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6-Pyruvoyltetrahydropterin synthase

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In enzymology, a 6-pyruvoyltetrahydropterin synthase (PTPS) is an enzyme that catalyzes the following chemical reaction: 7,8-Dihydroneopterin triphosphate \rightleftharpoons 6-pyruvoyltetrahydropterin + triphosphate This reaction is the second step (shown above) in the biosynthesis of Tetrahydrobiopterin from GTP, which is used as a cofactor in the synthesis of Aromatic amino acid Monooxygenases and Nitric oxide synthase PTPS converts 7,8-Dihydroneopterin triphosphate to 6-pyruvoyltetrahydropterin (PTP) through the loss of the triphosphate group, a stereospecific reduction of the double bond between the top right nitrogen and carbon in the ring on the ightht, The oxidation of the hydroxyl groups located on the first and second carbons of the side chain, and an internal base-catalyzed hydrogen tnsfer. 6-pyruvoyltetrahydropterin synthase (PTPS) can be found in the cytoplasm as well as the nucleus of cells according to immunohistochemical studies conducted. [1]

36 relations: Amino acid, Aromatic amino acid, Base (chemistry), Binding site, Catalysis, Cell (biology), Cell nucleus, Chemical reaction, Cytoplasm, Dimer (chemistry), Dominance (genetics), Dopamine, Dystonia, Enzyme, Epileptic seizure, Heredity, Histidine, Hydroxy group, Hyperphenylalaninemia, Immunohistochemistry, List of enzymes, Lyase, Monooxygenase, Neurotransmitter, Nitric oxide synthase, Polyphosphate, Post-translational modification, Protein quaternary structure, PTS (gene), Serotonin, Symmetry group, Tetrahydrobiopterin, Transition metal, Trimer (chemistry), Zygosity, 7,8-Dihydroneopterin triphosphate.

Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Aromatic amino acid

An aromatic amino acid (AAA) is an amino acid that includes an aromatic ring.

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Base (chemistry)

In chemistry, bases are substances that, in aqueous solution, release hydroxide (OH−) ions, are slippery to the touch, can taste bitter if an alkali, change the color of indicators (e.g., turn red litmus paper blue), react with acids to form salts, promote certain chemical reactions (base catalysis), accept protons from any proton donor, and/or contain completely or partially displaceable OH− ions.

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Binding site

In biochemistry, a binding site is a region on a protein or piece of DNA or RNA to which ligands (specific molecules and/or ions) may form a chemical bond.

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Catalysis

Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.

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Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

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Dimer (chemistry)

A dimer (di-, "two" + -mer, "parts") is an oligomer consisting of two monomers joined by bonds that can be either strong or weak, covalent or intermolecular.

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Dominance (genetics)

Dominance in genetics is a relationship between alleles of one gene, in which the effect on phenotype of one allele masks the contribution of a second allele at the same locus.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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Dystonia

Dystonia is a neurological movement disorder syndrome in which sustained or repetitive muscle contractions result in twisting and repetitive movements or abnormal fixed postures.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Epileptic seizure

An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

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Heredity

Heredity is the passing on of traits from parents to their offspring, either through asexual reproduction or sexual reproduction, the offspring cells or organisms acquire the genetic information of their parents.

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Histidine

Histidine (symbol His or H) is an α-amino acid that is used in the biosynthesis of proteins.

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Hydroxy group

A hydroxy or hydroxyl group is the entity with the formula OH.

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Hyperphenylalaninemia

Hyperphenylalaninemia is a medical condition characterized by mildly or strongly elevated concentrations of the amino acid phenylalanine in the blood.

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Immunohistochemistry

Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues.

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List of enzymes

This page lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission numbering system.

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Lyase

In biochemistry, a lyase is an enzyme that catalyzes the breaking (an "elimination" reaction) of various chemical bonds by means other than hydrolysis (a "substitution" reaction) and oxidation, often forming a new double bond or a new ring structure.

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Monooxygenase

Monooxygenases are enzymes that incorporate one hydroxyl group into substrates in many metabolic pathways.

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Nitric oxide synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.

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Polyphosphate

Polyphosphates are salts or esters of polymeric oxyanions formed from tetrahedral PO4 (phosphate) structural units linked together by sharing oxygen atoms.

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Post-translational modification

Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.

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Protein quaternary structure

Protein quaternary structure is the number and arrangement of multiple folded protein subunits in a multi-subunit complex.

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PTS (gene)

6-pyruvoyltetrahydropterin synthase, also known as PTS, is a human gene which facilitates folate biosynthesis.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Symmetry group

In group theory, the symmetry group of an object (image, signal, etc.) is the group of all transformations under which the object is invariant with composition as the group operation.

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Tetrahydrobiopterin

Tetrahydrobiopterin (BH4, THB), also known as sapropterin, is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases.

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Transition metal

In chemistry, the term transition metal (or transition element) has three possible meanings.

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Trimer (chemistry)

In chemistry, a trimer is a molecule or an anion formed by combination or association of three molecules or ions of the same substance.

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Zygosity

Zygosity is the degree of similarity of the alleles for a trait in an organism.

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7,8-Dihydroneopterin triphosphate

7,8-Dihydroneopterin triphosphate (DHNTP) is an intermediate in tetrahydrobiopterin biosynthesis.

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Redirects here:

6-Pyruvoyl-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, 7,8-dihydroneopterin 3'-triphosphate triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming), EC 4.2.3.12.

References

[1] https://en.wikipedia.org/wiki/6-Pyruvoyltetrahydropterin_synthase

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