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5α-Reductase inhibitor

Index 5α-Reductase inhibitor

5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss. [1]

96 relations: Acne, Aldosterone, Alfatradiol, Allopregnanolone, Allosteric modulator, Androgen, Androgen-dependent condition, Androstenedione, Antiandrogen, Anticonvulsant, Antidepressant, Antidiuretic, Anxiety, Anxiolytic, Aphrodisiac, Aqueous humour, Australian Medicines Handbook, Azasteroid, Benign prostatic hyperplasia, Bicalutamide, Breast, Breast pain, Cataract, China, Cohort study, Cortisol, CYP17A1 inhibitor, Dementia, Deoxycorticosterone, Depression (mood), Dietary supplement, Dihydrodeoxycorticosterone, Dihydrotestosterone, Discovery and development of 5α-reductase inhibitors, Dutasteride, Ejaculation, Endogeny (biology), Enzyme, Epitestosterone, Epristeride, Erectile dysfunction, Europe, Finasteride, GABAA receptor, Generic drug, Gynecomastia, Hirsutism, Hypoactive sexual desire disorder, Hypospermia, Infertility, ..., Intraoperative floppy iris syndrome, Japan, Lens (anatomy), Libido, List of 5α-reductase inhibitors, Lower urinary tract symptoms, Male breast cancer, Matching (statistics), Medication, Metabolism, Neurosteroid, Neurosteroidogenesis inhibitor, Nicotinamide adenine dinucleotide phosphate, Nonsteroidal antiandrogen, Over-the-counter drug, Patent, Pattern hair loss, Population study, Progesterone, Prostate, Prostate cancer, Quality of life, Rate-determining step, Saw palmetto extract, Self-harm, Serenoa, Sex steroid, Sexual dysfunction, Side effect, South Korea, SRD5A1, SRD5A2, SRD5A3, Steroid, Suicide, Testosterone, Tetrahydrodeoxycorticosterone, Tolerability, Trans woman, Transgender hormone therapy (male-to-female), 17β-Hydroxysteroid dehydrogenase, 3α-Androstanediol, 3α-Hydroxysteroid dehydrogenase, 3β-Hydroxysteroid dehydrogenase, 5α-Dihydroprogesterone, 5α-Reductase. Expand index (46 more) »


Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin.

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Aldosterone, the main mineralocorticoid hormone, is a steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland.

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Alfatradiol, also known as 17α-estradiol and sold under the brand names Avicis, Avixis, Ell-Cranell Alpha, and Pantostin, is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia (pattern hair loss) in men and women.

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Allopregnanolone, also known as 5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), as well as brexanolone, is an endogenous inhibitory pregnane neurosteroid.

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Allosteric modulator

In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.

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An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

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Androgen-dependent condition

An androgen-dependent condition, disease, disorder, or syndrome, is a medical condition that is, in part or full, dependent on, or is sensitive to, the presence of androgenic activity in the body.

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Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is an endogenous weak androgen steroid hormone and intermediate in the biosynthesis of estrone and of testosterone from dehydroepiandrosterone (DHEA).

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Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.

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Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.

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Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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An antidiuretic is a substance that helps to control fluid balance in an animal's body by reducing urination, opposing diuresis.

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Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.

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An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety.

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An aphrodisiac or love drug is a substance that increases libido when consumed.

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Aqueous humour

The aqueous humour is a transparent, watery fluid similar to plasma, but containing low protein concentrations.

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Australian Medicines Handbook

Australian Medicines Handbook (AMH) is a peer-reviewed medicines prescribing guide for Australian health professionals.

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An azasteroid is a type of steroid derivative which has one of the carbon atoms in the steroid ring system replaced by a nitrogen atom.

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Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate.

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Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer.

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The breast is one of two prominences located on the upper ventral region of the torso of primates.

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Breast pain

Breast pain is a medical symptom that is most often associated with a developing disease or condition of the breast.

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A cataract is a clouding of the lens in the eye which leads to a decrease in vision.

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China, officially the People's Republic of China (PRC), is a unitary one-party sovereign state in East Asia and the world's most populous country, with a population of around /1e9 round 3 billion.

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Cohort study

A cohort study is a particular form of longitudinal study that sample a cohort (a group of people who share a defining characteristic, typically those who experienced a common event in a selected period, such as birth or graduation), performing a cross-section at intervals through time.

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Cortisol is a steroid hormone, in the glucocorticoid class of hormones.

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CYP17A1 inhibitor

A CYP17A1 inhibitor is a type of drug which inhibits the enzyme CYP17A1.

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Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.

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Deoxycorticosterone (DOC), or desoxycorticosterone, may refer to.

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Depression (mood)

Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.

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Dietary supplement

A dietary supplement is a manufactured product intended to supplement the diet when taken by mouth as a pill, capsule, tablet, or liquid.

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5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid.

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Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone.

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Discovery and development of 5α-reductase inhibitors

This article is about the discovery and development of 5α-reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers.

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Dutasteride, sold under the brand name Avodart among others, is a medication used primarily to treat enlarged prostate in men.

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Ejaculation is the discharge of semen (normally containing sperm) from the male reproductory tract, usually accompanied by orgasm.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within an organism, tissue, or cell.

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Enzymes are macromolecular biological catalysts.

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Epitestosterone, or isotestosterone, also known as 17α-testosterone or as androst-4-en-17α-ol-3-one, is an endogenous steroid and an epimer of the androgen sex hormone testosterone.

