Table of Contents
157 relations: Adverse drug reaction, Air medical services, Allele, Alosetron, Amine, Amino acid, Anatomical Therapeutic Chemical Classification System, Antagonist, Antiemetic, Antihistamine, Antipsychotic, Aprepitant, Aromaticity, Arrhythmia, ATC code A04, Atom, Atypical antipsychotic, Benzimidazole, Biological half-life, Blinded experiment, British Journal of Pharmacology, Byte, Carbazole, Carbon, Carbonyl group, Carbonyl reductase (NADPH), Cell (biology), Central nervous system, Chemical structure, Chemoreceptor trigger zone, Chemotherapy, Chemotherapy-induced nausea and vomiting, Cilansetron, Cisapride, Cisplatin, Clinical trial, Cocaine, Constipation, Coplanarity, Cyclizine, CYP1A1, CYP1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5, Cytochrome P450, Dexamethasone, Diarrhea, ... Expand index (107 more) »
- 5-HT3 antagonists
Adverse drug reaction
An adverse drug reaction (ADR) is a harmful, unintended result caused by taking medication.
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Air medical services
Air medical services are the use of aircraft, including both fixed-wing aircraft and helicopters to provide various kinds of medical care, especially prehospital, emergency and critical care to patients during aeromedical evacuation and rescue operations.
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Allele
An allele, or allelomorph, is a variant of the sequence of nucleotides at a particular location, or locus, on a DNA molecule.
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Alosetron
Alosetron, sold under the brand name Lotronex among others, is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in females only. 5-HT3 antagonist and Alosetron are 5-HT3 antagonists.
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Amine
In chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.
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Amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups.
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Anatomical Therapeutic Chemical Classification System
The Anatomical Therapeutic Chemical (ATC) Classification System is a drug classification system that classifies the active ingredients of drugs according to the organ or system on which they act and their therapeutic, pharmacological and chemical properties.
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Antagonist
An antagonist is a character in a story who is presented as the main enemy and rival of the protagonist.
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Antiemetic
An antiemetic is a drug that is effective against vomiting and nausea. 5-HT3 antagonist and antiemetic are antiemetics.
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Antihistamine
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies.
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Antipsychotic
Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders.
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Aprepitant
Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting and to prevent postoperative nausea and vomiting. 5-HT3 antagonist and Aprepitant are antiemetics.
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Aromaticity
In organic chemistry, aromaticity is a chemical property describing the way in which a conjugated ring of unsaturated bonds, lone pairs, or empty orbitals exhibits a stabilization stronger than would be expected by the stabilization of conjugation alone.
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Arrhythmia
Arrhythmias, also known as cardiac arrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow.
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ATC code A04
A04.
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Atom
Atoms are the basic particles of the chemical elements.
Atypical antipsychotic
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric conditions.
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Benzimidazole
Benzimidazole is a heterocyclic aromatic organic compound.
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Biological half-life
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.
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Blinded experiment
In a blind or blinded experiment, information which may influence the participants of the experiment is withheld until after the experiment is complete.
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British Journal of Pharmacology
The British Journal of Pharmacology is a biweekly peer-reviewed medical journal covering all aspects of experimental pharmacology.
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Byte
The byte is a unit of digital information that most commonly consists of eight bits.
Carbazole
Carbazole is an aromatic heterocyclic organic compound.
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Carbon
Carbon is a chemical element; it has symbol C and atomic number 6.
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Carbonyl group
For organic chemistry, a carbonyl group is a functional group with the formula, composed of a carbon atom double-bonded to an oxygen atom, and it is divalent at the C atom.
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Carbonyl reductase (NADPH)
In enzymology, a carbonyl reductase (NADPH) is an enzyme that catalyzes the chemical reaction R-CO-R' + NADPH + H+ \rightleftharpoons:R-CHOH-R' + NADP+ Thus, the two products of this enzyme are R-CHOH-R' and NADP+, whereas its 3 substrates are R-CO-R', NADPH, and H+.
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Cell (biology)
The cell is the basic structural and functional unit of all forms of life.
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.
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Chemical structure
A chemical structure of a molecule is a spatial arrangement of its atoms and their chemical bonds.
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Chemoreceptor trigger zone
The chemoreceptor trigger zone (CTZ) is an area of the medulla oblongata that receives inputs from blood-borne drugs or hormones, and communicates with other structures in the vomiting center to initiate vomiting.
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Chemotherapy
Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen.
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Chemotherapy-induced nausea and vomiting
Chemotherapy-induced nausea and vomiting (CINV) is a common side-effect of many cancer treatments.
