Table of Contents
101 relations: Adenylyl cyclase, AGH-107, AGH-192, Agonist, AH-494, Alternative splicing, Amisulpride, Amitriptyline, Amoxapine, Aripiprazole, AS-19 (drug), AVN-101, Brexpiprazole, Bromocriptine, Bryan Roth, C-terminus, Cerebral cortex, Circadian rhythm, Circulatory system, Clomipramine, Clozapine, Cyclic adenosine monophosphate, DR-4485, E-55888, Efficacy, EGIS-12,233, Fluperlapine, Fluphenazine, Functional selectivity, G protein-coupled receptor, Gastrointestinal tract, Gene, Glossary of biology, Gs alpha subunit, Heterotrimeric G protein, Hippocampus, Hyperalgesia, Hypothalamus, Imipramine, Inverse agonist, Irritable bowel syndrome, JNJ-18038683, Ketanserin, Learning, Lisuride, Loxapine, LP-12, LP-211, LP-44, Lurasidone, ... Expand index (51 more) »
- Serotonin receptors
Adenylyl cyclase
Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming).
See 5-HT7 receptor and Adenylyl cyclase
AGH-107
AGH-107 is a potent, selective, water-soluble and brain penetrant full agonist at the 5HT7 serotonin receptor.
See 5-HT7 receptor and AGH-107
AGH-192
AGH-192 is a potent and selective, water soluble, orally bioavailable and brain penetrant full agonist at the 5HT7 serotonin receptor, derived from the older drug AGH-107.
See 5-HT7 receptor and AGH-192
Agonist
An agonist is a chemical that activates a receptor to produce a biological response.
See 5-HT7 receptor and Agonist
AH-494
AH-494 is a potent and selective, water-soluble full agonist at the 5HT7 serotonin receptor.
Alternative splicing
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to produce different splice variants.
See 5-HT7 receptor and Alternative splicing
Amisulpride
Amisulpride is an antiemetic and antipsychotic medication used at lower doses intravenously to prevent and treat postoperative nausea and vomiting; and at higher doses by mouth to treat schizophrenia and acute psychotic episodes.
See 5-HT7 receptor and Amisulpride
Amitriptyline
Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches.
See 5-HT7 receptor and Amitriptyline
Amoxapine
Amoxapine, sold under the brand name Asendin among others, is a tricyclic antidepressant (TCA).
See 5-HT7 receptor and Amoxapine
Aripiprazole
Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder; other uses include as an add-on treatment in major depressive disorder and obsessive compulsive disorder (OCD), tic disorders, and irritability associated with autism.
See 5-HT7 receptor and Aripiprazole
AS-19 (drug)
AS-19 is a substance which acts as a potent agonist at the 5-HT7 receptor, with an IC50 of 0.83 nM.
See 5-HT7 receptor and AS-19 (drug)
AVN-101
AVN-101, a close structural analogue of latrepirdine, is a selective 5-HT6 receptor antagonist which is under development by Avineuro Pharmaceuticals for the treatment of Alzheimer's disease and anxiety disorders.
See 5-HT7 receptor and AVN-101
Brexpiprazole
Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic medication used for the treatment of major depressive disorder, schizophrenia, and agitation associated with dementia due to Alzheimer's disease.
See 5-HT7 receptor and Brexpiprazole
Bromocriptine
Bromocriptine, originally marketed as Parlodel and subsequently under many brand names, is an ergoline derivative and dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and, as an adjunct, type 2 diabetes.
See 5-HT7 receptor and Bromocriptine
Bryan Roth
Bryan L. Roth is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics, UNC School of Medicine.
See 5-HT7 receptor and Bryan Roth
C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
See 5-HT7 receptor and C-terminus
Cerebral cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals.
See 5-HT7 receptor and Cerebral cortex
Circadian rhythm
A circadian rhythm, or circadian cycle, is a natural oscillation that repeats roughly every 24 hours.
See 5-HT7 receptor and Circadian rhythm
Circulatory system
The circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate.
See 5-HT7 receptor and Circulatory system
Clomipramine
Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).
