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6-APB (6-(2-aminopropyl)benzofuran) is an empathogenic psychoactive compound of the substituted benzofuran, substituted amphetamine and substituted phenethylamine classes. [1]

79 relations: Acetal, Agonist, Alcohol, Aldehyde, Anorectic, Australia, Benzofuran, Benzofury, Betäubungsmittelgesetz, Binding selectivity, Biological target, BW-723C86, Carboxylic acid, Cardiotoxicity, Chloroform, Column chromatography, Controlled Drug in the United Kingdom, Controlled Drugs and Substances Act, Dopamine transporter, Drug metabolism, Drugs controlled by the German Betäubungsmittelgesetz, Drugs controlled by the UK Misuse of Drugs Act, Empathogen–entactogen, Federal Analogue Act, Fenfluramine, Froehde reagent, Functional group, Furan, Glucuronidation, Hydrochloride, Hydrogen chloride, Hydroxylation, Ion association, Liebermann reagent, Ligand (biochemistry), List of withdrawn drugs, Marquis reagent, Mecke reagent, Methylenedioxy, Monoamine neurotransmitter, Monoamine releasing agent, Monoamine transporter, Monobromophenol, Netherlands, New Zealand, Norepinephrine transporter, Opium Law, Pharmacokinetics, Phosphoric acids and phosphates, Potency (pharmacology), ..., Properties of water, Psychoactive drug, Psychosis, Redox, Research chemical, Reuptake, Reuptake inhibitor, Safe Streets Act, Serotonergic, Serotonin, Serotonin transporter, Serotonin-norepinephrine-dopamine releasing agent, Serotonin–norepinephrine–dopamine reuptake inhibitor, Silica gel, Sodium hydride, Structural analog, Structural isomer, Substituted amphetamine, Substituted benzofuran, Substituted phenethylamine, Temporary class drug, United Kingdom, United States, 3,4-Methylenedioxyamphetamine, 5-APB, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 6-APDB. Expand index (29 more) »


An acetal is a functional group with the following connectivity R2C(OR')2, where both R' groups are organic fragments.

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An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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In chemistry, an alcohol is any organic compound in which the hydroxyl functional group (–OH) is bound to a carbon.

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An aldehyde or alkanal is an organic compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen and to an R group, which is any generic alkyl or side chain.

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An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss.

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Australia, officially the Commonwealth of Australia, is a sovereign country comprising the mainland of the Australian continent, the island of Tasmania and numerous smaller islands.

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Benzofuran is the heterocyclic compound consisting of fused benzene and furan rings.

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Benzofury may refer to.

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The Betäubungsmittelgesetz (BtMG), generally meaning Narcotics Law, is the controlled-substances law of Germany.

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Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Biological target

A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.

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BW-723C86 is a tryptamine derivative drug which acts as a 5-HT2B receptor agonist.

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Carboxylic acid

A carboxylic acid is an organic compound that contains a carboxyl group (C(.

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Cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage.

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Chloroform, or trichloromethane, is an organic compound with formula CHCl3.

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Column chromatography

Column chromatography in chemistry is a chromatography method used to isolate a single chemical compound from a mixture.

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Controlled Drug in the United Kingdom

The United Kingdom Misuse of Drugs Act 1971 aimed to control the possession and supply of numerous listed drugs and drug-like substances as a controlled substance.

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Controlled Drugs and Substances Act

The Controlled Drugs and Substances Act (Loi réglementant certaines drogues et autres substances) (the Act) is Canada's federal drug control statute.

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Dopamine transporter

The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.

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Drug metabolism

Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems.

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Drugs controlled by the German Betäubungsmittelgesetz

Drugs controlled by the German Betäubungsmittelgesetz (BtMG).

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Drugs controlled by the UK Misuse of Drugs Act

Drugs controlled by the United Kingdom (UK) Misuse of Drugs Act 1971 are listed in this article.

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Empathogens or entactogens are a class of psychoactive drugs that produce experiences of emotional communion, oneness, relatedness, emotional openness—that is, empathy or sympathy—as particularly observed and reported for experiences with 3,4- Methylenedioxymethamphetamine (MDMA).

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Federal Analogue Act

The Federal Analogue Act,, is a section of the United States Controlled Substances Act passed in 1986 which allowed any chemical "substantially similar" to a controlled substance listed in Schedule I or II to be treated as if it were also listed in those schedules, but only if intended for human consumption.

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Fenfluramine, formerly sold under the brand name Pondimin among others, is an appetite suppressant which was used to treat obesity and is now no longer marketed.

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Froehde reagent

The Froehde reagent is used as a simple spot-test to presumptively identify alkaloids, especially opioids, as well as other compounds.

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Functional group

In organic chemistry, functional groups are specific substituents or moieties within molecules that are responsible for the characteristic chemical reactions of those molecules.

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Furan is a heterocyclic organic compound, consisting of a five-membered aromatic ring with four carbon atoms and one oxygen.

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Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

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In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).

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Hydrogen chloride

The compound hydrogen chloride has the chemical formula and as such is a hydrogen halide.

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Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.

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Ion association

In chemistry, ion association is a chemical reaction whereby ions of opposite electrical charge come together in solution to form a distinct chemical entity.