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Cilansetron
Cilansetron is an experimental drug that is a 5-HT3 antagonist under development by Solvay Pharmaceuticals. 5-HT3 antagonist and Cilansetron are 5-HT3 antagonists.
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Cisapride
Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract.
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Cisplatin
Cisplatin is a chemical compound with formula cis-.
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Clinical trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison.
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Cocaine
Cocaine (from, from, ultimately from Quechua: kúka) is a tropane alkaloid that acts as a central nervous system (CNS) stimulant.
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Constipation
Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass.
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Coplanarity
In geometry, a set of points in space are coplanar if there exists a geometric plane that contains them all.
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Cyclizine
Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. 5-HT3 antagonist and Cyclizine are antiemetics.
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CYP1A1
Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene.
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CYP1A2
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body.
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CYP2B6
Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene.
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CYP2C19
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene.
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CYP3A5
Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene.
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Cytochrome P450
Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases.
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Dexamethasone
Dexamethasone is a fluorinated glucocorticoid medication used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, superior vena cava syndrome (a complication of some forms of cancer), and along with antibiotics in tuberculosis.
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Diarrhea
Diarrhea (American English), also spelled diarrhoea or diarrhœa (British English), is the condition of having at least three loose, liquid, or watery bowel movements in a day.
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Dizziness
Dizziness is an imprecise term that can refer to a sense of disorientation in space, vertigo, or lightheadedness.
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Dolasetron
Dolasetron (trade name Anzemet) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. 5-HT3 antagonist and Dolasetron are 5-HT3 antagonists and antiemetics.
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Dopamine receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).
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Dose (biochemistry)
A dose is a measured quantity of a medicine, nutrient, or pathogen which is delivered as a unit.
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Drug class
A drug class is a group of medications and other compounds that have similar chemical structures, the same mechanism of action (i.e. binding to the same biological target), similar modes of action, and/or are used to treat the similar diseases.
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Electrocardiography
Electrocardiography is the process of producing an electrocardiogram (ECG or EKG), a recording of the heart's electrical activity through repeated cardiac cycles.
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Electron
The electron (or in nuclear reactions) is a subatomic particle with a negative one elementary electric charge.
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Enterochromaffin cell
Enterochromaffin (EC) cells (also known as Kulchitsky cells) are a type of enteroendocrine cell, and neuroendocrine cell.
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Enzyme
Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.
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Enzyme induction and inhibition
Enzyme induction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme.
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Enzyme inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.
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Extrapyramidal symptoms
Extrapyramidal symptoms (EPS) are symptoms that are archetypically associated with the extrapyramidal system of the brain's cerebral cortex.
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Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.
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Galanolactone
Galanolactone is a diterpenoid lactone first isolated from ginger.
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Gastrointestinal tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.
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Gastroparesis
Gastroparesis (gastro- from Ancient Greek – gaster, "stomach"; and -paresis, πάρεσις – "partial paralysis"), also called delayed gastric emptying, is a medical disorder consisting of weak muscular contractions (peristalsis) of the stomach, resulting in food and liquid remaining in the stomach for a prolonged period of time.
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Generic drug
A generic drug (or simply generic) is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents.
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Ginger
Ginger (Zingiber officinale) is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine.
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Glucocorticoid
Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones.
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Granisetron
Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy and radiotherapy. 5-HT3 antagonist and Granisetron are 5-HT3 antagonists and antiemetics.
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GSK plc
GSK plc (an acronym from its former name GlaxoSmithKline plc) is a British multinational pharmaceutical and biotechnology company with global headquarters in London.
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Haloperidol
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. 5-HT3 antagonist and Haloperidol are antiemetics.
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Headache
Headache, also known as cephalalgia, is the symptom of pain in the face, head, or neck.
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Heterocyclic compound
A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of its ring(s).
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Histamine receptor
The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.
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Human
Humans (Homo sapiens, meaning "thinking man") or modern humans are the most common and widespread species of primate, and the last surviving species of the genus Homo.
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Hydrogen bond
In chemistry, a hydrogen bond (or H-bond) is primarily an electrostatic force of attraction between a hydrogen (H) atom which is covalently bonded to a more electronegative "donor" atom or group (Dn), and another electronegative atom bearing a lone pair of electrons—the hydrogen bond acceptor (Ac).
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Hydrophobe
In chemistry, hydrophobicity is the physical property of a molecule that is seemingly repelled from a mass of water (known as a hydrophobe).
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Indazole
Indazole, also called isoindazole, is a heterocyclic aromatic organic compound.
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Indole
Indole is an organic compound with the formula.
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Intravenous therapy
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.
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Intrinsic and extrinsic properties
In science and engineering, an intrinsic property is a property of a specified subject that exists itself or within the subject.
