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7,12-Dimethylbenzanthracene (DMBA) is an immunosuppressor and a powerful organ-specific laboratory carcinogen. [1]

6 relations: Carcinogen, Immunosuppression, Sigma-Aldrich, Tumor initiation, Tumor promotion, 12-O-Tetradecanoylphorbol-13-acetate.


A carcinogen is any substance, radionuclide, or radiation that is an agent directly involved in causing cancer.

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Immunosuppression is a reduction of the activation or efficacy of the immune system.

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Sigma-Aldrich Corporation is an American life science and high technology company with over 9,600 employees and operations in 40 countries.

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Tumor initiation

Tumor initiation is defined as "a process in which normal cells are changed so that they are able to form tumors".

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Tumor promotion

Tumor promotion is a process in carcinogenesis by which various factors permit the descendents of a single initiated cell to survive and expand in number, i.e. to resist apoptosis and to undergo clonal growth.

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12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA), is a diester of phorbol and a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC).

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Redirects here:

7,12-dimethylbenz(a)anthracene, 7,12-dimethylbenz(α)anthracene, C20H16, Dimethylbenzanthracene.


[1] https://en.wikipedia.org/wiki/7,12-Dimethylbenz(a)anthracene

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