166 relations: A-372159, ADAR, ADARB1, ADARB2, Adenosine deaminase, Adrenocorticotropic hormone, Agomelatine, AL-38022A, Amitriptyline, Amoxapine, Amphetamine, Amygdala, Anatomical terms of location, Anterior olfactory nucleus, Antidepressant, Antihistamine, Antipsychotic, Anxiety/aggression-driven depression, Aripiprazole, Atypical antipsychotic, Brainstem, Bufotenin, Caffeine, Chlorpromazine, Choroid plexus, Cinanserin, Clomipramine, Clozapine, Cocaine, Corticotropin-releasing hormone, CP-809101, Cyproheptadine, Cytokine, Deramciclane, Desmetramadol, Dopamine, Downregulation and upregulation, Doxepin, Eltoprazine, Endogeny (biology), Estradiol, Etoperidone, Excitatory postsynaptic potential, Fenfluramine, Fight-or-flight response, Fluoxetine, Fluphenazine, G protein–coupled receptor, Gene, GPCR oligomer, ..., Gq alpha subunit, Guanosine, Hippocampus, Human, Hydroxyzine, Hypothalamic–pituitary–adrenal axis, Hypothalamus, Imipramine, Inosine, Intron, Inverse agonist, Ketanserin, Latrepirdine, Ligand (biochemistry), Lisuride, Lorcaserin, Loxapine, Lysergamides, Lysergic acid diethylamide, Mescaline, Mesulergine, Meta-Chlorophenylpiperazine, Metergoline, Methysergide, Metitepine, Mianserin, Mirtazapine, MK-212, Morphine, MPDZ, N,N-Dimethyltryptamine, Naphthylaminopropane, Nefazodone, Neurotransmission, Neurotransmitter, Nicotine, Norepinephrine, Norepinephrine–dopamine disinhibitor, Norfenfluramine, Nortriptyline, Nucleus accumbens, Olanzapine, ORG-12962, ORG-37684, Oxaflozane, Oxytocin, Paraventricular nucleus of hypothalamus, Paroxetine, Piperazine, Pituitary gland, Pizotifen, PNU-181731, PNU-22394, Prader–Willi syndrome, Precursor mRNA, Prefrontal cortex, Progesterone, Prolactin, Protein–protein interaction, Psilocin, Psychedelic drug, Quetiapine, Receptor (biochemistry), Receptor antagonist, Retrotransposon, Reuptake, Risperidone, Ritanserin, RNA editing, Ro60-0175, RS-102221, SB-200646, SB-206553, SB-242084, SB-243213, SDZ SER-082, Selective serotonin reuptake inhibitor, Seproxetine, Serotonin, Serotonin–norepinephrine reuptake inhibitor, Sertraline, Side effect, Small nucleolar RNA, Small nucleolar RNA SNORD115, Striatum, Substantia nigra, Substituted phenethylamine, Subthalamic nucleus, Sympathetic nervous system, Synapse, Tedatioxetine, Tetracyclic antidepressant, Thioridazine, TPH2, Tramadol, Trazodone, Tricyclic antidepressant, Trifluoromethylphenylpiperazine, Tryptamine, Typical antipsychotic, Untranslated region, Vabicaserin, Vasopressin, Venlafaxine, Ventricular system, WAY-161503, WAY-629, YM-348, Ziprasidone, 2,5-Dimethoxy-4-iodoamphetamine, 2,5-Dimethoxy-4-methylamphetamine, 2C-B, 5-HT receptor, 5-HT2 receptor, 5-MeO-DMT, 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide. Expand index (116 more) » « Shrink index
A-372159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM.
Double-stranded RNA-specific adenosine deaminase is an enzyme that in humans is encoded by the ADAR gene (which stands for adenosine deaminase acting on RNA).
Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.
Double-stranded RNA-specific editase B2 is an enzyme that in humans is encoded by the ADARB2 gene.
Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme involved in purine metabolism.
Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.
Agomelatine (brand names Valdoxan, Melitor, Thymanax) is an atypical antidepressant developed by the pharmaceutical company Servier.
AL-38022A is an indazole derivative drug which is one of a range of similar drugs developed for scientific research and with some possible clinical applications.
Amitriptyline, sold under the brand name Elavil among others, is a medicine primarily used to treat a number of mental illnesses.
