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7α-Hydroxy-4-cholesten-3-one

Index 7α-Hydroxy-4-cholesten-3-one

7α-Hydroxy-4-cholesten-3-one is an intermediate in the biochemical synthesis of bile acids from cholesterol. [1]

10 relations: Bile acid, Bile acid malabsorption, Chenodeoxycholic acid, Cholesterol, Cholesterol 7 alpha-hydroxylase, Cholic acid, FGF19, SeHCAT, 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase, 7α-Hydroxycholesterol.

Bile acid

Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates.

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Bile acid malabsorption

Bile acid malabsorption, known also as bile acid diarrhea, is a cause of several gut-related problems, the main one being chronic diarrhea.

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Chenodeoxycholic acid

Chenodeoxycholic acid (also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid.

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Cholesterol

Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.

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Cholesterol 7 alpha-hydroxylase

Cholesterol 7 alpha-hydroxylase also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A1) is an enzyme that in humans is encoded by the CYP7A1 gene which has an important role in cholesterol metabolism.

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Cholic acid

Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance.

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FGF19

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene.

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SeHCAT

SeHCAT (23-seleno-25-homotaurocholic acid, selenium homocholic acid taurine, or tauroselcholic acid) is a drug used in a clinical test to diagnose bile acid malabsorption.

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7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase

In enzymology, a 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are 7alpha-hydroxycholest-4-en-3-one (7 alpha-hydroxy-4-cholesten-3-one, NADPH, H+, and O2, whereas its 3 products are 7alpha,12alpha-dihydroxycholest-4-en-3-one, NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating). This enzymatic activity is performed by CYP8B1. Other names used include 7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase, CYP12, sterol 12alpha-hydroxylase (ambiguous), and HCO 12alpha-hydroxylase. This enzyme participates in ppar signaling pathway.

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7α-Hydroxycholesterol

7α-Hydroxycholesterol is a precursor of bile acids, created by cholesterol 7α-hydroxylase.

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Redirects here:

7 alpha-hydroxy-4-cholesten-3-one, 7α-hydroxy-4-cholesten-3-one.

References

[1] https://en.wikipedia.org/wiki/7α-Hydroxy-4-cholesten-3-one

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