18 relations: Astellas Pharma, G protein, Gene, Latrepirdine, Protein, Risperidone, SB-699551, Serotonin, Valerenic acid, Valerian (herb), 5-Carboxamidotryptamine, 5-HT receptor, 5-HT1 receptor, 5-HT2 receptor, 5-HT3 receptor, 5-HT4 receptor, 5-HT6 receptor, 5-HT7 receptor.
is a Japanese pharmaceutical company, formed on 1 April 2005 from the merger of and.
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
Latrepirdine (INN, also known as dimebolin and sold as Dimebon), is an antihistamine drug which has been used clinically in Russia since 1983.
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
SB-699551 is a drug which was the first compound developed to act as a selective antagonist for the serotonin receptor 5-HT5A, with selectivity of around 100x over other serotonin receptor subtypes.
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
Valerenic acid is a sesquiterpenoid constituent of the essential oil of the Valerian plant.
Valerian (Valeriana officinalis, Caprifoliaceae) is a perennial flowering plant native to Europe and Asia.
5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.
5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT).
The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.
The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).
The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.