Logo
Unionpedia
Communication
Get it on Google Play
New! Download Unionpedia on your Android™ device!
Install
Faster access than browser!
 

5-HT2C receptor

+ Save concept

The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). [1]

166 relations: A-372159, ADAR, ADARB1, ADARB2, Adenosine deaminase, Adrenocorticotropic hormone, Agomelatine, AL-38022A, Amitriptyline, Amoxapine, Amphetamine, Amygdala, Anatomical terms of location, Anterior olfactory nucleus, Antidepressant, Antihistamine, Antipsychotic, Anxiety/aggression-driven depression, Aripiprazole, Atypical antipsychotic, Brainstem, Bufotenin, Caffeine, Chlorpromazine, Choroid plexus, Cinanserin, Clomipramine, Clozapine, Cocaine, Corticotropin-releasing hormone, CP-809101, Cyproheptadine, Cytokine, Deramciclane, Desmetramadol, Dopamine, Downregulation and upregulation, Doxepin, Eltoprazine, Endogeny (biology), Estradiol, Etoperidone, Excitatory postsynaptic potential, Fenfluramine, Fight-or-flight response, Fluoxetine, Fluphenazine, G protein–coupled receptor, Gene, GPCR oligomer, ..., Gq alpha subunit, Guanosine, Hippocampus, Human, Hydroxyzine, Hypothalamic–pituitary–adrenal axis, Hypothalamus, Imipramine, Inosine, Intron, Inverse agonist, Ketanserin, Latrepirdine, Ligand (biochemistry), Lisuride, Lorcaserin, Loxapine, Lysergamides, Lysergic acid diethylamide, Mescaline, Mesulergine, Meta-Chlorophenylpiperazine, Metergoline, Methysergide, Metitepine, Mianserin, Mirtazapine, MK-212, Morphine, MPDZ, N,N-Dimethyltryptamine, Naphthylaminopropane, Nefazodone, Neurotransmission, Neurotransmitter, Nicotine, Norepinephrine, Norepinephrine–dopamine disinhibitor, Norfenfluramine, Nortriptyline, Nucleus accumbens, Olanzapine, ORG-12962, ORG-37684, Oxaflozane, Oxytocin, Paraventricular nucleus of hypothalamus, Paroxetine, Piperazine, Pituitary gland, Pizotifen, PNU-181731, PNU-22394, Prader–Willi syndrome, Precursor mRNA, Prefrontal cortex, Progesterone, Prolactin, Protein–protein interaction, Psilocin, Psychedelic drug, Quetiapine, Receptor (biochemistry), Receptor antagonist, Retrotransposon, Reuptake, Risperidone, Ritanserin, RNA editing, Ro60-0175, RS-102221, SB-200646, SB-206553, SB-242084, SB-243213, SDZ SER-082, Selective serotonin reuptake inhibitor, Seproxetine, Serotonin, Serotonin–norepinephrine reuptake inhibitor, Sertraline, Side effect, Small nucleolar RNA, Small nucleolar RNA SNORD115, Striatum, Substantia nigra, Substituted phenethylamine, Subthalamic nucleus, Sympathetic nervous system, Synapse, Tedatioxetine, Tetracyclic antidepressant, Thioridazine, TPH2, Tramadol, Trazodone, Tricyclic antidepressant, Trifluoromethylphenylpiperazine, Tryptamine, Typical antipsychotic, Untranslated region, Vabicaserin, Vasopressin, Venlafaxine, Ventricular system, WAY-161503, WAY-629, YM-348, Ziprasidone, 2,5-Dimethoxy-4-iodoamphetamine, 2,5-Dimethoxy-4-methylamphetamine, 2C-B, 5-HT receptor, 5-HT2 receptor, 5-MeO-DMT, 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide. Expand index (116 more) »

A-372159

A-372159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM.

New!!: 5-HT2C receptor and A-372159 · See more »

ADAR

Double-stranded RNA-specific adenosine deaminase is an enzyme that in humans is encoded by the ADAR gene (which stands for adenosine deaminase acting on RNA).

