Logo
Unionpedia
Communication
Get it on Google Play
New! Download Unionpedia on your Android™ device!
Free
Faster access than browser!
 

5-HT7 receptor

Index 5-HT7 receptor

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels. [1]

93 relations: Adenylyl cyclase, AGH-107, Agonist, Alternative splicing, Amisulpride, Amitriptyline, Amoxapine, Aripiprazole, AS-19 (drug), Autism, Bromocriptine, C-terminus, Cerebral cortex, Circadian rhythm, Circulatory system, Clomipramine, Clozapine, Cyclic adenosine monophosphate, DR-4485, E-55888, Efficacy, EGIS-12,233, Fluperlapine, Fluphenazine, G protein–coupled receptor, Gastrointestinal tract, Gene, Gs alpha subunit, Heterotrimeric G protein, Hippocampus, Hypothalamus, Imipramine, Intracellular, Inverse agonist, Ketanserin, Learning, Lisuride, Locus (genetics), Loxapine, LP-12, LP-211, LP-44, Lurasidone, LY-215,840, Major depressive disorder, Maprotiline, Memory, Mesulergine, Metergoline, Methysergide, ..., Metitepine, Mianserin, Molecular binding, Mood (psychology), Muscle relaxant, N,N-Dimethyltryptamine, N-Methylserotonin, Neurotransmitter, Olanzapine, Paliperidone, Partial agonist, Pimozide, Receptor (biochemistry), Receptor antagonist, Risperidone, Ritanserin, SB-258719, SB-269970, Second messenger system, Serotonin, Sertindole, Sleep, Smooth muscle tissue, Spiperone, Thalamus, Thermoregulation, Trifluoperazine, Trifluoromethylphenylpiperazine, Vortioxetine, Ziprasidone, Zotepine, 1-(2-Diphenyl)piperazine, 5-Carboxamidotryptamine, 5-HT receptor, 5-HT1 receptor, 5-HT1A receptor, 5-HT2 receptor, 5-HT3 receptor, 5-HT4 receptor, 5-HT5A receptor, 5-HT6 receptor, 5-Methoxytryptamine, 8-OH-DPAT. Expand index (43 more) »

Adenylyl cyclase

Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.

New!!: 5-HT7 receptor and Adenylyl cyclase · See more »

AGH-107

AGH-107 is a potent and selective, water soluble and brain penetrant full agonist at the 5HT7 serotonin receptor.

New!!: 5-HT7 receptor and AGH-107 · See more »

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

New!!: 5-HT7 receptor and Agonist · See more »

Alternative splicing

Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.

New!!: 5-HT7 receptor and Alternative splicing · See more »

Amisulpride

Amisulpride, sold under the brand name Solian among others, is an antipsychotic medication used to treat schizophrenia.

New!!: 5-HT7 receptor and Amisulpride · See more »

Amitriptyline

Amitriptyline, sold under the brand name Elavil among others, is a medicine primarily used to treat a number of mental illnesses.

New!!: 5-HT7 receptor and Amitriptyline · See more »

Amoxapine

Amoxapine, sold under the brand name Asendin among others, is a tetracyclic antidepressant (TeCA), though it is often classified as a tricyclic antidepressant (TCA).

New!!: 5-HT7 receptor and Amoxapine · See more »

Aripiprazole

Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. According to a Cochrane review, evidence for the oral form in schizophrenia is not sufficient to determine effects on general functioning. Additionally, because many people dropped out of the medication trials before they were completed, the overall strength of the conclusions is low. Side effects include neuroleptic malignant syndrome, a movement disorder known as tardive dyskinesia, and high blood sugar in those with diabetes. In the elderly there is an increased risk of death. It is thus not recommended for use in those with psychosis due to dementia. It is pregnancy category C in the United States and category C in Australia, meaning there is possible evidence of harm to the fetus. It is not recommended for women who are breastfeeding. It is unclear whether it is safe or effective in people less than 18 years old. It is a partial dopamine agonist. Aripiprazole was developed by Otsuka in Japan. In the United States, Otsuka America markets it jointly with Bristol-Myers Squibb. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.

New!!: 5-HT7 receptor and Aripiprazole · See more »

AS-19 (drug)

AS-19 is a substance which acts as a potent agonist at the 5HT7 receptor, with an IC50 of 0.83nM.