See 5-HT7 receptor and Clomipramine
Clozapine
Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered.
See 5-HT7 receptor and Clozapine
Cyclic adenosine monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes.
See 5-HT7 receptor and Cyclic adenosine monophosphate
DR-4485
DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT7 receptor, with good oral bioavailability.
See 5-HT7 receptor and DR-4485
E-55888
E-55888 is a drug developed by Esteve, which acts as a potent and selective full agonist at the 5HT7 serotonin receptor, and is used for investigating the role of 5-HT7 receptors in the perception of pain.
See 5-HT7 receptor and E-55888
Efficacy
Efficacy is the ability to perform a task to a satisfactory or expected degree.
See 5-HT7 receptor and Efficacy
EGIS-12,233
EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.
See 5-HT7 receptor and EGIS-12,233
Fluperlapine
Fluperlapine (NB 106-689), also known as fluoroperlapine, is a morphanthridine (11H-dibenzoazepine) atypical antipsychotic with additional antidepressant and sedative effects.
See 5-HT7 receptor and Fluperlapine
Fluphenazine
Fluphenazine, sold under the brand name Prolixin among others, is a high-potency typical antipsychotic medication.
See 5-HT7 receptor and Fluphenazine
Functional selectivity
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signaling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.
See 5-HT7 receptor and Functional selectivity
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses.
See 5-HT7 receptor and G protein-coupled receptor
Gastrointestinal tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.
See 5-HT7 receptor and Gastrointestinal tract
Gene
In biology, the word gene has two meanings.
Glossary of biology
This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms.
See 5-HT7 receptor and Glossary of biology
Gs alpha subunit
The Gs alpha subunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase.
See 5-HT7 receptor and Gs alpha subunit
Heterotrimeric G protein
Heterotrimeric G protein, also sometimes referred to as the "large" G proteins (as opposed to the subclass of smaller, monomeric small GTPases) are membrane-associated G proteins that form a heterotrimeric complex.
See 5-HT7 receptor and Heterotrimeric G protein
Hippocampus
The hippocampus (hippocampi; via Latin from Greek ἱππόκαμπος, 'seahorse') is a major component of the brain of humans and other vertebrates.
See 5-HT7 receptor and Hippocampus
Hyperalgesia
Hyperalgesia (or; 'hyper' from Greek ὑπέρ (huper, “over”), '-algesia' from Greek algos, ἄλγος (pain)) is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus.
See 5-HT7 receptor and Hyperalgesia
Hypothalamus
The hypothalamus (hypothalami) is a small part of the vertebrate brain that contains a number of nuclei with a variety of functions.
See 5-HT7 receptor and Hypothalamus
Imipramine
Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression.
See 5-HT7 receptor and Imipramine
Inverse agonist
In pharmacology, an inverse agonist is a drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist.
See 5-HT7 receptor and Inverse agonist
Irritable bowel syndrome
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating and changes in the consistency of bowel movements.
See 5-HT7 receptor and Irritable bowel syndrome
JNJ-18038683
JNJ-18038683 is a potent and selective antagonist of the 5HT7 serotonin receptor discovered by Johnson & Johnson.
See 5-HT7 receptor and JNJ-18038683
Ketanserin
Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former developmental code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonergic system; specifically, the 5-HT2 receptor family. It was discovered at Janssen Pharmaceutica in 1980. It is not available in the United States.
See 5-HT7 receptor and Ketanserin
Learning
Learning is the process of acquiring new understanding, knowledge, behaviors, skills, values, attitudes, and preferences.
See 5-HT7 receptor and Learning
Lisuride
Lisuride, sold under the brand name Dopergin among others, is a monoaminergic medication of the ergoline class which is used in the treatment of Parkinson's disease, migraine, and high prolactin levels.
See 5-HT7 receptor and Lisuride
Loxapine
Loxapine, sold under the brand names Loxitane and Adasuve (inhalation only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia.
See 5-HT7 receptor and Loxapine
LP-12
LP-12 is a drug which acts as a potent agonist at the 5HT7 serotonin receptor, with very high selectivity over other tested receptor subtypes such as the serotonin 5-HT1A and 5-HT2A, and the dopamine D2 receptor.