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Liebermann reagent

The Liebermann reagent named after Hungarian chemist Leo Liebermann (1852-1926) is used as a simple spot-test to presumptively identify alkaloids as well as other compounds.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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List of withdrawn drugs

Drugs or medicines may be withdrawn from commercial markets because of risks to patients, but also because of commercial reasons (e.g. lack of demand and relatively high production costs).

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Marquis reagent

Marquis reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds.

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Mecke reagent

The Mecke reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds.

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Methylenedioxy is the term used in the field of chemistry, particularly in organic chemistry, for a functional group with the structural formula R-O-CH2-O-R' which is connected to the rest of a molecule by two chemical bonds.

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Monoamine neurotransmitter

Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by a two-carbon chain (such as -CH2-CH2-). All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.

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Monoamine releasing agent

A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the release of a monoamine neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.

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Monoamine transporter

Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters.

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The monobromophenols are chemical compounds consisting of phenol substituted with a bromine atom.

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The Netherlands (Nederland), often referred to as Holland, is a country located mostly in Western Europe with a population of seventeen million.

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New Zealand

New Zealand (Aotearoa) is a sovereign island country in the southwestern Pacific Ocean.

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Norepinephrine transporter

The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.

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Opium Law

The Opium Law (or Opiumwet in Dutch) is the section of the Dutch law which covers nearly all psychotropic drugs.

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Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered to a living organism.

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Phosphoric acids and phosphates

There are various kinds of phosphoric acids and phosphates.

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Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

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Properties of water

Water is a polar inorganic compound that is at room temperature a tasteless and odorless liquid, which is nearly colorless apart from an inherent hint of blue. It is by far the most studied chemical compound and is described as the "universal solvent" and the "solvent of life". It is the most abundant substance on Earth and the only common substance to exist as a solid, liquid, and gas on Earth's surface. It is also the third most abundant molecule in the universe. Water molecules form hydrogen bonds with each other and are strongly polar. This polarity allows it to separate ions in salts and strongly bond to other polar substances such as alcohols and acids, thus dissolving them. Its hydrogen bonding causes its many unique properties, such as having a solid form less dense than its liquid form, a relatively high boiling point of 100 °C for its molar mass, and a high heat capacity. Water is amphoteric, meaning that it is both an acid and a base—it produces + and - ions by self-ionization.

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Psychoactive drug

A psychoactive drug, psychopharmaceutical, or psychotropic is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior.

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Psychosis is an abnormal condition of the mind that results in difficulties telling what is real and what is not.

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Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Research chemical

Research chemicals are chemical substances used by scientists for medical and scientific research purposes.

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Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

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Reuptake inhibitor

A reuptake inhibitor (RI) is a type of drug known as a reuptake modulator that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron.

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Safe Streets Act

The Safe Streets Act, 1999 is a statute in the province of Ontario, Canada.

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Serotonergic or serotoninergic means "pertaining to or affecting serotonin".

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Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Serotonin transporter

The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.

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Serotonin-norepinephrine-dopamine releasing agent

A serotonin–norepinephrine-dopamine releasing agent (SNDRA), also known as a triple releasing agent (TRA), is a type of drug which induces the release of serotonin, norepinephrine/epinephrine, and dopamine in the brain and body.

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Serotonin–norepinephrine–dopamine reuptake inhibitor

A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine.

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Silica gel

Silica gel is an amorphous and porous form of silicon dioxide (silica), consisting of an irregular tridimensional framework of alternating silicon and oxygen atoms with nanometer-scale voids and pores.

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Sodium hydride

Sodium hydride is the chemical compound with the empirical formula NaH.

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Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

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Structural isomer

Structural isomerism, or constitutional isomerism (per IUPAC), is a form of isomerism in which molecules with the same molecular formula have different bonding patterns and atomic organization, as opposed to stereoisomerism, in which molecular bonds are always in the same order and only spatial arrangement differs.

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Substituted amphetamine

Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents.

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Substituted benzofuran

The substituted benzofurans are a class of chemical compounds based on the heterocyclyc and polycyclic compound benzofuran.

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Substituted phenethylamine

Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents.

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Temporary class drug

A temporary class drug is a relatively new status for controlled drugs, which has been adopted in some jurisdictions, notably New Zealand and the United Kingdom, to attempt to bring newly synthesised designer drugs under legal control.

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United Kingdom

The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.

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United States

The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.

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3,4-Methylenedioxyamphetamine (MDA), is an empathogen-entactogen, psychostimulant, and psychedelic drug of the amphetamine family that is encountered mainly as a recreational drug.

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5-APB (abbreviation of "5-(2-aminopropyl)benzofuran"; see infobox for the correct IUPAC name) is an empathogenic psychoactive compound of the substituted benzofuran, substituted amphetamine and substituted phenethylamine classes.

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5-HT2A receptor

The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).

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5-HT2B receptor

5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.

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5-HT2C receptor

The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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6-(2-Aminopropyl)-2,3-dihydrobenzofuran (6-APDB, 4-Desoxy-MDA, EMA-3) is a stimulant and entactogen drug of the phenethylamine and amphetamine classes.

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Redirects here:

6-(2-Aminopropyl)benzofuran, 6-(2-aminopropyl)benzofuran, 6-apb, Eric-7, NRG-7.


[1] https://en.wikipedia.org/wiki/6-APB

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