New!!: 5-HT2C receptor and ADAR · See more »

ADARB1

Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.

New!!: 5-HT2C receptor and ADARB1 · See more »

ADARB2

Double-stranded RNA-specific editase B2 is an enzyme that in humans is encoded by the ADARB2 gene.

New!!: 5-HT2C receptor and ADARB2 · See more »

Adenosine deaminase

Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme involved in purine metabolism.

New!!: 5-HT2C receptor and Adenosine deaminase · See more »

Adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.

New!!: 5-HT2C receptor and Adrenocorticotropic hormone · See more »

Agomelatine

Agomelatine (brand names Valdoxan, Melitor, Thymanax) is an atypical antidepressant developed by the pharmaceutical company Servier.

New!!: 5-HT2C receptor and Agomelatine · See more »

AL-38022A

AL-38022A is an indazole derivative drug which is one of a range of similar drugs developed for scientific research and with some possible clinical applications.

New!!: 5-HT2C receptor and AL-38022A · See more »

Amitriptyline

Amitriptyline, sold under the brand name Elavil among others, is a medicine primarily used to treat a number of mental illnesses.

New!!: 5-HT2C receptor and Amitriptyline · See more »

Amoxapine

Amoxapine, sold under the brand name Asendin among others, is a tetracyclic antidepressant (TeCA), though it is often classified as a tricyclic antidepressant (TCA).

New!!: 5-HT2C receptor and Amoxapine · See more »

Amphetamine

Amphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.

New!!: 5-HT2C receptor and Amphetamine · See more »

Amygdala

The amygdala (plural: amygdalae; also corpus amygdaloideum; Latin from Greek, ἀμυγδαλή, amygdalē, 'Almond', 'tonsil') is one of two almond-shaped groups of nuclei located deep and medially within the temporal lobes of the brain in complex vertebrates, including humans.

New!!: 5-HT2C receptor and Amygdala · See more »

Anatomical terms of location

Standard anatomical terms of location deal unambiguously with the anatomy of animals, including humans.

New!!: 5-HT2C receptor and Anatomical terms of location · See more »

Anterior olfactory nucleus

The anterior olfactory nucleus (AON; also called the anterior olfactory cortex) is a portion of the forebrain of vertebrates.

New!!: 5-HT2C receptor and Anterior olfactory nucleus · See more »

Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

New!!: 5-HT2C receptor and Antidepressant · See more »

Antihistamine

Antihistamines are drugs which treat allergic rhinitis and other allergies.

New!!: 5-HT2C receptor and Antihistamine · See more »

Antipsychotic

Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.

New!!: 5-HT2C receptor and Antipsychotic · See more »

Anxiety/aggression-driven depression

Anxiety/aggression-driven depression (also known as 5-HT related depression) is a proposed subtype of Major depressive disorder first proposed by the Dutch psychiatrist Herman M. van Praag in 1996.

New!!: 5-HT2C receptor and Anxiety/aggression-driven depression · See more »

Aripiprazole

Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. According to a Cochrane review, evidence for the oral form in schizophrenia is not sufficient to determine effects on general functioning. Additionally, because many people dropped out of the medication trials before they were completed, the overall strength of the conclusions is low. Side effects include neuroleptic malignant syndrome, a movement disorder known as tardive dyskinesia, and high blood sugar in those with diabetes. In the elderly there is an increased risk of death. It is thus not recommended for use in those with psychosis due to dementia. It is pregnancy category C in the United States and category C in Australia, meaning there is possible evidence of harm to the fetus. It is not recommended for women who are breastfeeding. It is unclear whether it is safe or effective in people less than 18 years old. It is a partial dopamine agonist. Aripiprazole was developed by Otsuka in Japan. In the United States, Otsuka America markets it jointly with Bristol-Myers Squibb. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.

New!!: 5-HT2C receptor and Aripiprazole · See more »

Atypical antipsychotic

The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.

New!!: 5-HT2C receptor and Atypical antipsychotic · See more »

Brainstem

The brainstem (or brain stem) is the posterior part of the brain, adjoining and structurally continuous with the spinal cord.