LP-211
LP-211 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor, with better brain penetration than older 5-HT7 agonists in the same series, and similar effects in animals.
LP-44
LP-44 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor.
Lurasidone
Lurasidone, sold under the brand name Latuda among others, is an antipsychotic medication used to treat schizophrenia and bipolar disorder.
See 5-HT7 receptor and Lurasidone
LY-215,840
LY-215,840 is an ergoline derivative drug developed by Eli Lilly, which acts as a potent and selective antagonist at the serotonin 5-HT2 and 5-HT7 receptors.
See 5-HT7 receptor and LY-215,840
Major depressive disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities.
See 5-HT7 receptor and Major depressive disorder
Maprotiline
Maprotiline, sold under the brand name Ludiomil among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression.
See 5-HT7 receptor and Maprotiline
Memory
Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed.
Mesulergine
Mesulergine (developmental code name CU-32085) is a drug of the ergoline group which was never marketed.
See 5-HT7 receptor and Mesulergine
Metergoline
Metergoline, also known as methergoline and sold under the brand names Contralac (veterinary) and Liserdol (clinical), is a monoaminergic medication of the ergoline group which is used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) and to suppress lactation.
See 5-HT7 receptor and Metergoline
Methysergide
Methysergide, sold under the brand names Deseril and Sansert, is a monoaminergic medication of the ergoline and lysergamide groups which is used in the prophylaxis and treatment of migraine and cluster headaches.
See 5-HT7 receptor and Methysergide
Metitepine
Metitepine (developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic group which was never marketed.
See 5-HT7 receptor and Metitepine
Mianserin
Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant that is used primarily in the treatment of depression in Europe and elsewhere in the world.
See 5-HT7 receptor and Mianserin
Mood (psychology)
In psychology, a mood is an affective state.
See 5-HT7 receptor and Mood (psychology)
Muscle relaxant
A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.
See 5-HT7 receptor and Muscle relaxant
N,N-Dimethyltryptamine
N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine.
See 5-HT7 receptor and N,N-Dimethyltryptamine
N-Methylserotonin
N-Methylserotonin is a tryptamine alkaloid.
See 5-HT7 receptor and N-Methylserotonin
Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.
See 5-HT7 receptor and Neurotransmitter
Olanzapine
Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder.
See 5-HT7 receptor and Olanzapine
Paliperidone
Paliperidone, sold under the brand name Invega among others, is an atypical antipsychotic.
See 5-HT7 receptor and Paliperidone
Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
See 5-HT7 receptor and Partial agonist
Pimozide
Pimozide (sold under the brand name Orap) is a neuroleptic drug of the diphenylbutylpiperidine class.
See 5-HT7 receptor and Pimozide
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.
See 5-HT7 receptor and Receptor (biochemistry)
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
See 5-HT7 receptor and Receptor antagonist
Risperidone
Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.
See 5-HT7 receptor and Risperidone
Ritanserin
Ritanserin, also known by its developmental code name R-55667, is a serotonin antagonist medication described as an anxiolytic, antidepressant, antiparkinsonian agent, and antihypertensive agent.
See 5-HT7 receptor and Ritanserin
SB-258719
SB-258719 is a drug developed by GlaxoSmithKline which acts as a selective 5-HT7 receptor partial inverse agonist, and was the first such ligand identified for 5-HT7.
See 5-HT7 receptor and SB-258719
SB-269970
SB-269970 is a drug and research chemical developed by GlaxoSmithKline used in scientific studies.
See 5-HT7 receptor and SB-269970
Second messenger system
Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers.
See 5-HT7 receptor and Second messenger system
Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
See 5-HT7 receptor and Serotonin
Sertindole
Sertindole, sold under the brand name Serdolect among others, is an antipsychotic medication.
See 5-HT7 receptor and Sertindole
Sleep
Sleep is a state of reduced mental and physical activity in which consciousness is altered and certain sensory activity is inhibited.
Smooth muscle
Smooth (soft) muscle is one of the three major types of vertebrate muscle tissue, the other being skeletal and cardiac muscle.
