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5-HT4 receptor

Index 5-HT4 receptor

5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. [1]

Table of Contents

  1. 49 relations: Adrenal gland, Animal models of depression, BIMU8, Bladder, Capeserod, Caudate nucleus, Central nervous system, Cisapride, CJ-033466, Cyclic adenosine monophosphate, G protein-coupled receptor, Gastrointestinal tract, Gene, Globus pallidus, GR-113808, Heart, Isotopes of carbon, Lysine, Metoclopramide, Mosapride, Neocortex, Neurotransmitter, Nucleus accumbens, Piboserod, Pontine nuclei, Positron emission tomography, Protein, Prucalopride, Putamen, Radioligand, Raphe nuclei, Renzapride, RS-67,333, SB-204070, Serotonin, Substantia nigra, Sulpiride, Tegaserod, Thalamus, Tropisetron, University of Copenhagen, Zacopride, 5-HT receptor, 5-HT1 receptor, 5-HT2 receptor, 5-HT3 receptor, 5-HT5A receptor, 5-HT6 receptor, 5-HT7 receptor.

  2. Serotonin receptors

Adrenal gland

The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.

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Animal models of depression

Animal models of depression are research tools used to investigate depression and action of antidepressants as a simulation to investigate the symptomatology and pathophysiology of depressive illness or used to screen novel antidepressants.

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BIMU8

BIMU-8 is a drug which acts as a 5-HT4 receptor selective agonist.

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Bladder

The bladder is a hollow organ in humans and other vertebrates that stores urine from the kidneys before disposal by urination.

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Capeserod

Capeserod (INN; development code SL65.0155) is a selective 5-HT4 receptor partial agonist with Ki.

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Caudate nucleus

The caudate nucleus is one of the structures that make up the corpus striatum, which is a component of the basal ganglia in the human brain.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.

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Cisapride

Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract.

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CJ-033466

CJ-033466 is a drug which acts as a potent and selective 5-HT4 serotonin receptor partial agonist.

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Cyclic adenosine monophosphate

Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes.

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G protein-coupled receptor

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses.

See 5-HT4 receptor and G protein-coupled receptor

Gastrointestinal tract

The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.

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Gene

In biology, the word gene has two meanings.

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Globus pallidus

The globus pallidus (GP), also known as paleostriatum or dorsal pallidum, is a subcortical structure of the brain.

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GR-113808

GR-113808 is a drug which acts as a potent and selective 5-HT4 serotonin receptor antagonist.

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Heart

The heart is a muscular organ found in most animals.

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Isotopes of carbon

Carbon (6C) has 14 known isotopes, from to as well as, of which and are stable.

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Lysine

Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins.

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Metoclopramide

Metoclopramide is a medication used for stomach and esophageal problems.

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Mosapride

Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.

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Neocortex

The neocortex, also called the neopallium, isocortex, or the six-layered cortex, is a set of layers of the mammalian cerebral cortex involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language.

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Neurotransmitter

A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.

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Nucleus accumbens

The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the nucleus accumbens septi, Latin for 'nucleus adjacent to the septum') is a region in the basal forebrain rostral to the preoptic area of the hypothalamus.

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Piboserod

Piboserod is a selective 5-HT4 receptor antagonist which was marketed and manufactured by GlaxoSmithKline (GSK) under the trade name Serlipet for the management of atrial fibrillation and irritable bowel syndrome.

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Pontine nuclei

The pontine nuclei (or griseum pontis) are all neurons of the ventral pons collectively.

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Positron emission tomography

Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption.

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Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.

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Prucalopride

Prucalopride, sold under brand names Resolor and Motegrity among others, is a medication acting as a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalizing bowel movements.

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Putamen

The putamen (from Latin, meaning "nutshell") is a round structure located at the base of the forebrain (telencephalon).

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Radioligand

A radioligand is a microscopic particle which consists of a therapeutic radioactive isotope and the cell-targeting compound - the ligand.

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Raphe nuclei

The raphe nuclei (ῥαφή, "seam") are a moderate-size cluster of nuclei found in the brain stem.

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Renzapride

Renzapride is a prokinetic agent and antiemetic which acts as a full 5-HT4 agonist and partial 5-HT3 antagonist.

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RS-67,333

RS-67,333 is a drug which has been investigated as a potential rapid-acting antidepressant, nootropic, and treatment for Alzheimer's disease.

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SB-204070

SB-204070 is a drug which acts as a potent and selective 5-HT4 serotonin receptor antagonist (or weak partial agonist), and is used for research into the function of this receptor subtype.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Substantia nigra

The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement.

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Sulpiride

Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic) medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and is sometimes used in low dosage to treat anxiety and mild depression.

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Tegaserod

Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the names Zelnorm and Zelmac for the management of irritable bowel syndrome and constipation.

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Thalamus

The thalamus (thalami; from Greek θάλαμος, "chamber") is a large mass of gray matter on the lateral walls of the third ventricle forming the dorsal part of the diencephalon (a division of the forebrain).

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Tropisetron

Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia.

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University of Copenhagen

The University of Copenhagen (Københavns Universitet, KU) is a public research university in Copenhagen, Denmark.

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Zacopride

Zacopride is a potent antagonist at the 5-HT3 receptor and an agonist at the 5-HT4 receptor.

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5-HT receptor

5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. 5-HT4 receptor and 5-HT receptor are serotonin receptors.

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5-HT1 receptor

The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). 5-HT4 receptor and 5-HT1 receptor are serotonin receptors.

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5-HT2 receptor

The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT4 receptor and 5-HT2 receptor are serotonin receptors.

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5-HT3 receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. 5-HT4 receptor and 5-HT3 receptor are serotonin receptors.

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5-HT5A receptor

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene. 5-HT4 receptor and 5-HT5A receptor are serotonin receptors.

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5-HT6 receptor

The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT). 5-HT4 receptor and 5-HT6 receptor are serotonin receptors.

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5-HT7 receptor

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT4 receptor and 5-HT7 receptor are serotonin receptors.

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See also

Serotonin receptors

References

[1] https://en.wikipedia.org/wiki/5-HT4_receptor

Also known as 5-HT4, 5-HT4L, 5-HT4L receptor, 5HT4 gene, 5HT4 receptor, HTR4, HTR4 (gene).