New!!: 5-HT7 receptor and AS-19 (drug) · See more »

Autism

Autism is a developmental disorder characterized by troubles with social interaction and communication and by restricted and repetitive behavior.

New!!: 5-HT7 receptor and Autism · See more »

Bromocriptine

Bromocriptine (originally marketed as Parlodel, subsequently under many names) is an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.

New!!: 5-HT7 receptor and Bromocriptine · See more »

C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

New!!: 5-HT7 receptor and C-terminus · See more »

Cerebral cortex

The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.

New!!: 5-HT7 receptor and Cerebral cortex · See more »

Circadian rhythm

A circadian rhythm is any biological process that displays an endogenous, entrainable oscillation of about 24 hours.

New!!: 5-HT7 receptor and Circadian rhythm · See more »

Circulatory system

The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.

New!!: 5-HT7 receptor and Circulatory system · See more »

Clomipramine

Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).

New!!: 5-HT7 receptor and Clomipramine · See more »

Clozapine

Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.

New!!: 5-HT7 receptor and Clozapine · See more »

Cyclic adenosine monophosphate

Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.

New!!: 5-HT7 receptor and Cyclic adenosine monophosphate · See more »

DR-4485

DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT7 receptor, with good oral bioavailability.

New!!: 5-HT7 receptor and DR-4485 · See more »

E-55888

E-55888 is a drug developed by Esteve, which acts as a potent and selective full agonist at the 5HT7 serotonin receptor, and is used for investigating the role of 5-HT7 receptors in the perception of pain.

New!!: 5-HT7 receptor and E-55888 · See more »

Efficacy

Efficacy is the ability to get a job done satisfactorily.

New!!: 5-HT7 receptor and Efficacy · See more »

EGIS-12,233

EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.

New!!: 5-HT7 receptor and EGIS-12,233 · See more »

Fluperlapine

Fluperlapine (NB 106-689), also known as fluoroperlapine, is a morphanthridine (11H-dibenzoazepine) atypical antipsychotic with additional antidepressant and sedative effects.

New!!: 5-HT7 receptor and Fluperlapine · See more »

Fluphenazine

Fluphenazine, sold under the brand names Prolixin among others, is an antipsychotic medication.

New!!: 5-HT7 receptor and Fluphenazine · See more »

G protein–coupled receptor

G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.

New!!: 5-HT7 receptor and G protein–coupled receptor · See more »

Gastrointestinal tract

The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.

New!!: 5-HT7 receptor and Gastrointestinal tract · See more »

Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

New!!: 5-HT7 receptor and Gene · See more »

Gs alpha subunit

The Gs alpha subunit (Gαs, Gsα, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase.

New!!: 5-HT7 receptor and Gs alpha subunit · See more »

Heterotrimeric G protein

"G protein" usually refers to the membrane-associated heterotrimeric G proteins, sometimes referred to as the "large" G proteins (as opposed to the subclass of smaller, monomeric small GTPases).

New!!: 5-HT7 receptor and Heterotrimeric G protein · See more »

Hippocampus

The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.

New!!: 5-HT7 receptor and Hippocampus · See more »

Hypothalamus

The hypothalamus(from Greek ὑπό, "under" and θάλαμος, thalamus) is a portion of the brain that contains a number of small nuclei with a variety of functions.

New!!: 5-HT7 receptor and Hypothalamus · See more »

Imipramine

Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression.

New!!: 5-HT7 receptor and Imipramine · See more »

Intracellular

In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".

New!!: 5-HT7 receptor and Intracellular · See more »

Inverse agonist

In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.

New!!: 5-HT7 receptor and Inverse agonist · See more »

Ketanserin

Ketanserin (INN, USAN, BAN) (brand name Sufrexal; former developmental code name R41468) is a drug used clinically as an antihypertensive agent and in scientific research to study the serotonin system; specifically, the 5-HT2 receptor family.

New!!: 5-HT7 receptor and Ketanserin · See more »

Learning

Learning is the process of acquiring new or modifying existing knowledge, behaviors, skills, values, or preferences.

New!!: 5-HT7 receptor and Learning · See more »

Lisuride

Lisuride, sold under the brand names Dopergin, Proclacam, and Revanil, is an antiparkinson agent of the iso-ergoline class, chemically related to the dopaminergic ergoline Parkinson's drugs.

New!!: 5-HT7 receptor and Lisuride · See more »

Locus (genetics)

A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).

