorder.
Pizotifen (INN) or pizotyline (USAN), trade name Sandomigran, is a benzocycloheptene-based drug used as a medicine, primarily as a preventative to reduce the frequency of recurrent migraine headaches.
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.
Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.
Polyomaviridae is a family of viruses whose natural hosts are primarily mammals and birds.
Positron-emission tomography (PET) is a nuclear medicine functional imaging technique that is used to observe metabolic processes in the body as an aid to the diagnosis of disease.
In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.
The primary somatosensory cortex is located in the postcentral gyrus, and is part of the somatosensory system.
Progressive multifocal leukoencephalopathy (PML) is a rare and usually fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal).
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that is best known for its role in enabling mammals, usually females, to produce milk.
Protein kinase C, commonly abbreviated to PKC (EC 126.96.36.199), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance.
Psychedelics are a class of drug whose primary action is to trigger psychedelic experiences via serotonin receptor agonism, causing thought and visual/auditory changes, and altered state of consciousness.
Purkinje cells, or Purkinje neurons, are a class of GABAergic neurons located in the cerebellum.
Pyramidal cells, or (pyramidal neurons), are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala.
Quetiapine, marketed as Seroquel among other names, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
A radioligand is a radioactive biochemical substance (in particular, a ligand that is radiolabeled) that is used for diagnosis or for research-oriented study of the receptor systems of the body.
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid), and arterial vasoconstriction.
The Revised NEO Personality Inventory (NEO PI-R) is a personality inventory that examines a person's Big Five personality traits (openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism).
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily.
Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases.
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
Ritanserin (INN, USAN, BAN) is a serotonin receptor antagonist which was never marketed for clinical use but has been used in scientific research.
In genetics rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor.
In genetics, rs6313 also called T102C or C102T is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor.
In genetics, rs6314, also called His452Tyr or H452Y, is a gene variation, a single nucleotide polymorphism (SNP), in the HTR2A gene that codes for the 5-HT2A receptor.
In genetics, rs7997012 is a gene variation—a single nucleotide polymorphism (SNP)—in intron 2 of the human HTR2A gene that codes for the 5-HT2A receptor.
Sanofi S.A. is a French multinational pharmaceutical company headquartered in Gentilly, France, as of 2013 the world's fifth-largest by prescription sales.
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
Schizophrenia Research Forum is a web knowledge environment dedicated to news, information resources, and discussion about research on schizophrenia.
Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers.
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone.
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).
Spiperone (Spiroperidol; brand name: Spiropitan (JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class.
commented out as it doesn't appear to be immediately relevant & it is in the wrong place if it is relevant-->The structure–activity relationship (SAR) is the relationship between the chemical or 3D structure of a molecule and its biological activity.
Suicide is the act of intentionally causing one's own death.
TCB-2 is a hallucinogen discovered in 2006 by Thomas McLean working in the lab of David Nichols at Purdue University where it was named 2C-BCB.
Tourette syndrome (TS or simply Tourette's) is a common neuropsychiatric disorder with onset in childhood, characterized by multiple motor tics and at least one vocal (phonic) tic.
Trazodone, sold under many brand names worldwide, Page accessed Feb 10, 2016 is an antidepressant medication.
Tryptamine is a monoamine alkaloid.
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.
Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles.
Vasodilation is the widening of blood vessels.
The visual cortex of the brain is a part of the cerebral cortex that processes visual information.
Volinanserin (INN) (developmental code name MDL-100,907) is a highly selective 5-HT2A receptor antagonist that is frequently used in scientific research to investigate the function of the 5-HT2A receptor.
2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug and a substituted amphetamine.
25B-NBOMe (NBOMe-2C-B, Cimbi-36, Nova, BOM 2-CB) is a derivative of the phenethylamine psychedelic 2C-B, discovered in 2004 by Ralf Heim at the Free University of Berlin.
25C-NBOMe (NBOMe-2C-C, 2C-C-NBOMe, Cimbi-82) is a psychedelic drug and derivative of the psychedelic phenethylamine 2C-C. 25C-NBOMe appeared on online vendor sites in 2010 but was not reported in the literature until 2011.
25CN-NBOH (or NBOH-2C-CN) is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2014 by at the University of Copenhagen.
25I-NBOH (NBOH-2CI, Cimbi-27, 2-C-I-NBOH) is a derivative of the phenethylamine-derived hallucinogen 2C-I that was discovered in 2006 by a team at Purdue University.
25I-NBOMe (2C-I-NBOMe, Cimbi-5, also shortened to "25I") is a psychedelic hallucinogen that is used in biochemistry research for mapping the brains usage of the type 2A serotonin receptor and later also has been used for recreational purpose.
2C-N, or 2,5-dimethoxy-4-nitrophenethylamine, is a psychedelic phenethylamine of the 2C family.
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT).
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
5-MeO-NBpBrT (5-Methoxy-N-(4-bromobenzyl)tryptamine) is a N-substituted member of the methoxytryptamine family of compounds.
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin.
AMDA (9-Aminomethyl-9,10-dihydroanthracene) is an organic compound which acts as a potent and selective antagonist for the 5-HT2A receptor.
5-HT2A, 5-HT2A antagonists, 5-HT2a receptor, 5-ht2a, 5-hydroxytryptamine receptor 2A, 5HT2A, 5HT2A agonist, 5HT2A receptor, 5ht2a, HTR2, HTR2A, HTR2A (gene), JVC receptor, Receptor, serotonin, 5-ht2a, Receptors, serotonin, 5-ht2, Serotonin 2A receptor, Serotonin-2A receptor.