New!!: 5-HT2C receptor and Brainstem · See more »

Bufotenin

Bufotenin (5-HO-DMT, bufotenine) is a tryptamine related to the neurotransmitter serotonin.

New!!: 5-HT2C receptor and Bufotenin · See more »

Caffeine

Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class.

New!!: 5-HT2C receptor and Caffeine · See more »

Chlorpromazine

Chlorpromazine (CPZ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication.

New!!: 5-HT2C receptor and Chlorpromazine · See more »

Choroid plexus

The choroid plexus is a plexus of cells that produces the cerebrospinal fluid in the ventricles of the brain.

New!!: 5-HT2C receptor and Choroid plexus · See more »

Cinanserin

Cinanserin (INN) is a 5-HT2A and 5-HT2C receptor antagonist which was discovered in the 1960s.

New!!: 5-HT2C receptor and Cinanserin · See more »

Clomipramine

Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).

New!!: 5-HT2C receptor and Clomipramine · See more »

Clozapine

Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.

New!!: 5-HT2C receptor and Clozapine · See more »

Cocaine

Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.

New!!: 5-HT2C receptor and Cocaine · See more »

Corticotropin-releasing hormone

Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in the stress response.

New!!: 5-HT2C receptor and Corticotropin-releasing hormone · See more »

CP-809101

CP-809101 is a drug which acts as a potent and selective 5-HT2C receptor agonist.

New!!: 5-HT2C receptor and CP-809101 · See more »

Cyproheptadine

Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.

New!!: 5-HT2C receptor and Cyproheptadine · See more »

Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

New!!: 5-HT2C receptor and Cytokine · See more »

Deramciclane

Deramciclane (EGIS-3886) is a non-benzodiazepine-type anxiolytic drug to treat various types of anxiety disorders.

New!!: 5-HT2C receptor and Deramciclane · See more »

Desmetramadol

Desmetramadol, also known as O-desmethyltramadol (O-DSMT), is an opioid analgesic and the main active metabolite of tramadol.

New!!: 5-HT2C receptor and Desmetramadol · See more »

Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

New!!: 5-HT2C receptor and Dopamine · See more »

Downregulation and upregulation

In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus.

New!!: 5-HT2C receptor and Downregulation and upregulation · See more »

Doxepin

Doxepin is a tricyclic antidepressant (TCA) used as a pill to treat major depressive disorder, anxiety disorders, chronic hives, and for short-term help with trouble remaining asleep after going to bed (a form of insomnia).

New!!: 5-HT2C receptor and Doxepin · See more »

Eltoprazine

Eltoprazine (DU-28,853) is a drug of the phenylpiperazine class which is a serenic or antiaggressive agent.

New!!: 5-HT2C receptor and Eltoprazine · See more »

Endogeny (biology)

Endogenous substances and processes are those that originate from within an organism, tissue, or cell.

New!!: 5-HT2C receptor and Endogeny (biology) · See more »

Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.

New!!: 5-HT2C receptor and Estradiol · See more »

Etoperidone

Etoperidone, associated with several brand names, is an atypical antidepressant which was developed in the 1970s and either is no longer marketed or was never marketed.

New!!: 5-HT2C receptor and Etoperidone · See more »

Excitatory postsynaptic potential

In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential.

New!!: 5-HT2C receptor and Excitatory postsynaptic potential · See more »

Fenfluramine

Fenfluramine, formerly sold under the brand name Pondimin among others, is an appetite suppressant which was used to treat obesity and is now no longer marketed.

New!!: 5-HT2C receptor and Fenfluramine · See more »

Fight-or-flight response

The fight-or-flight response (also called hyperarousal, or the acute stress response) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival.

New!!: 5-HT2C receptor and Fight-or-flight response · See more »

Fluoxetine

Fluoxetine, also known by trade names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

New!!: 5-HT2C receptor and Fluoxetine · See more »

Fluphenazine

Fluphenazine, sold under the brand names Prolixin among others, is an antipsychotic medication.

New!!: 5-HT2C receptor and Fluphenazine · See more »

G protein–coupled receptor

G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.