New!!: 5-HT7 receptor and Locus (genetics) · See more »

Loxapine

Loxapine (several trade names worldwide) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia.

New!!: 5-HT7 receptor and Loxapine · See more »

LP-12

LP-12 is a drug which acts as a potent agonist at the 5HT7 serotonin receptor, with very high selectivity over other tested receptor subtypes such as the serotonin 5-HT1A and 5-HT2A, and the dopamine D2 receptor.

New!!: 5-HT7 receptor and LP-12 · See more »

LP-211

LP-211 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor, with better brain penetration than older 5-HT7 agonists in the same series, and similar effects in animals.

New!!: 5-HT7 receptor and LP-211 · See more »

LP-44

LP-44 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor.

New!!: 5-HT7 receptor and LP-44 · See more »

Lurasidone

Lurasidone (trade name Latuda) is an atypical antipsychotic developed by Dainippon Sumitomo Pharma and marketed by Sunovion in the U.S. It has been an FDA approved treatment for schizophrenia since 2010 and for treating depressive episodes in adults with bipolar I disorder since 2013.

New!!: 5-HT7 receptor and Lurasidone · See more »

LY-215,840

LY-215,840 is an ergoline derivative drug developed by Eli Lilly, which acts as a potent and selective antagonist at the serotonin 5-HT2 and 5-HT7 receptors.

New!!: 5-HT7 receptor and LY-215,840 · See more »

Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

New!!: 5-HT7 receptor and Major depressive disorder · See more »

Maprotiline

Maprotiline, sold under the brand name Ludiomil among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression.

New!!: 5-HT7 receptor and Maprotiline · See more »

Memory

Memory is the faculty of the mind by which information is encoded, stored, and retrieved.

New!!: 5-HT7 receptor and Memory · See more »

Mesulergine

No description.

New!!: 5-HT7 receptor and Mesulergine · See more »

Metergoline

Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.

New!!: 5-HT7 receptor and Metergoline · See more »

Methysergide

Methysergide (1-methyl-D-lysergic acid butanolamide or UML-491) also known as methysergide maleate, is an ergot derived prescription drug used for the prophylaxis of difficult to treat migraine and cluster headaches.

New!!: 5-HT7 receptor and Methysergide · See more »

Metitepine

Metitepine (developmental code names Ro 8-6837 (maleate), VUFB-6276 (mesylate)), also known as methiothepin, is a drug described as a "psychotropic agent" of the tricyclic group which was never marketed.

New!!: 5-HT7 receptor and Metitepine · See more »

Mianserin

Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant which is used in the treatment of depression in Europe and elsewhere in the world.

New!!: 5-HT7 receptor and Mianserin · See more »

Molecular binding

Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other.

New!!: 5-HT7 receptor and Molecular binding · See more »

Mood (psychology)

In psychology, a mood is an emotional state.

New!!: 5-HT7 receptor and Mood (psychology) · See more »

Muscle relaxant

A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.

New!!: 5-HT7 receptor and Muscle relaxant · See more »

N,N-Dimethyltryptamine

N,N-Dimethyltryptamine (DMT or N,N-DMT) is a tryptamine molecule which occurs in many plants and animals.

New!!: 5-HT7 receptor and N,N-Dimethyltryptamine · See more »

N-Methylserotonin

N-Methylserotonin is a tryptamine alkaloid.

New!!: 5-HT7 receptor and N-Methylserotonin · See more »

Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

New!!: 5-HT7 receptor and Neurotransmitter · See more »

Olanzapine

Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.

New!!: 5-HT7 receptor and Olanzapine · See more »

Paliperidone

Paliperidone, sold under the trade name Invega among others, is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications.

New!!: 5-HT7 receptor and Paliperidone · See more »

Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

New!!: 5-HT7 receptor and Partial agonist · See more »

Pimozide

Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class.

New!!: 5-HT7 receptor and Pimozide · See more »

Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

New!!: 5-HT7 receptor and Receptor (biochemistry) · See more »

Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

New!!: 5-HT7 receptor and Receptor antagonist · See more »

Risperidone

Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.

New!!: 5-HT7 receptor and Risperidone · See more »

Ritanserin

Ritanserin (INN, USAN, BAN) is a serotonin receptor antagonist which was never marketed for clinical use but has been used in scientific research.