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Epristeride, sold under the brand names Aipuliete and Chuanliu, is a medication which is used in the treatment of enlarged prostate in China.

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Erectile dysfunction

Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity.

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Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere.

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Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used mainly to treat an enlarged prostate or scalp hair loss in men.

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GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

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Generic drug

A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.

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Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.

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Hirsutism is excessive body hair in men and women on parts of the body where hair is normally absent or minimal, such as on the chin or chest in particular, or the face or body in general.

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Hypoactive sexual desire disorder

Hypoactive sexual desire disorder (HSDD) or inhibited sexual desire (ISD) is considered a sexual dysfunction and is characterized as a lack or absence of sexual fantasies and desire for sexual activity, as judged by a clinician.

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Hypospermia is a condition in which a man has an unusually low ejaculate (or semen) volume, less than 1.5 ml.

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Infertility is the inability of a person, animal or plant to reproduce by natural means.

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Intraoperative floppy iris syndrome

Intraoperative floppy iris syndrome (IFIS) is a complication that may occur during cataract extraction in certain patients.

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Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.

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Lens (anatomy)

The lens is a transparent, biconvex structure in the eye that, along with the cornea, helps to refract light to be focused on the retina.

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Libido, colloquially known as sex drive, is a person's overall sexual drive or desire for sexual activity.

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List of 5α-reductase inhibitors

This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.

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Lower urinary tract symptoms

Lower urinary tract symptoms (LUTS) refer to a group of clinical symptoms involving the bladder, urinary sphincter, urethra, and, in men, the prostate.

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Male breast cancer

Male breast cancer (male breast neoplasm) is a rare cancer in males that originates from the breast.

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Matching (statistics)

Matching is a statistical technique which is used to evaluate the effect of a treatment by comparing the treated and the non-treated units in an observational study or quasi-experiment (i.e. when the treatment is not randomly assigned).

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A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.

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Neurosteroidogenesis inhibitor

A neurosteroidogenesis inhibitor is a drug that inhibits the production of endogenous neurosteroids.

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Nicotinamide adenine dinucleotide phosphate

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

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Nonsteroidal antiandrogen

A nonsteroidal antiandrogen (NSAA) is an antiandrogen with a nonsteroidal chemical structure.

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Over-the-counter drug

Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a prescription from a healthcare professional, as opposed to prescription drugs, which may be sold only to consumers possessing a valid prescription.

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A patent is a set of exclusive rights granted by a sovereign state or intergovernmental organization to an inventor or assignee for a limited period of time in exchange for detailed public disclosure of an invention.

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Pattern hair loss

Pattern hair loss, known as male-pattern hair loss (MPHL) when it affects males and female-pattern hair loss (FPHL) when it affects females, is hair loss that primarily affects the top and front of the scalp.

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Population study

In the various fields of healthcare, a population study is a study of a group of individuals taken from the general population who share a common characteristic, such as age, sex, or health condition.

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Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

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The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.

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Prostate cancer

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.

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Quality of life

Quality of life (QOL) is the general well-being of individuals and societies, outlining negative and positive features of life.

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Rate-determining step

In chemical kinetics, the overall rate of a reaction is often approximately determined by the slowest step, known as the rate-determining step (RDS) or rate-limiting step.

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Saw palmetto extract

Saw palmetto extract is an extract of the fruit of the saw palmetto.

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Self-harm, also known as self-injury, is defined as the intentional, direct injuring of body tissue, done without suicidal intentions.

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Serenoa repens, commonly known as saw palmetto, is the sole species currently classified in the genus Serenoa.

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Sex steroid

Sex steroids, also known as gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate androgen or estrogen receptors.

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Sexual dysfunction

Sexual dysfunction (or sexual malfunction or sexual disorder) is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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South Korea

South Korea, officially the Republic of Korea (대한민국; Hanja: 大韓民國; Daehan Minguk,; lit. "The Great Country of the Han People"), is a country in East Asia, constituting the southern part of the Korean Peninsula and lying east to the Asian mainland.

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3-oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene.

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3-oxo-5α-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.

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Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.

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A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.

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Suicide is the act of intentionally causing one's own death.

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Testosterone is the primary male sex hormone and an anabolic steroid.

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Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid.

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Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient.

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Trans woman

A trans woman (sometimes trans-woman or transwoman) is a woman who was assigned male at birth.

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Transgender hormone therapy (male-to-female)

Transgender hormone therapy of the male-to-female (MTF) type, also known as feminizing hormone therapy, is a form of hormone replacement therapy (HRT) and sex reassignment therapy which is used to change the secondary sexual characteristics of transgender people from masculine (or androgynous) to feminine.

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17β-Hydroxysteroid dehydrogenase

17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism.

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3α-Androstanediol (often abbreviated as 3α-diol), also known as 5α-androstane-3α,17β-diol, is an endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT).

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3α-Hydroxysteroid dehydrogenase

3α-hydroxysteroid dehydrogenase (3α-HSD), also known as aldo-keto reductase family 1 member C4, is an enzyme that in humans is encoded by the AKR1C4 gene.

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3β-Hydroxysteroid dehydrogenase

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.

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5α-Dihydroprogesterone (5α-DHP), also known as allopregnanedione, as well as 5α-pregnane-3,20-dione, is an endogenous progestogen and neurosteroid that is synthesized from progesterone.

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5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.

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[1] https://en.wikipedia.org/wiki/5α-Reductase_inhibitor

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