New!!: 5-HT2C receptor and G protein–coupled receptor · See more »

Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

New!!: 5-HT2C receptor and Gene · See more »

GPCR oligomer

A GPCR oligomer is a protein complex that consists of a small number (ὀλίγοι oligoi "a few", μέρος méros "part, piece, component") of G protein-coupled receptors (GPCRs).

New!!: 5-HT2C receptor and GPCR oligomer · See more »

Gq alpha subunit

Gq protein (Gαq, or Gq/11) is a heterotrimeric G protein subunit that activates phospholipase C (PLC).

New!!: 5-HT2C receptor and Gq alpha subunit · See more »

Guanosine

Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.

New!!: 5-HT2C receptor and Guanosine · See more »

Hippocampus

The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.

New!!: 5-HT2C receptor and Hippocampus · See more »

Human

Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.

New!!: 5-HT2C receptor and Human · See more »

Hydroxyzine

Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is a first-generation antihistamine.

New!!: 5-HT2C receptor and Hydroxyzine · See more »

Hypothalamic–pituitary–adrenal axis

The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus, the pituitary gland (a pea-shaped structure located below the thalamus), and the adrenal (also called "suprarenal") glands (small, conical organs on top of the kidneys).

New!!: 5-HT2C receptor and Hypothalamic–pituitary–adrenal axis · See more »

Hypothalamus

The hypothalamus(from Greek ὑπό, "under" and θάλαμος, thalamus) is a portion of the brain that contains a number of small nuclei with a variety of functions.

New!!: 5-HT2C receptor and Hypothalamus · See more »

Imipramine

Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression.

New!!: 5-HT2C receptor and Imipramine · See more »

Inosine

Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.

New!!: 5-HT2C receptor and Inosine · See more »

Intron

An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.

New!!: 5-HT2C receptor and Intron · See more »

Inverse agonist

In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.

New!!: 5-HT2C receptor and Inverse agonist · See more »

Ketanserin

Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former developmental code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonin system; specifically, the 5-HT2 receptor family.

New!!: 5-HT2C receptor and Ketanserin · See more »

Latrepirdine

Latrepirdine (INN, also known as dimebolin and sold as Dimebon), is an antihistamine drug which has been used clinically in Russia since 1983.

New!!: 5-HT2C receptor and Latrepirdine · See more »

Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

New!!: 5-HT2C receptor and Ligand (biochemistry) · See more »

Lisuride

Lisuride, sold under the brand names Dopergin, Proclacam, and Revanil, is an antiparkinson agent of the iso-ergoline class, chemically related to the dopaminergic ergoline Parkinson's drugs.

New!!: 5-HT2C receptor and Lisuride · See more »

Lorcaserin

Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development, is a weight-loss drug developed by Arena Pharmaceuticals.

New!!: 5-HT2C receptor and Lorcaserin · See more »

Loxapine

Loxapine (several trade names worldwide) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia.

New!!: 5-HT2C receptor and Loxapine · See more »

Lysergamides

Amides of lysergic acid are collectively known as lysergamides.

New!!: 5-HT2C receptor and Lysergamides · See more »

Lysergic acid diethylamide

Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects, which may include altered awareness of one's surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not.

New!!: 5-HT2C receptor and Lysergic acid diethylamide · See more »

Mescaline

Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.

New!!: 5-HT2C receptor and Mescaline · See more »

Mesulergine

No description.

New!!: 5-HT2C receptor and Mesulergine · See more »

Meta-Chlorophenylpiperazine

meta-Chlorophenylpiperazine (mCPP) is a psychoactive drug of the phenylpiperazine class.

New!!: 5-HT2C receptor and Meta-Chlorophenylpiperazine · See more »

Metergoline

Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.

New!!: 5-HT2C receptor and Metergoline · See more »

Methysergide

Methysergide (1-methyl-D-lysergic acid butanolamide or UML-491) also known as methysergide maleate, is an ergot derived prescription drug used for the prophylaxis of difficult to treat migraine and cluster headaches.

