46 relations: Agonist, Aldehyde dehydrogenase, Alzheimer's disease, Amitriptyline, Amyotrophic lateral sclerosis, Antiestrogen, Antioxidant, Aromatase inhibitor, Bioavailability, Blood–brain barrier, Brain ischemia, Brain-derived neurotrophic factor, Central nervous system, Cognitive deficit, Depression (mood), Diosmetin, Dopaminergic, Emotion and memory, Excitotoxicity, Flavones, Flavonoid, Fragile X syndrome, Genotoxicity, Glutamic acid, Half-life, HIOC, Huntington's disease, Memory consolidation, Methamphetamine, Model organism, Mouth, N-Acetylserotonin, Natural product, Neurotoxicity, Oxidative stress, Oxidopamine, Parkinson's disease, Receptor (biochemistry), Rett syndrome, Schizophrenia, Small molecule, SULT1E1, Traumatic brain injury, Tridax procumbens, Tropomyosin receptor kinase B, 17Beta Hydroxysteroid dehydrogenase.
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Aldehyde dehydrogenases are a group of enzymes that catalyse the oxidation (dehydrogenation) of aldehydes.
Alzheimer's disease (AD), also known as Alzheimer disease, or just Alzheimer's, accounts for 60% to 70% of cases of dementia.
Amitriptyline (Elavil, Endep, Levate, and many others) is the most widely used tricyclic antidepressant (TCA).
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease and Charcot disease, is a specific disorder that involves the death of neurons.
An antiestrogen is a substance that blocks the production or utilization of estrogens,, or inhibits their effects.
An antioxidant is a molecule that inhibits the oxidation of other molecules.
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Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer and ovarian cancer in postmenopausal women and gynecomastia in men.
In pharmacology, bioavailability (BA) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid (BECF) in the central nervous system (CNS).
Brain ischemia (aka cerebral ischemia, cerebrovascular ischemia) is a condition in which there is insufficient blood flow to the brain to meet metabolic demand.
Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF gene.
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
Cognitive deficit or cognitive impairment is an inclusive term to describe any characteristic that acts as a barrier to the cognition process.
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings and sense of well-being.
Diosmetin is an O-methylated flavone, a chemical compound that can be found in the Caucasian vetch It has been found to act as a weak TrkB receptor agonist.
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Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter.
Emotion can have a powerful impact on memory.
Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.
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Flavonoids (or bioflavonoids) (from the Latin word flavus meaning yellow, their color in nature) are a class of plant secondary metabolites.
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Fragile X syndrome (FXS), also known as Martin–Bell syndrome, or Escalante's syndrome (more commonly used in South American countries), is a genetic syndrome.
In genetics, genotoxicity describes the property of chemical agents that damages the genetic information within a cell causing mutations, which may lead to cancer.
Glutamic acid (abbreviated as Glu or E) is one of the 20-23 proteinogenic amino acids, and its codons are GAA and GAG.
Half-life (t1⁄2) is the amount of time required for the amount of something to fall to half its initial value.
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HIOC is a small-molecule agent which acts as a selective TrkB receptor agonist (active at at least 100 nM; prominent activation at 500 nM).
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Huntington's disease (HD) is a neurodegenerative genetic disorder that affects muscle coordination and leads to mental decline and behavioral symptoms.
Memory consolidation is a category of processes that stabilize a memory trace after its initial acquisition.
Methamphetamine (contracted from) is a strong central nervous system (CNS) stimulant that is mainly used as a recreational drug.
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.
In biological anatomy, commonly referred to as the mouth, under formal names such as the oral cavity, buccal cavity, or in Latin cavum oris, is the opening through which many animals take in food and issue vocal sounds.
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N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin.
A natural product is a chemical compound or substance produced by a living organism—that is, found in nature.
Neurotoxicity occurs when exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system in such a way as to cause damage to nervous tissue.
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.
Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain.
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Parkinson's disease (PD, also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome (HRS), or paralysis agitans) is a degenerative disorder of the central nervous system mainly affecting the motor system.
In biochemistry and pharmacology, a receptor is a protein molecule usually found embedded within the plasma membrane surface of a cell that receives chemical signals from outside the cell.
Rett syndrome (RTT), originally termed cerebroatrophic hyperammonemia, is a rare genetic postnatal neurological disorder of the grey matter of the brain that almost exclusively affects females but has also been found in male patients.
Schizophrenia is a mental disorder often characterized by abnormal social behavior and failure to recognize what is real.
In molecular biology and pharmacology, a small molecule is a low molecular weight organic compound that may help regulate a biological process, with a size on the order of.
Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.
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Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force traumatically injures the brain.
Tridax procumbens, commonly known as coat buttons or tridax daisy, is a species of flowering plant in the daisy family.
Tropomyosin receptor kinase B (TrkB), also known as Tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene.
17β-Hydroxysteroid dehydrogenases (beta-hydroxy steroid dehydrogenase, 17-ketoreductase, 17beta-hydroxy steroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxy steroid dehydrogenase, 17β-HSD, 17-ketosteroid oxidoreductases, HSD17B, 17-ketosteroid reductases, 17-KSR), are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis.