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Index 5α-Reductase

5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. [1]

88 relations: Acne, Aldosterone, Alfatradiol, Allopregnanolone, Androgen, Androstanedione, Androstenedione, Aqueous humour, Asparagine, Benign prostatic hyperplasia, Bile acid, Catalysis, Chemical reaction, Cholestenone 5alpha-reductase, Constipation, Corticosterone, Cortisol, Deoxycorticosterone, Depression (mood), Dihydrodeoxycorticosterone, Dihydrotestosterone, Dutasteride, Endoplasmic reticulum, Enzyme, Epididymis, Epitestosterone, Epithelium, Erectile dysfunction, Estradiol, Estrogen, Fatigue, Finasteride, Gamma-Aminobutyric acid, Ganoderic acid, Green tea, Gynecomastia, Hirsutism, Hypoglycemia, Immortalised cell line, Intersex, Isopregnanolone, Isozyme, Lens (anatomy), Lingzhi mushroom, Linolenic acid, List of enzymes, Lower urinary tract symptoms, Metabolism, Natriuresis, Nervous system, ..., Neurosteroid, Oxidoreductase, Papua New Guinea, Pattern hair loss, Polycystic ovary syndrome, Polyunsaturated fatty acid, Product (chemistry), Progesterone, Prostate, Prostate cancer, Protein, Pseudovaginal perineoscrotal hypospadias, Riboflavin, Seminal vesicle, Serenoa, Sex steroid, Skin, Small interfering RNA, SRD5A1, SRD5A2, SRD5A3, Steroidogenesis inhibitor, Steroidogenic enzyme, Substrate (chemistry), Testosterone, Tetrahydrodeoxycorticosterone, Trans woman, Transgender hormone therapy (male-to-female), Zinc, 17β-Hydroxysteroid dehydrogenase, 3α-Dihydroprogesterone, 3α-Hydroxysteroid dehydrogenase, 3β-Dihydroprogesterone, 3β-Hydroxysteroid dehydrogenase, 5α-Dihydrocorticosterone, 5α-Dihydroprogesterone, 5α-Reductase deficiency, 5α-Reductase inhibitor. Expand index (38 more) »


Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin.

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Aldosterone, the main mineralocorticoid hormone, is a steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland.

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Alfatradiol, also known as 17α-estradiol and sold under the brand names Avicis, Avixis, Ell-Cranell Alpha, and Pantostin, is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia (pattern hair loss) in men and women.

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Allopregnanolone, also known as 5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), as well as brexanolone, is an endogenous inhibitory pregnane neurosteroid.

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An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

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Androstanediones are a pair of isomeric steroids which differ at the 5-position.

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Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA).

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Aqueous humour

The aqueous humour is a transparent, watery fluid similar to plasma, but containing low protein concentrations.

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Asparagine (symbol Asn or N), is an α-amino acid that is used in the biosynthesis of proteins.

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Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate.

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Bile acid

Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates.

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Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.

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Cholestenone 5alpha-reductase

In enzymology, a cholestenone 5alpha-reductase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are 5alpha-cholestan-3-one and NADP+, whereas its 3 products are cholest-4-en-3-one, NADPH, and H+.

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Constipation refers to bowel movements that are infrequent or hard to pass.

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Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.

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Cortisol is a steroid hormone, in the glucocorticoid class of hormones.

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Deoxycorticosterone (DOC), or desoxycorticosterone, may refer to.

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Depression (mood)

Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.

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5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid.

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Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone.

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Dutasteride, sold under the brand name Avodart among others, is a medication used primarily to treat enlarged prostate in men.

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Endoplasmic reticulum

The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.

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Enzymes are macromolecular biological catalysts.

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The epididymis (plural: epididymides or) is a tube that connects a testicle to a vas deferens in the male reproductive system.

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Epitestosterone, or isotestosterone, also known as 17α-testosterone or as androst-4-en-17α-ol-3-one, is an endogenous steroid and an epimer of the androgen sex hormone testosterone.

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Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.

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Erectile dysfunction

Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity.

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Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.

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Estrogen, or oestrogen, is the primary female sex hormone.

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Fatigue is a subjective feeling of tiredness that has a gradual onset.

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Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used mainly to treat an enlarged prostate or scalp hair loss in men.

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Gamma-Aminobutyric acid

gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.

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Ganoderic acid

Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms.

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Green tea

Green tea is a type of tea that is made from Camellia sinensis leaves that have not undergone the same withering and oxidation process used to make oolong teas and black teas.

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Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.

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Hirsutism is excessive body hair in men and women on parts of the body where hair is normally absent or minimal, such as on the chin or chest in particular, or the face or body in general.

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Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels.

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Immortalised cell line

An immortalized cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.

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Intersex people are born with any of several variations in sex characteristics including chromosomes, gonads, sex hormones, or genitals that, according to the UN Office of the High Commissioner for Human Rights, "do not fit the typical definitions for male or female bodies".

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Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone, and as 3β-hydroxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone.

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Isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.

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Lens (anatomy)

The lens is a transparent, biconvex structure in the eye that, along with the cornea, helps to refract light to be focused on the retina.

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Lingzhi mushroom

The lingzhi mushroom is a species complex that encompasses several fungal species of the genus Ganoderma, most commonly the closely related species Ganoderma lucidum, Ganoderma tsugae, and Ganoderma lingzhi.

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Linolenic acid

Linolenic acid is a type of fatty acid.

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List of enzymes

This page lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission numbering system.

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Lower urinary tract symptoms

Lower urinary tract symptoms (LUTS) refer to a group of clinical symptoms involving the bladder, urinary sphincter, urethra, and, in men, the prostate.

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Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Natriuresis is the process of sodium excretion in the urine through the action of the kidneys.

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Nervous system

The nervous system is the part of an animal that coordinates its actions by transmitting signals to and from different parts of its body.

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Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.

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In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor.

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Papua New Guinea

Papua New Guinea (PNG;,; Papua Niugini; Hiri Motu: Papua Niu Gini), officially the Independent State of Papua New Guinea, is an Oceanian country that occupies the eastern half of the island of New Guinea and its offshore islands in Melanesia, a region of the southwestern Pacific Ocean north of Australia.

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Pattern hair loss

Pattern hair loss, known as male-pattern hair loss (MPHL) when it affects males and female-pattern hair loss (FPHL) when it affects females, is hair loss that primarily affects the top and front of the scalp.

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Polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a set of symptoms due to elevated androgens (male hormones) in females.

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Polyunsaturated fatty acid

Polyunsaturated fatty acids (PUFAs) are fatty acids that contain more than one double bond in their backbone.

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Product (chemistry)

Products are the species formed from chemical reactions.

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Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

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The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.

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Prostate cancer

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Pseudovaginal perineoscrotal hypospadias

Pseudovaginal perineoscrotal hypospadias (PPSH) refers to a configuration of the external genitalia of an infant.

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Riboflavin, also known as vitamin B2, is a vitamin found in food and used as a dietary supplement.

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Seminal vesicle

The seminal vesicles (glandulae vesiculosae), vesicular glands, or seminal glands, are a pair of simple tubular glands posteroinferior to the urinary bladder of some male mammals.

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Serenoa repens, commonly known as saw palmetto, is the sole species currently classified in the genus Serenoa.

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Sex steroid

Sex steroids, also known as gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate androgen or estrogen receptors.

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Skin is the soft outer tissue covering vertebrates.

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Small interfering RNA

Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway.

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3-oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene.

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3-oxo-5α-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.

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Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.

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Steroidogenesis inhibitor

A steroidogenesis inhibitor, also known as a steroid biosynthesis inhibitor, is a type of drug which inhibits one or more of the enzymes that are involved in the process of steroidogenesis, the biosynthesis of endogenous steroids and steroid hormones.

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Steroidogenic enzyme

Steroidogenic enzymes, or steroid-metabolizing enzymes, are enzymes that are involved in steroidogenesis and steroid metabolism.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

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Testosterone is the primary male sex hormone and an anabolic steroid.

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Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid.

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Trans woman

A trans woman (sometimes trans-woman or transwoman) is a woman who was assigned male at birth.

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Transgender hormone therapy (male-to-female)

Transgender hormone therapy of the male-to-female (MTF) type, also known as feminizing hormone therapy, is a form of hormone replacement therapy (HRT) and sex reassignment therapy which is used to change the secondary sexual characteristics of transgender people from masculine (or androgynous) to feminine.

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Zinc is a chemical element with symbol Zn and atomic number 30.

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17β-Hydroxysteroid dehydrogenase

17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism.

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3α-Dihydroprogesterone (3α-DHP), also known as 3α-hydroxyprogesterone, as well as pregn-4-en-3α-ol-20-one, is an endogenous neurosteroid.

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3α-Hydroxysteroid dehydrogenase

3α-hydroxysteroid dehydrogenase (3α-HSD), also known as aldo-keto reductase family 1 member C4, is an enzyme that in humans is encoded by the AKR1C4 gene.

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3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone, or pregn-4-en-3β-ol-20-one (4-pregnenolone, δ4-pregnenolone), is an endogenous steroid.

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3β-Hydroxysteroid dehydrogenase

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.

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5α-Dihydrocorticosterone (5α-DHC, 5α-DHB), also known as 11β,21-dihydroxy-5α-pregnane-3,20-dione, is a naturally occurring, endogenous glucocorticoid steroid hormone and neurosteroid.

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5α-Dihydroprogesterone (5α-DHP), also known as allopregnanedione, as well as 5α-pregnane-3,20-dione, is an endogenous progestogen and neurosteroid that is synthesized from progesterone.

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5α-Reductase deficiency

5α-Reductase deficiency (5-ARD) is an autosomal recessive intersex condition caused by a mutation of the 5α reductase type II gene.

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5α-Reductase inhibitor

5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss.

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Redirects here:

3-oxo-5a-steroid 4-dehydrogenase, 3-oxo-5alpha-steroid 4-dehydrogenase, 3-oxo-5alpha-steroid:acceptor Delta4-oxidoreductase, 5 a Reductase, 5 alpha reductase, 5 alpha-reductase, 5-Alpha reductase, 5-alpha reductase, 5-alpha-reductase, 5A-Reductase, 5AR, 5a-reductase, 5aReductase, 5α-reductase, EC, Testosterone 5-alpha-Reductase.


[1] https://en.wikipedia.org/wiki/5α-Reductase

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