See 5-HT7 receptor and Smooth muscle
Spiperone
Spiperone (Spiroperidol; brand name: Spiropitan (JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class.
See 5-HT7 receptor and Spiperone
Tenilapine
Tenilapine is an atypical antipsychotic which has never been marketed in the US.
See 5-HT7 receptor and Tenilapine
Thalamus
The thalamus (thalami; from Greek θάλαμος, "chamber") is a large mass of gray matter on the lateral walls of the third ventricle forming the dorsal part of the diencephalon (a division of the forebrain).
See 5-HT7 receptor and Thalamus
Thermoregulation
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different.
See 5-HT7 receptor and Thermoregulation
Trifluoperazine
Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia.
See 5-HT7 receptor and Trifluoperazine
Trifluoromethylphenylpiperazine
3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the phenylpiperazine chemical class and is a substituted piperazine.
See 5-HT7 receptor and Trifluoromethylphenylpiperazine
Visceral pain
Visceral pain is pain that results from the activation of nociceptors of the thoracic, pelvic, or abdominal viscera (organs).
See 5-HT7 receptor and Visceral pain
Vortioxetine
Vortioxetine, sold under the brand name Brintellix among others, is an antidepressant of the serotonin modulator and stimulator (SMS) class.
See 5-HT7 receptor and Vortioxetine
Ziprasidone
Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder.
See 5-HT7 receptor and Ziprasidone
Zotepine
Zotepine is an atypical antipsychotic drug indicated for acute and chronic schizophrenia.
See 5-HT7 receptor and Zotepine
1-(2-Diphenyl)piperazine
1-(2-Diphenyl)piperazine, also known as RA-7, is a drug which acts as a potent and selective antagonist at the 7 serotonin receptor.
See 5-HT7 receptor and 1-(2-Diphenyl)piperazine
5-Carboxamidotryptamine
5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.
See 5-HT7 receptor and 5-Carboxamidotryptamine
5-HT receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. 5-HT7 receptor and 5-HT receptor are serotonin receptors.
See 5-HT7 receptor and 5-HT receptor
5-HT1 receptor
The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). 5-HT7 receptor and 5-HT1 receptor are serotonin receptors.
See 5-HT7 receptor and 5-HT1 receptor
5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT7 receptor and 5-HT1A receptor are serotonin receptors.
See 5-HT7 receptor and 5-HT1A receptor
5-HT2 receptor
The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor and 5-HT2 receptor are serotonin receptors.
See 5-HT7 receptor and 5-HT2 receptor
5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. 5-HT7 receptor and 5-HT3 receptor are serotonin receptors.
See 5-HT7 receptor and 5-HT3 receptor
5-HT4 receptor
5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene. 5-HT7 receptor and 5-HT4 receptor are serotonin receptors.
See 5-HT7 receptor and 5-HT4 receptor
5-HT5A receptor
5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene. 5-HT7 receptor and 5-HT5A receptor are serotonin receptors.
See 5-HT7 receptor and 5-HT5A receptor
5-HT6 receptor
The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT). 5-HT7 receptor and 5-HT6 receptor are serotonin receptors.
See 5-HT7 receptor and 5-HT6 receptor
5-Methoxytryptamine
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin.
See 5-HT7 receptor and 5-Methoxytryptamine
8-OH-DPAT
8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor.
See 5-HT7 receptor and 8-OH-DPAT
See also
Serotonin receptors
- 5-HT receptor
- 5-HT1 receptor
- 5-HT1A receptor
- 5-HT1B receptor
- 5-HT1D receptor
- 5-HT1E receptor
- 5-HT1F receptor
- 5-HT2 receptor
- 5-HT2A receptor
- 5-HT2B receptor
- 5-HT2C receptor
- 5-HT3 receptor
- 5-HT4 receptor
- 5-HT5A receptor
- 5-HT5B receptor
- 5-HT6 receptor
- 5-HT7 receptor
- HTR3A
- HTR3B
- HTR3C
- HTR3D
- HTR3E
References
Also known as 5-HT7, HTR7, HTR7 (gene).