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Irritable bowel syndrome
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating and changes in the consistency of bowel movements.
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Ischemic colitis
Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and injury of the large intestine result from inadequate blood supply (ischemia).
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Isoquinoline
Isoquinoline is an individual chemical specimen - a heterocyclic aromatic organic compound - as well as the name of a family of many thousands of natural plant alkaloids, any one of which might be referred to as "an isoquinoline".
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Isozyme
In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.
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Ligand-gated ion channel
Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
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Lipophilicity
Lipophilicity (from Greek λίπος "fat" and φίλος "friendly") is the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.
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Liver
The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.
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McGraw Hill Education
McGraw Hill is an American publishing company for educational content, software, and services for pre-K through postgraduate education.
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Mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.
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Medication
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
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Medscape
Medscape is a website providing access to medical information for clinicians and medical scientists; the organization also provides continuing education for physicians and other health professionals.
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Metabolism
Metabolism (from μεταβολή metabolÄ“, "change") is the set of life-sustaining chemical reactions in organisms.
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Methyl group
In organic chemistry, a methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms, having chemical formula (whereas normal methane has the formula). In formulas, the group is often abbreviated as Me.
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Metoclopramide
Metoclopramide is a medication used for stomach and esophageal problems. 5-HT3 antagonist and Metoclopramide are 5-HT3 antagonists and antiemetics.
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Mirtazapine
Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression. 5-HT3 antagonist and Mirtazapine are antiemetics.
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Morphine
Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum).
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Motion sickness
Motion sickness occurs due to a difference between actual and expected motion.
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Mucous membrane
A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs.
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Muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.
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Nausea
Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit.
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Nitrogen
Nitrogen is a chemical element; it has symbol N and atomic number 7.
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NK1 receptor antagonist
Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties.
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Olanzapine
Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder.
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Ondansetron
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, migraines or surgery. 5-HT3 antagonist and Ondansetron are 5-HT3 antagonists and antiemetics.
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Open-label trial
An open-label trial, or open trial, is a type of clinical trial in which information is not withheld from trial participants.
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Oregon State University
Oregon State University (OSU) is a public land-grant research university based in Corvallis, Oregon.
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Palonosetron
Palonosetron, sold under the brand name Aloxi, is a medication used for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). 5-HT3 antagonist and Palonosetron are 5-HT3 antagonists.
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Pharmacology
Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology.
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Pharmacophore
An example of a pharmacophore model In medicinal chemistry and molecular biology, a pharmacophore is an abstract description of molecular features that are necessary for molecular recognition of a ligand by a biological macromolecule.
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Phenothiazine
Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds.
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Phenoxybenzamine
Phenoxybenzamine (PBZ, marketed under the trade names Dibenzyline and Dibenyline) is a non-selective, irreversible alpha blocker.
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Postoperative nausea and vomiting
Postoperative nausea and vomiting (PONV) is the phenomenon of nausea, vomiting, or retching experienced by a patient in the post-anesthesia care unit (PACU) or within 24 hours following a surgical procedure.
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Potency (pharmacology)
In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.
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Prochlorperazine
Prochlorperazine, formerly sold under the brand name Compazine among others, is a medication used to treat nausea, migraines, schizophrenia, psychosis and anxiety. 5-HT3 antagonist and Prochlorperazine are antiemetics.
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Prodrug
A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
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Prokinetic agent
A prokinetic agent (also prokineticin, gastroprokinetic agent, gastrokinetic agent or propulsive) is a type of small peptide drug which enhances gastrointestinal motility by increasing the frequency or strength of contractions, but without disrupting their rhythm.
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Racemic mixture
In chemistry, a racemic mixture or racemate is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule or salt.
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Radiation therapy
Radiation therapy or radiotherapy (RT, RTx, or XRT) is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells.
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Ramosetron
Ramosetron (INN) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. 5-HT3 antagonist and Ramosetron are 5-HT3 antagonists and antiemetics.
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Randomized controlled trial
A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control.
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Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Renzapride
Renzapride is a prokinetic agent and antiemetic which acts as a full 5-HT4 agonist and partial 5-HT3 antagonist. 5-HT3 antagonist and Renzapride are 5-HT3 antagonists.
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Rodent
Rodents (from Latin rodere, 'to gnaw') are mammals of the order Rodentia, which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws.
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Sandoz
Sandoz Group AG is a Swiss company that focuses on generic pharmaceuticals and biosimilars.
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Schizophrenia
Schizophrenia is a mental disorder characterized by reoccurring episodes of psychosis that are correlated with a general misperception of reality.
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Schizophrenia Research
Schizophrenia Research is a peer-reviewed medical journal covering research on the cause, clinical diagnostics, and treatment of schizophrenia.