New!!: 5-HT2C receptor and Methysergide · See more »

Metitepine

Metitepine (developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic group which was never marketed.

New!!: 5-HT2C receptor and Metitepine · See more »

Mianserin

Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant which is used in the treatment of depression in Europe and elsewhere in the world.

New!!: 5-HT2C receptor and Mianserin · See more »

Mirtazapine

Mirtazapine, sold under the brand name Remeron among others, is an atypical antidepressant which is used primarily in the treatment of depression.

New!!: 5-HT2C receptor and Mirtazapine · See more »

MK-212

MK-212 (CPP or 6-chloro-2-(l-piperazinyl)pyrazine) is a serotonin agonist.

New!!: 5-HT2C receptor and MK-212 · See more »

Morphine

Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals.

New!!: 5-HT2C receptor and Morphine · See more »

MPDZ

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.

New!!: 5-HT2C receptor and MPDZ · See more »

N,N-Dimethyltryptamine

N,N-Dimethyltryptamine (DMT or N,N-DMT) is a tryptamine molecule which occurs in many plants and animals.

New!!: 5-HT2C receptor and N,N-Dimethyltryptamine · See more »

Naphthylaminopropane

Naphthylisopropylamine (PAL-287) is an experimental drug currently under investigation for the treatment of alcohol and stimulant addiction.

New!!: 5-HT2C receptor and Naphthylaminopropane · See more »

Nefazodone

Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant which was first marketed by Bristol-Myers Squibb in 1994 but has since largely been discontinued.

New!!: 5-HT2C receptor and Nefazodone · See more »

Neurotransmission

Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).

New!!: 5-HT2C receptor and Neurotransmission · See more »

Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

New!!: 5-HT2C receptor and Neurotransmitter · See more »

Nicotine

Nicotine is a potent parasympathomimetic stimulant and an alkaloid found in the nightshade family of plants.

New!!: 5-HT2C receptor and Nicotine · See more »

Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

New!!: 5-HT2C receptor and Norepinephrine · See more »

Norepinephrine–dopamine disinhibitor

Norepinephrine and dopamine disinhibitors (NDDIs) are a class of drugs which act at specific sites to disinhibit downstream norepinephrine and dopamine release in the brain.

New!!: 5-HT2C receptor and Norepinephrine–dopamine disinhibitor · See more »

Norfenfluramine

Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist.

New!!: 5-HT2C receptor and Norfenfluramine · See more »

Nortriptyline

Nortriptyline, sold under the brand names Allegron, Aventyl, Noritren, Nortrilen, and Pamelor among others, is a tricyclic antidepressant (TCA) used to treat clinical depression.

New!!: 5-HT2C receptor and Nortriptyline · See more »

Nucleus accumbens

The nucleus accumbens (NAc or NAcc), also known as the accumbens nucleus, or formerly as the nucleus accumbens septi (Latin for nucleus adjacent to the septum) is a region in the basal forebrain rostral to the preoptic area of the hypothalamus.

New!!: 5-HT2C receptor and Nucleus accumbens · See more »

Olanzapine

Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.

New!!: 5-HT2C receptor and Olanzapine · See more »

ORG-12962

ORG-12962 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.

New!!: 5-HT2C receptor and ORG-12962 · See more »

ORG-37684

ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.

New!!: 5-HT2C receptor and ORG-37684 · See more »

Oxaflozane

Oxaflozane (INN) (brand name Conflictan) is an antidepressant and anxiolytic drug that was introduced by Solvay in France in 1982 for the treatment of depression but has since been discontinued.

New!!: 5-HT2C receptor and Oxaflozane · See more »

Oxytocin

Oxytocin (Oxt) is a peptide hormone and neuropeptide.

New!!: 5-HT2C receptor and Oxytocin · See more »

Paraventricular nucleus of hypothalamus

The paraventricular nucleus (PVN, PVA, or PVH) is a nucleus in the hypothalamus.

