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5-HT6 receptor

Index 5-HT6 receptor

The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT). [1]

80 relations: Alzheimer's disease, Antagonist, Antidepressant, Anxiety, Appetite, Asenapine, Atypical antipsychotic, AVN-211, Brain, Caudate nucleus, Cerebellum, Cerebral cortex, Cerlapirdine, Cholinergic, Clozapine, Cognition, Dementia, Dopamine, E-6801, E-6837, EGIS-12,233, EMD-386088, EMDT, Emotionality, Endogeny (biology), Entorhinal cortex, Excitatory postsynaptic potential, Extrapyramidal system, Frontal lobe, G protein–coupled receptor, GABAergic, Gene, Glutamatergic, Gs alpha subunit, Hippocampus, Human, Idalopirdine, Intepirdine, Latrepirdine, Limbic system, Lysergic acid diethylamide, Major depressive disorder, Memory, Mental disorder, Motor control, MS-245, Neurotransmission, Neurotransmitter, Norepinephrine, Nucleus accumbens, ..., Obesity, Obsessive–compulsive disorder, Olanzapine, Olfactory tubercle, Parkinson's disease, Polymorphism (biology), PRX-07034, Receptor (biochemistry), Ro 04-6790, Rosa rugosa, Rs1805054, SB-258585, SB-271046, SB-357134, SB-399885, Selective serotonin reuptake inhibitor, Serotonergic, Serotonin, Sertindole, Striatum, Tricyclic antidepressant, WAY-181187, WAY-208466, Weight loss, 5-HT receptor, 5-HT1 receptor, 5-HT2 receptor, 5-HT3 receptor, 5-HT4 receptor, 5-HT5A receptor. Expand index (30 more) »

Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Antagonist

An antagonist is a character, group of characters, institution or concept that stands in or represents opposition against which the protagonist(s) must contend.

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Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Anxiety

Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.

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Appetite

Appetite is the desire to eat food, sometimes due to hunger.

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Asenapine

Asenapine, sold under the trade names Saphris and Sycrest among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder.

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Atypical antipsychotic

The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.

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AVN-211

AVN-211 (CD-008-0173) is a drug which acts as a highly selective 5-HT6 receptor antagonist and is under development by Avineuro Pharmaceuticals for the treatment of schizophrenia.

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Brain

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

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Caudate nucleus

The caudate nucleus is one of the structures that make up the dorsal striatum, which is a component of the basal ganglia.

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Cerebellum

The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates.

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Cerebral cortex

The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.

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Cerlapirdine

Cerlapirdine (USAN; SAM-531, WAY-262,531, PF-05212365) is a drug which was under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia.

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Cholinergic

In general, the word choline refers to the various quaternary ammonium salts containing the ''N'',''N'',''N''-trimethylethanolammonium cation.

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Clozapine

Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.

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Cognition

Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".

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Dementia

Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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E-6801

E-6801 is a partial agonist of the 5-HT6 receptor.

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E-6837

E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication.

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EGIS-12,233

EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.

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EMD-386088

EMD-386088 is an indole derivative which is used in scientific research.

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EMDT

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT) is a tryptamine derivative which is used in scientific research.

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Emotionality

Emotionality is the observable behavioral and physiological component of emotion.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within an organism, tissue, or cell.

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Entorhinal cortex

The entorhinal cortex (EC) (ento.

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Excitatory postsynaptic potential

In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential.

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Extrapyramidal system

In anatomy, the extrapyramidal system is a part of the motor system network causing involuntary actions.

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Frontal lobe

The frontal lobe, located at the front of the brain, is the largest of the four major lobes of the cerebral cortex in the mammalian brain.

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G protein–coupled receptor

G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.

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GABAergic

GABAergic means "pertaining to or affecting the neurotransmitter GABA".

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Glutamatergic

Glutamatergic means "related to glutamate".

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Gs alpha subunit

The Gs alpha subunit (Gαs, Gsα, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase.

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Hippocampus

The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.

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Human

Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.

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Idalopirdine

Idalopirdine (INN) (code names Lu AE58054) is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia.

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Intepirdine

Intepirdine (INN; developmental codes SB-742457, RVT-101) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.

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Latrepirdine

Latrepirdine (INN, also known as dimebolin and sold as Dimebon), is an antihistamine drug which has been used clinically in Russia since 1983.

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Limbic system

The limbic system is a set of brain structures located on both sides of the thalamus, immediately beneath the cerebrum.

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Lysergic acid diethylamide

Lysergic acid diethylamide (LSD), also known as acid, is a psychedelic drug known for its psychological effects, which may include altered awareness of one's surroundings, perceptions, and feelings as well as sensations and images that seem real though they are not.

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Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

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Memory

Memory is the faculty of the mind by which information is encoded, stored, and retrieved.

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Mental disorder

A mental disorder, also called a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning.

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Motor control

Motor control is the systematic regulation of movement in organisms that possess a nervous system.

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MS-245

MS-245 is a tryptamine derivative which is used in scientific research.

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Neurotransmission

Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

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Nucleus accumbens

The nucleus accumbens (NAc or NAcc), also known as the accumbens nucleus, or formerly as the nucleus accumbens septi (Latin for nucleus adjacent to the septum) is a region in the basal forebrain rostral to the preoptic area of the hypothalamus.

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Obesity

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

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Obsessive–compulsive disorder

Obsessive–compulsive disorder (OCD) is a mental disorder where people feel the need to check things repeatedly, perform certain routines repeatedly (called "rituals"), or have certain thoughts repeatedly (called "obsessions").

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Olanzapine

Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.

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Olfactory tubercle

The olfactory tubercle (OT), also known as the tuberculum olfactorium, is a multi-sensory processing center that is contained within the olfactory cortex and ventral striatum and plays a role in reward cognition.

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Polymorphism (biology)

Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.

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PRX-07034

PRX-07034 is a selective 5-HT6 receptor antagonist.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Ro 04-6790

Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research.

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Rosa rugosa

Rosa rugosa (rugosa rose, beach rose, Japanese rose, or Ramanas rose) is a species of rose native to eastern Asia, in northeastern China, Japan, Korea and southeastern Siberia, where it grows on the coast, often on sand dunes.

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Rs1805054

In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism (SNP), in the HTR6 gene.

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SB-258585

SB-258585 is a drug which is used in scientific research.

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SB-271046

SB-271046 is a drug which is used in scientific research.

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SB-357134

SB-357134 is a drug which is used in scientific research.

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SB-399885

SB-399885 is a drug which is used in scientific research.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

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Serotonergic

Serotonergic or serotoninergic means "pertaining to or affecting serotonin".

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Sertindole

Sertindole (brand names: Serdolect and Serlect) is an antipsychotic medication.

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Striatum

The striatum, or corpus striatum (also called the neostriatum and the striate nucleus) is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain.

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Tricyclic antidepressant

Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.

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WAY-181187

WAY-181187 is a high affinity and selective 5-HT6 receptor full agonist.

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WAY-208466

WAY-208466 is a potent and highly selective full agonist of the 5-HT6 receptor.

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Weight loss

Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose tissue or lean mass, namely bone mineral deposits, muscle, tendon, and other connective tissue.

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5-HT receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.

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5-HT1 receptor

The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT).

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5-HT2 receptor

The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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5-HT3 receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.

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5-HT4 receptor

5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.

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5-HT5A receptor

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.

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Redirects here:

5-HT6, HTR6, HTR6 (gene).

References

[1] https://en.wikipedia.org/wiki/5-HT6_receptor

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