5-HT5A receptor

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene. ^[1]

26 relations: Agonist, Astellas Pharma, Atypical antipsychotic, Bryan Roth, G protein, Gene, Latrepirdine, Lisuride, LSD, Methylergometrine, Olanzapine, Protein, Receptor antagonist, Risperidone, SB-699551, Serotonin, Valerenic acid, Valerian (herb), 5-Carboxamidotryptamine, 5-HT receptor, 5-HT1 receptor, 5-HT2 receptor, 5-HT3 receptor, 5-HT4 receptor, 5-HT6 receptor, 5-HT7 receptor.
Serotonin receptors

Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

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Astellas Pharma

is a Japanese multinational pharmaceutical company, formed on 1 April 2005 from the merger of and.

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The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric conditions.

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Bryan Roth

Bryan L. Roth is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, UNC School of Medicine.

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G protein

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

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Gene

In biology, the word gene has two meanings.

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Latrepirdine

Latrepirdine (INN, also known as dimebolin and sold as Dimebon) is an antihistamine drug which has been used clinically in Russia since 1983.

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Lisuride

Lisuride, sold under the brand name Dopergin among others, is a monoaminergic medication of the ergoline class which is used in the treatment of Parkinson's disease, migraine, and high prolactin levels.

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LSD

Lysergic acid diethylamide, commonly known as LSD (from German Lysergsäure-diethylamid), and known colloquially as acid or lucy, is a potent psychedelic drug.

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Methylergometrine

Methylergometrine, also known as methylergonovine and sold under the brand name Methergine, is a medication of the ergoline and lysergamide groups which is used as an oxytocic in obstetrics and in the treatment of migraine.

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Olanzapine

Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder.

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Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Risperidone

Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.

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SB-699551

SB-699551 is a drug which was the first compound developed to act as a selective antagonist for the serotonin receptor 5-HT5A, with selectivity of around 100x over other serotonin receptor subtypes.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Valerenic acid

Valerenic acid is a sesquiterpenoid constituent of the essential oil of the valerian plant.

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Valerian (herb)

Valerian (Valeriana officinalis, Caprifoliaceae) is a perennial flowering plant native to Europe and Asia.

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5-Carboxamidotryptamine

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.

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5-HT receptor

5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. 5-HT5A receptor and 5-HT receptor are serotonin receptors.

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5-HT1 receptor

The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). 5-HT5A receptor and 5-HT1 receptor are serotonin receptors.

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5-HT2 receptor

The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT5A receptor and 5-HT2 receptor are serotonin receptors.

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5-HT3 receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. 5-HT5A receptor and 5-HT3 receptor are serotonin receptors.

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5-HT4 receptor

5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. 5-HT5A receptor and 5-HT4 receptor are serotonin receptors.

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5-HT6 receptor

The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT). 5-HT5A receptor and 5-HT6 receptor are serotonin receptors.

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5-HT7 receptor

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT5A receptor and 5-HT7 receptor are serotonin receptors.

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References

[1] https://en.wikipedia.org/wiki/5-HT5A_receptor

Also known as 5-HT5, 5-HT5 receptor, 5-HT5A, HTR5A, HTR5A (gene).

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