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21 relations: Active metabolite, Androgen receptor, Antiandrogen, Antimineralocorticoid, Area under the curve (pharmacokinetics), Biological half-life, Canrenone, Cmax (pharmacology), Dihydrotestosterone, Ligand (biochemistry), Membrane transport protein, Metabolite, Prodrug, Prostate, Sex hormone-binding globulin, Spirolactone, Spironolactone, Steroid, 6β-Hydroxy-7α-thiomethylspironolactone, 7α-Thiomethylspironolactone, 7α-Thioprogesterone.
Active metabolite
An active metabolite is an active form of a drug after it has been processed by the body.
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Androgen receptor
The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
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Antiandrogen
Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.
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Antimineralocorticoid
An antimineralocorticoid, MCRA, or an aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors.
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Area under the curve (pharmacokinetics)
In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral in a plot of drug concentration in blood plasma vs.
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Biological half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
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Canrenone
Canrenone, sold under the brand names Contaren, Luvion, Phanurane, and Spiroletan, is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone which is used as a diuretic in Europe, including in Italy and Belgium.
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Cmax (pharmacology)
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and before the administration of a second dose.
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Dihydrotestosterone
Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Membrane transport protein
A membrane transport protein (or simply transporter) is a membrane protein involved in the movement of ions, small molecules, or macromolecules, such as another protein, across a biological membrane.
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Metabolite
A metabolite is the intermediate end product of metabolism.
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Prodrug
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
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Prostate
The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.
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Sex hormone-binding globulin
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to the two sex hormones: androgen and estrogen.
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Spirolactone
Spirolactones are a class of functional group in organic chemistry featuring a cyclic ester attatched spiro to another ring system.
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Spironolactone
Spironolactone, sold under the brand name Aldactone among others, is a medication that is primarily used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.
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Steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
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6β-Hydroxy-7α-thiomethylspironolactone
6β-Hydroxy-7α-thiomethylspironolactone (6β-OH-7α-TMS) is a steroidal antimineralocorticoid of the spirolactone group and a major active metabolite of spironolactone.
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7α-Thiomethylspironolactone
7α-Thiomethylspironolactone (7α-TMS; developmental code name SC-26519) is a steroidal antimineralocorticoid and antiandrogen of the spirolactone group and the major active metabolite of spironolactone.
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7α-Thioprogesterone
7α-Thioprogesterone (7α-TP4; developmental code name SC-8365; also known as 7α-mercaptopregn-4-ene-3,20-dione) is a synthetic, steroidal, and potent antimineralocorticoid (putative) and antiandrogen which was developed by G. D. Searle & Co and was described in the late 1970s and early 1980s but was never developed or introduced for medical use.
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Redirects here:
7-Mercaptospironolactone, 7-TS, 7-Thiospironolactone, 7-mercaptospironolactone, 7-thiospironolactone, 7α-Mercaptospironolactone, 7α-TS, 7α-mercaptospironolactone, 7α-thiospironolactone, Deacetylspironolactone, Mercaptospironolactone, SC 24,813, SC 24813, SC-24,813, SC-24813, SC24813, Thiospironolactone.
References
[1] https://en.wikipedia.org/wiki/7α-Thiospironolactone