New!!: 5-HT7 receptor and Ritanserin · See more »

SB-258719

SB-258719 is a drug developed by GlaxoSmithKline which acts as a selective 5-HT7 receptor partial inverse agonist, and was the first such ligand identified for 5-HT7.

New!!: 5-HT7 receptor and SB-258719 · See more »

SB-269970

SB-269970 is a drug and research chemical developed by GlaxoSmithKline used in scientific studies.

New!!: 5-HT7 receptor and SB-269970 · See more »

Second messenger system

Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers.

New!!: 5-HT7 receptor and Second messenger system · See more »

Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

New!!: 5-HT7 receptor and Serotonin · See more »

Sertindole

Sertindole (brand names: Serdolect and Serlect) is an antipsychotic medication.

New!!: 5-HT7 receptor and Sertindole · See more »

Sleep

Sleep is a naturally recurring state of mind and body, characterized by altered consciousness, relatively inhibited sensory activity, inhibition of nearly all voluntary muscles, and reduced interactions with surroundings.

New!!: 5-HT7 receptor and Sleep · See more »

Smooth muscle tissue

Smooth muscle is an involuntary non-striated muscle.

New!!: 5-HT7 receptor and Smooth muscle tissue · See more »

Spiperone

Spiperone (Spiroperidol; brand name: Spiropitan (JP)) is a typical antipsychotic and research chemical belonging to the butyrophenone chemical class.

New!!: 5-HT7 receptor and Spiperone · See more »

Thalamus

The thalamus (from Greek θάλαμος, "chamber") is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex, and the regulation of consciousness, sleep, and alertness.

New!!: 5-HT7 receptor and Thalamus · See more »

Thermoregulation

Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different.

New!!: 5-HT7 receptor and Thermoregulation · See more »

Trifluoperazine

Trifluoperazine, sold under a number of brand names, is a typical antipsychotic primarily used to treat schizophrenia.

New!!: 5-HT7 receptor and Trifluoperazine · See more »

Trifluoromethylphenylpiperazine

3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the piperazine chemical class.

New!!: 5-HT7 receptor and Trifluoromethylphenylpiperazine · See more »

Vortioxetine

Vortioxetine is an antidepressant medication that is prescribed to treat depression.

New!!: 5-HT7 receptor and Vortioxetine · See more »

Ziprasidone

Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic which is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder.

New!!: 5-HT7 receptor and Ziprasidone · See more »

Zotepine

Zotepine (brand names: Losizopilon (JP), Lodopin (ID, JP), Setous (JP), Zoleptil (CZ, PT, TR, UK†); where † indicates a formulation that has been discontinued) is an atypical antipsychotic drug indicated for acute and chronic schizophrenia.

New!!: 5-HT7 receptor and Zotepine · See more »

1-(2-Diphenyl)piperazine

1-(2-Diphenyl)piperazine, also known as RA-7, is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor.

New!!: 5-HT7 receptor and 1-(2-Diphenyl)piperazine · See more »

5-Carboxamidotryptamine

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.

New!!: 5-HT7 receptor and 5-Carboxamidotryptamine · See more »

5-HT receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.

New!!: 5-HT7 receptor and 5-HT receptor · See more »

5-HT1 receptor

The 5-HT1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT).

New!!: 5-HT7 receptor and 5-HT1 receptor · See more »

5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

New!!: 5-HT7 receptor and 5-HT1A receptor · See more »

5-HT2 receptor

The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

New!!: 5-HT7 receptor and 5-HT2 receptor · See more »

5-HT3 receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.

New!!: 5-HT7 receptor and 5-HT3 receptor · See more »

5-HT4 receptor

5-Hydroxytryptamine receptor 4 is a protein that in humans is encoded by the HTR4 gene.

New!!: 5-HT7 receptor and 5-HT4 receptor · See more »

5-HT5A receptor

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.

New!!: 5-HT7 receptor and 5-HT5A receptor · See more »

5-HT6 receptor

The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).

New!!: 5-HT7 receptor and 5-HT6 receptor · See more »

5-Methoxytryptamine

5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin.

New!!: 5-HT7 receptor and 5-Methoxytryptamine · See more »

8-OH-DPAT

8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor.

New!!: 5-HT7 receptor and 8-OH-DPAT · See more »

Redirects here:

5-HT7, HTR7, HTR7 (gene).

References

[1] https://en.wikipedia.org/wiki/5-HT7_receptor

OutgoingIncoming
Hey! We are on Facebook now! »