Amoxapine, sold under the brand name Asendin among others, is a tetracyclic antidepressant (TeCA), though it is often classified as a tricyclic antidepressant (TCA).
Amphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.
The amygdala (plural: amygdalae; also corpus amygdaloideum; Latin from Greek, ἀμυγδαλή, amygdalē, 'Almond', 'tonsil') is one of two almond-shaped groups of nuclei located deep and medially within the temporal lobes of the brain in complex vertebrates, including humans.
Standard anatomical terms of location deal unambiguously with the anatomy of animals, including humans.
The anterior olfactory nucleus (AON; also called the anterior olfactory cortex) is a portion of the forebrain of vertebrates.
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
Antihistamines are drugs which treat allergic rhinitis and other allergies.
Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.
Anxiety/aggression-driven depression (also known as 5-HT related depression) is a proposed subtype of Major depressive disorder first proposed by the Dutch psychiatrist Herman M. van Praag in 1996.
Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. According to a Cochrane review, evidence for the oral form in schizophrenia is not sufficient to determine effects on general functioning. Additionally, because many people dropped out of the medication trials before they were completed, the overall strength of the conclusions is low. Side effects include neuroleptic malignant syndrome, a movement disorder known as tardive dyskinesia, and high blood sugar in those with diabetes. In the elderly there is an increased risk of death. It is thus not recommended for use in those with psychosis due to dementia. It is pregnancy category C in the United States and category C in Australia, meaning there is possible evidence of harm to the fetus. It is not recommended for women who are breastfeeding. It is unclear whether it is safe or effective in people less than 18 years old. It is a partial dopamine agonist. Aripiprazole was developed by Otsuka in Japan. In the United States, Otsuka America markets it jointly with Bristol-Myers Squibb. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.
The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.
The brainstem (or brain stem) is the posterior part of the brain, adjoining and structurally continuous with the spinal cord.
Bufotenin (5-HO-DMT, bufotenine) is a tryptamine related to the neurotransmitter serotonin.
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class.
Chlorpromazine (CPZ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication.
The choroid plexus is a plexus of cells that produces the cerebrospinal fluid in the ventricles of the brain.
Cinanserin (INN) is a 5-HT2A and 5-HT2C receptor antagonist which was discovered in the 1960s.
Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).
Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.
Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.
Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in the stress response.
CP-809101 is a drug which acts as a potent and selective 5-HT2C receptor agonist.
Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
Deramciclane (EGIS-3886) is a non-benzodiazepine-type anxiolytic drug to treat various types of anxiety disorders.
Desmetramadol, also known as O-desmethyltramadol (O-DSMT), is an opioid analgesic and the main active metabolite of tramadol.
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus.
Doxepin is a tricyclic antidepressant (TCA) used as a pill to treat major depressive disorder, anxiety disorders, chronic hives, and for short-term help with trouble remaining asleep after going to bed (a form of insomnia).
Eltoprazine (DU-28,853) is a drug of the phenylpiperazine class which is a serenic or antiaggressive agent.
Endogenous substances and processes are those that originate from within an organism, tissue, or cell.
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
Etoperidone, associated with several brand names, is an atypical antidepressant which was developed in the 1970s and either is no longer marketed or was never marketed.
In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential.
Fenfluramine, formerly sold under the brand name Pondimin among others, is an appetite suppressant which was used to treat obesity and is now no longer marketed.
The fight-or-flight response (also called hyperarousal, or the acute stress response) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival.
Fluoxetine, also known by trade names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
Fluphenazine, sold under the brand names Prolixin among others, is an antipsychotic medication.
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
A GPCR oligomer is a protein complex that consists of a small number (ὀλίγοι oligoi "a few", μέρος méros "part, piece, component") of G protein-coupled receptors (GPCRs).
Gq protein (Gαq, or Gq/11) is a heterotrimeric G protein subunit that activates phospholipase C (PLC).
Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.
The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.
Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.
Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is a first-generation antihistamine.
The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus, the pituitary gland (a pea-shaped structure located below the thalamus), and the adrenal (also called "suprarenal") glands (small, conical organs on top of the kidneys).
The hypothalamus(from Greek ὑπό, "under" and θάλαμος, thalamus) is a portion of the brain that contains a number of small nuclei with a variety of functions.
Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression.
Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.
An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.
Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former developmental code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonin system; specifically, the 5-HT2 receptor family.