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Sedation
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.
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Sensory nerve
A sensory nerve, or afferent nerve, is an anatomic term for a nerve that contains exclusively afferent nerve fibers.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Skeletal formula
The skeletal formula, line-angle formula, bond-line formula or shorthand formula of an organic compound is a type of molecular structural formula that serves as a shorthand representation of a molecule's bonding and some details of its molecular geometry.
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Small intestine
The small intestine or small bowel is an organ in the gastrointestinal tract where most of the absorption of nutrients from food takes place.
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Solitary nucleus
The solitary nucleus (also called nucleus of the solitary tract, nucleus solitarius, or nucleus tractus solitarii (SN or NTS)) is a series of sensory nuclei (clusters of nerve cell bodies) forming a vertical column of grey matter in the medulla oblongata of the brainstem.
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Solvay S.A.
Solvay is a Belgian multinational chemical company established in 1863, with its headquarters located in Neder-Over-Heembeek, Brussels, Belgium.
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Southeast Asia
Southeast Asia is the geographical southeastern region of Asia, consisting of the regions that are situated south of China, east of the Indian subcontinent, and northwest of the Australian mainland, which is part of Oceania.
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Statistical significance
In statistical hypothesis testing, a result has statistical significance when a result at least as "extreme" would be very infrequent if the null hypothesis were true.
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Stereocenter
In stereochemistry, a stereocenter of a molecule is an atom (center), axis or plane that is the focus of stereoisomerism; that is, when having at least three different groups bound to the stereocenter, interchanging any two different groups creates a new stereoisomer.
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Stereochemistry
Stereochemistry, a subdiscipline of chemistry, involves the study of the relative spatial arrangement of atoms that form the structure of molecules and their manipulation.
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Stereoisomerism
In stereochemistry, stereoisomerism, or spatial isomerism, is a form of isomerism in which molecules have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space.
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Structure–activity relationship
The structure–activity relationship (SAR) is the relationship between the chemical structure of a molecule and its biological activity.
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Tardive dyskinesia
Tardive dyskinesia (TD) is a disorder that results in involuntary repetitive body movements, which may include grimacing, sticking out the tongue or smacking the lips.
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Terpenoid
The terpenoids, also known as isoprenoids, are a class of naturally occurring organic chemicals derived from the 5-carbon compound isoprene and its derivatives called terpenes, diterpenes, etc.
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Therapy
A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis.
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Tropisetron
Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia. 5-HT3 antagonist and Tropisetron are 5-HT3 antagonists and antiemetics.
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Tryptophan
Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins.
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University of Colorado Denver
The University of Colorado Denver (CU Denver) is a public research university located in downtown Denver, Colorado.
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University of Edinburgh
The University of Edinburgh (University o Edinburgh, Oilthigh Dhùn Èideann; abbreviated as Edin. in post-nominals) is a public research university based in Edinburgh, Scotland.
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Vagus nerve
The vagus nerve, also known as the tenth cranial nerve, cranial nerve X, or simply CN X, is a cranial nerve that carries sensory fibers that create a pathway that interfaces with the parasympathetic control of the heart, lungs, and digestive tract.
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Vomiting
Vomiting (also known as emesis and throwing up) is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose.
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Vortioxetine
Vortioxetine, sold under the brand name Brintellix among others, is an antidepressant of the serotonin modulator and stimulator (SMS) class. 5-HT3 antagonist and Vortioxetine are 5-HT3 antagonists.
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World Health Organization
The World Health Organization (WHO) is a specialized agency of the United Nations responsible for international public health.
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5-HT receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
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5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors.
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5-HT4 receptor
5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.
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See also
5-HT3 antagonists
- 5-HT3 antagonist
- AS-8112
- Alosetron
- Anpirtoline
- Azasetron
- Batanopride
- Bemesetron
- Bupropion
- Cilansetron
- Dazopride
- Dolasetron
- Fluoxetine
- Gingerol
- Granisetron
- Hydroxybupropion
- Lerisetron
- Litoxetine
- Lurosetron
- Memantine
- Metoclopramide
- Nitrous oxide
- Ondansetron
- Palonosetron
- Ramosetron
- Renzapride
- Ricasetron
- Sevoflurane
- Thujone
- Tropanserin
- Tropisetron
- Vortioxetine
- Xenon
- Zacopride
- Zatosetron
References
Also known as 5-HT3 antagonists, 5-HT3 receptor antagonist, 5-HT3 receptor antagonist:drug discovery and development, 5-hydroxytryptamine 3 receptor antagonist, 5HT-3 antagonist, Discovery and development of serotonin receptor antagonists, Setron, Type 3 serotonin receptor antagonist.