New!!: 5-HT2C receptor and Paraventricular nucleus of hypothalamus · See more »

Paroxetine

Paroxetine, also known by trade names including Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. It has a similar tolerability profile to other SSRIs. The common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping and delayed ejaculation. It may also be associated with a slightly increased risk of birth defects. The rate of withdrawal symptoms in young people may be higher with paroxetine and venlafaxine than other SSRIs and SNRIs. Several studies have associated paroxetine with suicidal thinking and behavior in children and adolescents. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired. The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression.

New!!: 5-HT2C receptor and Paroxetine · See more »

Piperazine

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring.

New!!: 5-HT2C receptor and Piperazine · See more »

Pituitary gland

An explanation of the development of the pituitary gland (Hypophysis cerebri) & the congenital anomalies. In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing in humans.

New!!: 5-HT2C receptor and Pituitary gland · See more »

Pizotifen

Pizotifen (INN) or pizotyline (USAN), trade name Sandomigran, is a benzocycloheptene-based drug used as a medicine, primarily as a preventative to reduce the frequency of recurrent migraine headaches.

New!!: 5-HT2C receptor and Pizotifen · See more »

PNU-181731

PNU-181731 is a drug which acts as an agonist at serotonin 5-HT2 receptors, with strongest binding affinity for the 5-HT2C subtype at 4.8nM, and weaker 5-HT2A affinity of 18nM.

New!!: 5-HT2C receptor and PNU-181731 · See more »

PNU-22394

PNU-22394 is a drug which acts as an agonist at serotonin 5-HT2 receptors, with strongest binding affinity for 5-HT2A and 5-HT2C and slightly weaker at 5-HT2B, although it is only a full agonist at 5-HT2C, but partial agonist at 5-HT2A and 5-HT2B.

New!!: 5-HT2C receptor and PNU-22394 · See more »

Prader–Willi syndrome

Prader–Willi syndrome (PWS) is a genetic disorder due to loss of function of specific genes.

New!!: 5-HT2C receptor and Prader–Willi syndrome · See more »

Precursor mRNA

Precursor mRNA (pre-mRNA) is an immature single strand of messenger ribonucleic acid (mRNA).

New!!: 5-HT2C receptor and Precursor mRNA · See more »

Prefrontal cortex

In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.

New!!: 5-HT2C receptor and Prefrontal cortex · See more »

Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

New!!: 5-HT2C receptor and Progesterone · See more »

Prolactin

Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that is best known for its role in enabling mammals, usually females, to produce milk.

New!!: 5-HT2C receptor and Prolactin · See more »

Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

New!!: 5-HT2C receptor and Protein–protein interaction · See more »

Psilocin

Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance.

New!!: 5-HT2C receptor and Psilocin · See more »

Psychedelic drug

Psychedelics are a class of drug whose primary action is to trigger psychedelic experiences via serotonin receptor agonism, causing thought and visual/auditory changes, and altered state of consciousness.

New!!: 5-HT2C receptor and Psychedelic drug · See more »

Quetiapine

Quetiapine, marketed as Seroquel among other names, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.

New!!: 5-HT2C receptor and Quetiapine · See more »

Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

New!!: 5-HT2C receptor and Receptor (biochemistry) · See more »

Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

New!!: 5-HT2C receptor and Receptor antagonist · See more »

Retrotransposon

Retrotransposons (also called transposons via RNA intermediates) are genetic elements that can amplify themselves in a genome and are ubiquitous components of the DNA of many eukaryotic organisms.

New!!: 5-HT2C receptor and Retrotransposon · See more »

Reuptake

Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

New!!: 5-HT2C receptor and Reuptake · See more »

Risperidone

Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.

New!!: 5-HT2C receptor and Risperidone · See more »

Ritanserin

Ritanserin (INN, USAN, BAN) is a serotonin receptor antagonist which was never marketed for clinical use but has been used in scientific research.

New!!: 5-HT2C receptor and Ritanserin · See more »

RNA editing

RNA editing is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase.

New!!: 5-HT2C receptor and RNA editing · See more »

Ro60-0175

Ro60-0175 is a drug developed by Hoffmann–La Roche, which has applications in scientific research.