Latrepirdine (INN, also known as dimebolin and sold as Dimebon), is an antihistamine drug which has been used clinically in Russia since 1983.
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
Lisuride, sold under the brand names Dopergin, Proclacam, and Revanil, is an antiparkinson agent of the iso-ergoline class, chemically related to the dopaminergic ergoline Parkinson's drugs.
Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development, is a weight-loss drug developed by Arena Pharmaceuticals.
Loxapine (several trade names worldwide) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia.
Amides of lysergic acid are collectively known as lysergamides.
Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects, which may include altered awareness of one's surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not.
Mescaline (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.
meta-Chlorophenylpiperazine (mCPP) is a psychoactive drug of the phenylpiperazine class.
Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.
Methysergide (1-methyl-D-lysergic acid butanolamide or UML-491) also known as methysergide maleate, is an ergot derived prescription drug used for the prophylaxis of difficult to treat migraine and cluster headaches.
Metitepine (developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic group which was never marketed.
Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant which is used in the treatment of depression in Europe and elsewhere in the world.
Mirtazapine, sold under the brand name Remeron among others, is an atypical antidepressant which is used primarily in the treatment of depression.
MK-212 (CPP or 6-chloro-2-(l-piperazinyl)pyrazine) is a serotonin agonist.
Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals.
Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a tryptamine molecule which occurs in many plants and animals.
Naphthylisopropylamine (PAL-287) is an experimental drug currently under investigation for the treatment of alcohol and stimulant addiction.
Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant which was first marketed by Bristol-Myers Squibb in 1994 but has since largely been discontinued.
Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).
Neurotransmitters are endogenous chemicals that enable neurotransmission.
Nicotine is a potent parasympathomimetic stimulant and an alkaloid found in the nightshade family of plants.
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
Norepinephrine and dopamine disinhibitors (NDDIs) are a class of drugs which act at specific sites to disinhibit downstream norepinephrine and dopamine release in the brain.
Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist.
Nortriptyline, sold under the brand names Allegron, Aventyl, Noritren, Nortrilen, and Pamelor among others, is a tricyclic antidepressant (TCA) used to treat clinical depression.
The nucleus accumbens (NAc or NAcc), also known as the accumbens nucleus, or formerly as the nucleus accumbens septi (Latin for nucleus adjacent to the septum) is a region in the basal forebrain rostral to the preoptic area of the hypothalamus.
Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.
ORG-12962 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.
ORG-37684 is a drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes.
Oxaflozane (INN) (brand name Conflictan) is an antidepressant and anxiolytic drug that was introduced by Solvay in France in 1982 for the treatment of depression but has since been discontinued.
Oxytocin (Oxt) is a peptide hormone and neuropeptide.
The paraventricular nucleus (PVN, PVA, or PVH) is a nucleus in the hypothalamus.
Paroxetine, also known by trade names including Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. It has a similar tolerability profile to other SSRIs. The common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping and delayed ejaculation. It may also be associated with a slightly increased risk of birth defects. The rate of withdrawal symptoms in young people may be higher with paroxetine and venlafaxine than other SSRIs and SNRIs. Several studies have associated paroxetine with suicidal thinking and behavior in children and adolescents. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired. The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression.
Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring.
An explanation of the development of the pituitary gland (Hypophysis cerebri) & the congenital anomalies. In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing in humans.
Pizotifen (INN) or pizotyline (USAN), trade name Sandomigran, is a benzocycloheptene-based drug used as a medicine, primarily as a preventative to reduce the frequency of recurrent migraine headaches.
PNU-181731 is a drug which acts as an agonist at serotonin 5-HT2 receptors, with strongest binding affinity for the 5-HT2C subtype at 4.8nM, and weaker 5-HT2A affinity of 18nM.
PNU-22394 is a drug which acts as an agonist at serotonin 5-HT2 receptors, with strongest binding affinity for 5-HT2A and 5-HT2C and slightly weaker at 5-HT2B, although it is only a full agonist at 5-HT2C, but partial agonist at 5-HT2A and 5-HT2B.
Prader–Willi syndrome (PWS) is a genetic disorder due to loss of function of specific genes.
Precursor mRNA (pre-mRNA) is an immature single strand of messenger ribonucleic acid (mRNA).
In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that is best known for its role in enabling mammals, usually females, to produce milk.
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance.
