Table of Contents
79 relations: Alzheimer's disease, Antagonist, Antidepressant, Anxiety, Appetite, Asenapine, Atypical antipsychotic, AVN-211, Brain, Caudate nucleus, Cerebellum, Cerebral cortex, Cerlapirdine, Cholinergic, Clozapine, Cognition, Dementia, Dopamine, E-6801, E-6837, EGIS-12,233, EMD-386088, EMDT, Emotionality, Endogeny (biology), Entorhinal cortex, Excitatory postsynaptic potential, Extrapyramidal system, Frontal lobe, G protein-coupled receptor, GABAergic, Gene, Glutamatergic, Gs alpha subunit, Hippocampus, Human, Idalopirdine, Intepirdine, Latrepirdine, Limbic system, LSD, Major depressive disorder, Memory, Mental disorder, Motor control, MS-245, Neurotransmission, Neurotransmitter, Norepinephrine, Nucleus accumbens, ... Expand index (29 more) »
- Serotonin receptors
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens, and is the cause of 60–70% of cases of dementia.
See 5-HT6 receptor and Alzheimer's disease
Antagonist
An antagonist is a character in a story who is presented as the main enemy and rival of the protagonist.
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Antidepressant
Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction.
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Anxiety
Anxiety is an emotion which is characterised by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events.
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Appetite
Appetite is the desire to eat food items, usually due to hunger.
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Asenapine
Asenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder.
See 5-HT6 receptor and Asenapine
Atypical antipsychotic
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric conditions.
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AVN-211
AVN-211 (CD-008-0173) is a drug which acts as a highly selective 5-HT6 receptor antagonist and is under development by Avineuro Pharmaceuticals for the treatment of schizophrenia.
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
Caudate nucleus
The caudate nucleus is one of the structures that make up the corpus striatum, which is a component of the basal ganglia in the human brain.
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Cerebellum
The cerebellum (cerebella or cerebellums; Latin for "little brain") is a major feature of the hindbrain of all vertebrates.
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Cerebral cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals.
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Cerlapirdine
Cerlapirdine (USAN; SAM-531, WAY-262,531, PF-05212365) is a drug which was under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia.
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Cholinergic
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine.
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Clozapine
Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered.
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Cognition
Cognition is the "mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".
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Dementia
Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform everyday activities.
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.
See 5-HT6 receptor and Dopamine
E-6801
E-6801 is a partial agonist of the 5-HT6 receptor.
E-6837
E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication.
EGIS-12,233
EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.
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EMD-386088
EMD-386088 is an indole derivative which is used in scientific research.
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EMDT
2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT) is a tryptamine derivative which is used in scientific research.
Emotionality
Emotionality is the observable behavioral and physiological component of emotion.
See 5-HT6 receptor and Emotionality
Endogeny (biology)
Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.
See 5-HT6 receptor and Endogeny (biology)
Entorhinal cortex
The entorhinal cortex (EC) is an area of the brain's allocortex, located in the medial temporal lobe, whose functions include being a widespread network hub for memory, navigation, and the perception of time.
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Excitatory postsynaptic potential
In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential.
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Extrapyramidal system
In anatomy, the extrapyramidal system is a part of the motor system network causing involuntary actions.
See 5-HT6 receptor and Extrapyramidal system
Frontal lobe
The frontal lobe is the largest of the four major lobes of the brain in mammals, and is located at the front of each cerebral hemisphere (in front of the parietal lobe and the temporal lobe).
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G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses.
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GABAergic
In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA).
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Gene
In biology, the word gene has two meanings.
Glutamatergic
Glutamatergic means "related to glutamate".
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Gs alpha subunit
The Gs alpha subunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase.
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Hippocampus
The hippocampus (hippocampi; via Latin from Greek ἱππόκαμπος, 'seahorse') is a major component of the brain of humans and other vertebrates.
See 5-HT6 receptor and Hippocampus
Human
Humans (Homo sapiens, meaning "thinking man") or modern humans are the most common and widespread species of primate, and the last surviving species of the genus Homo.
Idalopirdine
Idalopirdine (INN) (code names Lu AE58054) is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia.
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Intepirdine
Intepirdine (INN; developmental codes SB-742457, RVT-101) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects.
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Latrepirdine
Latrepirdine (INN, also known as dimebolin and sold as Dimebon) is an antihistamine drug which has been used clinically in Russia since 1983.
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Limbic system
The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain.
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LSD
Lysergic acid diethylamide, commonly known as LSD (from German Lysergsäure-diethylamid), and known colloquially as acid or lucy, is a potent psychedelic drug.
Major depressive disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities.
See 5-HT6 receptor and Major depressive disorder
Memory
Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed.
Mental disorder
A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning.