New!!: 5-HT2C receptor and Ro60-0175 · See more »

RS-102221

RS-102221 is a drug developed by Hoffmann–La Roche, which was one of the first compounds discovered that acts as a potent and selective antagonist at the serotonin 5-HT2C receptor, with around 100x selectivity over the closely related 5-HT2A and 5-HT2B receptors. It has anxiolytic effects in animal studies, increases the effectiveness of SSRI antidepressants, and shows a complex interaction with cocaine, increasing some effects but decreasing others, reflecting a role for the 5-HT2C receptor in regulation of the dopamine signalling system in the brain.

New!!: 5-HT2C receptor and RS-102221 · See more »

SB-200646

SB-200646 is a 5-HT2 receptor antagonist with anxiolytic properties in rats.

New!!: 5-HT2C receptor and SB-200646 · See more »

SB-206553

SB-206553 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors.

New!!: 5-HT2C receptor and SB-206553 · See more »

SB-242084

SB-242084 is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor.

New!!: 5-HT2C receptor and SB-242084 · See more »

SB-243213

SB-243213 is a research chemical which acts as a selective inverse agonist for the 5HT2C receptor and has anxiolytic effects.

New!!: 5-HT2C receptor and SB-243213 · See more »

SDZ SER-082

SDZ SER-082 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.

New!!: 5-HT2C receptor and SDZ SER-082 · See more »

Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

New!!: 5-HT2C receptor and Selective serotonin reuptake inhibitor · See more »

Seproxetine

Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI).

New!!: 5-HT2C receptor and Seproxetine · See more »

Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

New!!: 5-HT2C receptor and Serotonin · See more »

Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.

New!!: 5-HT2C receptor and Serotonin–norepinephrine reuptake inhibitor · See more »

Sertraline

Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

New!!: 5-HT2C receptor and Sertraline · See more »

Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

New!!: 5-HT2C receptor and Side effect · See more »

Small nucleolar RNA

Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs.

New!!: 5-HT2C receptor and Small nucleolar RNA · See more »

Small nucleolar RNA SNORD115

SNORD115 (also known as HBII-52) is a non-coding RNA (ncRNA) molecule known as a small nucleolar RNA which usually functions in guiding the modification of other non-coding RNAs.

New!!: 5-HT2C receptor and Small nucleolar RNA SNORD115 · See more »

Striatum

The striatum, or corpus striatum (also called the neostriatum and the striate nucleus) is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain.

New!!: 5-HT2C receptor and Striatum · See more »

Substantia nigra

The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement.

New!!: 5-HT2C receptor and Substantia nigra · See more »

Substituted phenethylamine

Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents.

New!!: 5-HT2C receptor and Substituted phenethylamine · See more »

Subthalamic nucleus

The subthalamic nucleus is a small lens-shaped nucleus in the brain where it is, from a functional point of view, part of the basal ganglia system.

New!!: 5-HT2C receptor and Subthalamic nucleus · See more »

Sympathetic nervous system

The sympathetic nervous system (SNS) is one of the two main divisions of the autonomic nervous system, the other being the parasympathetic nervous system.

New!!: 5-HT2C receptor and Sympathetic nervous system · See more »

Synapse

In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target efferent cell.

New!!: 5-HT2C receptor and Synapse · See more »

Tedatioxetine

Tedatioxetine (Lu AA24530) is an antidepressant that was discovered by scientists at Lundbeck; in 2007 Lundbeck and Takeda entered into a partnership that included tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine.

New!!: 5-HT2C receptor and Tedatioxetine · See more »

Tetracyclic antidepressant

Tetracyclic antidepressants (TeCAs) are a class of antidepressants that were first introduced starting in the 1970s.

New!!: 5-HT2C receptor and Tetracyclic antidepressant · See more »

Thioridazine

Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis.

New!!: 5-HT2C receptor and Thioridazine · See more »

TPH2

Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates.

New!!: 5-HT2C receptor and TPH2 · See more »

Tramadol

Tramadol, sold under the brand name Ultram among others, is an opioid pain medication used to treat moderate to moderately severe pain.

