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7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase

Index 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase

In enzymology, a 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are 7alpha-hydroxycholest-4-en-3-one (7 alpha-hydroxy-4-cholesten-3-one, NADPH, H+, and O2, whereas its 3 products are 7alpha,12alpha-dihydroxycholest-4-en-3-one, NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating). This enzymatic activity is performed by CYP8B1. Other names used include 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase, CYP12, sterol 12alpha-hydroxylase (ambiguous), and HCO 12alpha-hydroxylase. This enzyme participates in ppar signaling pathway. [1]

13 relations: Catalysis, Chemical reaction, CYP8B1, Enzyme, Hydrogen ion, List of enzymes, Nicotinamide adenine dinucleotide phosphate, Oxidoreductase, Oxygen, Product (chemistry), Substrate (chemistry), Water, 7α-Hydroxy-4-cholesten-3-one.

Catalysis

Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Chemical reaction

A chemical reaction is a process that leads to the transformation of one set of chemical substances to another.

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CYP8B1

CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) also known as sterol 12-alpha-hydroxylase is a protein which in humans is encoded by the CYP8B1 gene.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Hydrogen ion

A hydrogen ion is created when a hydrogen atom loses or gains an electron.

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List of enzymes

This page lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission numbering system.

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Nicotinamide adenine dinucleotide phosphate

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.

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Oxidoreductase

In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor.

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Oxygen

Oxygen is a chemical element with symbol O and atomic number 8.

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Product (chemistry)

Products are the species formed from chemical reactions.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

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Water

Water is a transparent, tasteless, odorless, and nearly colorless chemical substance that is the main constituent of Earth's streams, lakes, and oceans, and the fluids of most living organisms.

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7α-Hydroxy-4-cholesten-3-one

7α-Hydroxy-4-cholesten-3-one is an intermediate in the biochemical synthesis of bile acids from cholesterol.

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Redirects here:

7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating), EC 1.14.13.95.

References

[1] https://en.wikipedia.org/wiki/7alpha-hydroxycholest-4-en-3-one_12alpha-hydroxylase

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