Psychedelics are a class of drug whose primary action is to trigger psychedelic experiences via serotonin receptor agonism, causing thought and visual/auditory changes, and altered state of consciousness.
Quetiapine, marketed as Seroquel among other names, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
Retrotransposons (also called transposons via RNA intermediates) are genetic elements that can amplify themselves in a genome and are ubiquitous components of the DNA of many eukaryotic organisms.
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
Ritanserin (INN, USAN, BAN) is a serotonin receptor antagonist which was never marketed for clinical use but has been used in scientific research.
RNA editing is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase.
Ro60-0175 is a drug developed by Hoffmann–La Roche, which has applications in scientific research.
RS-102221 is a drug developed by Hoffmann–La Roche, which was one of the first compounds discovered that acts as a potent and selective antagonist at the serotonin 5-HT2C receptor, with around 100x selectivity over the closely related 5-HT2A and 5-HT2B receptors. It has anxiolytic effects in animal studies, increases the effectiveness of SSRI antidepressants, and shows a complex interaction with cocaine, increasing some effects but decreasing others, reflecting a role for the 5-HT2C receptor in regulation of the dopamine signalling system in the brain.
SB-200646 is a 5-HT2 receptor antagonist with anxiolytic properties in rats.
SB-206553 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors.
SB-242084 is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor.
SB-243213 is a research chemical which acts as a selective inverse agonist for the 5HT2C receptor and has anxiolytic effects.
SDZ SER-082 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI).
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.
Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs.
SNORD115 (also known as HBII-52) is a non-coding RNA (ncRNA) molecule known as a small nucleolar RNA which usually functions in guiding the modification of other non-coding RNAs.
The striatum, or corpus striatum (also called the neostriatum and the striate nucleus) is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain.
The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement.
Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents.
The subthalamic nucleus is a small lens-shaped nucleus in the brain where it is, from a functional point of view, part of the basal ganglia system.
The sympathetic nervous system (SNS) is one of the two main divisions of the autonomic nervous system, the other being the parasympathetic nervous system.
In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target efferent cell.
Tedatioxetine (Lu AA24530) is an antidepressant that was discovered by scientists at Lundbeck; in 2007 Lundbeck and Takeda entered into a partnership that included tedatioxetine but was focused on another, more advanced Lundbeck drug candidate, vortioxetine.
Tetracyclic antidepressants (TeCAs) are a class of antidepressants that were first introduced starting in the 1970s.
Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis.
Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates.
Tramadol, sold under the brand name Ultram among others, is an opioid pain medication used to treat moderate to moderately severe pain.
Trazodone, sold under many brand names worldwide, Page accessed Feb 10, 2016 is an antidepressant medication.
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the piperazine chemical class.
Tryptamine is a monoamine alkaloid.
Typical antipsychotics are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia).
In molecular genetics, an untranslated region (or UTR) refers to either of two sections, one on each side of a coding sequence on a strand of mRNA.
Vabicaserin (codenamed SCA-136) was a novel antipsychotic and anorectic under development by Wyeth.
Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP.
Venlafaxine, sold under the brand name Effexor among others, is an antidepressant of the selective serotonin-norepinephrine reuptake inhibitor (SNRI) class.
The ventricular system is a set of four interconnected cavities (ventricles) in the brain, where the cerebrospinal fluid (CSF) is produced.
WAY-161503 is a full agonist of 5-HT2C receptors (Ki.
WAY-629 is a 5-HT2C agonist that reduces feeding behavior when administered to rats.
YM-348 is an indazole derivative drug which acts as a potent and selective 5-HT2C receptor agonist, with an EC50 of 1nM and 15x selectivity over 5-HT2A, although it only has moderate selectivity of 3x over the closely related 5-HT2B receptor.
Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic which is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder.
2,5-Dimethoxy-4-iodoamphetamine (DOI) is a psychedelic drug and a substituted amphetamine.
2,5-Dimethoxy-4-methylamphetamine (DOM; known on the street as STP, standing for "Serenity, Tranquility and Peace") is a psychedelic and a substituted amphetamine.
2C-B or 2,5-dimethoxy-4-bromophenethylamine is a psychedelic drug of the 2C family.
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is a psychedelic of the tryptamine class.
6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide (CEPC) is a drug which acts as a potent and selective antagonist for the serotonin 5-HT2C receptor.