New!!: 5-HT2C receptor and Tramadol · See more »

Trazodone

Trazodone, sold under many brand names worldwide, Page accessed Feb 10, 2016 is an antidepressant medication.

New!!: 5-HT2C receptor and Trazodone · See more »

Tricyclic antidepressant

Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.

New!!: 5-HT2C receptor and Tricyclic antidepressant · See more »

Trifluoromethylphenylpiperazine

3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the piperazine chemical class.

New!!: 5-HT2C receptor and Trifluoromethylphenylpiperazine · See more »

Tryptamine

Tryptamine is a monoamine alkaloid.

New!!: 5-HT2C receptor and Tryptamine · See more »

Typical antipsychotic

Typical antipsychotics are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia).

New!!: 5-HT2C receptor and Typical antipsychotic · See more »

Untranslated region

In molecular genetics, an untranslated region (or UTR) refers to either of two sections, one on each side of a coding sequence on a strand of mRNA.

New!!: 5-HT2C receptor and Untranslated region · See more »

Vabicaserin

Vabicaserin (codenamed SCA-136) was a novel antipsychotic and anorectic under development by Wyeth.

New!!: 5-HT2C receptor and Vabicaserin · See more »

Vasopressin

Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP.

New!!: 5-HT2C receptor and Vasopressin · See more »

Venlafaxine

Venlafaxine, sold under the brand name Effexor among others, is an antidepressant of the selective serotonin-norepinephrine reuptake inhibitor (SNRI) class.

New!!: 5-HT2C receptor and Venlafaxine · See more »

Ventricular system

The ventricular system is a set of four interconnected cavities (ventricles) in the brain, where the cerebrospinal fluid (CSF) is produced.

New!!: 5-HT2C receptor and Ventricular system · See more »

WAY-161503

WAY-161503 is a full agonist of 5-HT2C receptors (Ki.

New!!: 5-HT2C receptor and WAY-161503 · See more »

WAY-629

WAY-629 is a 5-HT2C agonist that reduces feeding behavior when administered to rats.

New!!: 5-HT2C receptor and WAY-629 · See more »

YM-348

YM-348 is an indazole derivative drug which acts as a potent and selective 5-HT2C receptor agonist, with an EC50 of 1nM and 15x selectivity over 5-HT2A, although it only has moderate selectivity of 3x over the closely related 5-HT2B receptor.

New!!: 5-HT2C receptor and YM-348 · See more »

Ziprasidone

Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic which is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder.

New!!: 5-HT2C receptor and Ziprasidone · See more »

2,5-Dimethoxy-4-iodoamphetamine

2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug and a substituted amphetamine.

New!!: 5-HT2C receptor and 2,5-Dimethoxy-4-iodoamphetamine · See more »

2,5-Dimethoxy-4-methylamphetamine

2,5-Dimethoxy-4-methylamphetamine (DOM; known on the street as STP, standing for "Serenity, Tranquility and Peace") is a psychedelic and a substituted amphetamine.

New!!: 5-HT2C receptor and 2,5-Dimethoxy-4-methylamphetamine · See more »

2C-B

2C-B or 2,5-dimethoxy-4-bromophenethylamine is a psychedelic drug of the 2C family.

New!!: 5-HT2C receptor and 2C-B · See more »

5-HT receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.

New!!: 5-HT2C receptor and 5-HT receptor · See more »

5-HT2 receptor

The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

New!!: 5-HT2C receptor and 5-HT2 receptor · See more »

5-MeO-DMT

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is a psychedelic of the tryptamine class.

New!!: 5-HT2C receptor and 5-MeO-DMT · See more »

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide (CEPC) is a drug which acts as a potent and selective antagonist for the serotonin 5-HT2C receptor.

New!!: 5-HT2C receptor and 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide · See more »

Redirects here:

5-HT receptor 2C, 5-HT1C, 5-HT1C receptor, 5-HT2C, 5HT2C receptor, HTR2C, HTR2C (gene).

References

[1] https://en.wikipedia.org/wiki/5-HT2C_receptor

OutgoingIncoming
Hey! We are on Facebook now! »