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Motor control
Motor control is the regulation of movements in organisms that possess a nervous system.
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MS-245
MS-245 is a tryptamine derivative used in scientific research.
Neurotransmission
Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and react with the receptors on the dendrites of another neuron (the postsynaptic neuron) a short distance away.
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Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.
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Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone, neurotransmitter and neuromodulator.
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Nucleus accumbens
The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the nucleus accumbens septi, Latin for 'nucleus adjacent to the septum') is a region in the basal forebrain rostral to the preoptic area of the hypothalamus.
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Obesity
Obesity is a medical condition, sometimes considered a disease, in which excess body fat has accumulated to such an extent that it can potentially have negative effects on health.
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Obsessive–compulsive disorder
Obsessive–compulsive disorder (OCD) is a mental and behavioral disorder in which an individual has intrusive thoughts (an obsession) and feels the need to perform certain routines (compulsions) repeatedly to relieve the distress caused by the obsession, to the extent where it impairs general function.
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Olanzapine
Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder.
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Olfactory tubercle
The olfactory tubercle (OT), also known as the tuberculum olfactorium, is a multi-sensory processing center that is contained within the olfactory cortex and ventral striatum and plays a role in reward cognition.
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Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a long-term neurodegenerative disease of mainly the central nervous system that affects both the motor and non-motor systems of the body.
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Polymorphism (biology)
In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.
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PRX-07034
PRX-07034 is a selective 5-HT6 receptor antagonist.
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Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.
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Ro 04-6790
Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research.
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Rosa rugosa
Rosa rugosa (rugosa rose, beach rose, Japanese rose, Ramanas rose, or letchberry) is a species of rose native to eastern Asia, in northeastern China, Japan, Korea and southeastern Siberia, where it grows on beach coasts, often on sand dunes.
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Rs1805054
In genetics, Rs1805054, also called C267T, is a name used for a specific genetic variation, a single nucleotide polymorphism (SNP), in the HTR6 gene.
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SB-258585
SB-258585 is a drug which is used in scientific research.
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SB-271046
SB-271046 is a drug which is used in scientific research.
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SB-357134
SB-357134 is a drug which is used in scientific research.
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SB-399885
SB-399885 is a drug which is used in scientific research.
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Selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
See 5-HT6 receptor and Selective serotonin reuptake inhibitor
Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
See 5-HT6 receptor and Serotonin
Sertindole
Sertindole, sold under the brand name Serdolect among others, is an antipsychotic medication.
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Striatum
The striatum (striata) or corpus striatum is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia.
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Tricyclic antidepressant
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
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WAY-181187
WAY-181187 is a high affinity and selective 5-HT6 receptor full agonist.
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WAY-208466
WAY-208466 is a potent and highly selective full agonist of the 5-HT6 receptor.
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Weight loss
Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue).
See 5-HT6 receptor and Weight loss
5-HT receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. 5-HT6 receptor and 5-HT receptor are serotonin receptors.
See 5-HT6 receptor and 5-HT receptor
5-HT1 receptor
The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). 5-HT6 receptor and 5-HT1 receptor are serotonin receptors.
See 5-HT6 receptor and 5-HT1 receptor
5-HT2 receptor
The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT6 receptor and 5-HT2 receptor are serotonin receptors.
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5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. 5-HT6 receptor and 5-HT3 receptor are serotonin receptors.
See 5-HT6 receptor and 5-HT3 receptor
5-HT4 receptor
5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. 5-HT6 receptor and 5-HT4 receptor are serotonin receptors.
See 5-HT6 receptor and 5-HT4 receptor
5-HT5A receptor
5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene. 5-HT6 receptor and 5-HT5A receptor are serotonin receptors.
See 5-HT6 receptor and 5-HT5A receptor
See also
Serotonin receptors
- 5-HT receptor
- 5-HT1 receptor
- 5-HT1A receptor
- 5-HT1B receptor
- 5-HT1D receptor
- 5-HT1E receptor
- 5-HT1F receptor
- 5-HT2 receptor
- 5-HT2A receptor
- 5-HT2B receptor
- 5-HT2C receptor
- 5-HT3 receptor
- 5-HT4 receptor
- 5-HT5A receptor
- 5-HT5B receptor
- 5-HT6 receptor
- 5-HT7 receptor
- HTR3A
- HTR3B
- HTR3C
- HTR3D
- HTR3E
References
Also known as 5-HT6, 5-HT6 agonist, 5-HT6 agonists, 5-HT6 antagonist, 5-HT6 antagonists, 5-HT6 receptor agonist, 5-HT6 receptor agonists, 5-HT6 receptor antagonist, 5-HT6 receptor antagonists, 5-hydroxytryptamine subtype 6 receptor, HTR6, HTR6 (gene).