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8-OH-DPAT

Index 8-OH-DPAT

8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. [1]

25 relations: Agonist, Analgesic, Anorectic, Antidepressant, Antiemetic, Anxiolytic, Bay R 1531, Binding selectivity, Bradycardia, British Journal of Pharmacology, Chemical classification, Hyperventilation, Hypotension, Hypothermia, MDAT, Research chemical, Serenic, Serotonin releasing agent, Serotonin reuptake inhibitor, UH-301, 2-Aminotetralin, 5-HT1A receptor, 5-HT7 receptor, 5-OH-DPAT, 7-OH-DPAT.

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Analgesic

An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.

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Anorectic

An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss.

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Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Antiemetic

An antiemetic is a drug that is effective against vomiting and nausea.

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Anxiolytic

An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety.

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Bay R 1531

Bay R 1531 is a tricyclic tryptamine derivative which acts as a selective serotonin receptor 5-HT1A agonist.

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Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Bradycardia

Bradycardia is a condition wherein an individual has a very slow heart rate, typically defined as a resting heart rate of under 60 beats per minute (BPM) in adults.

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British Journal of Pharmacology

The British Journal of Pharmacology is a biweekly peer-reviewed medical journal covering all aspects of experimental pharmacology.

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Chemical classification

Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties.

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Hyperventilation

Hyperventilation (a.k.a. overbreathing) occurs when the rate or tidal volume of breathing eliminates more carbon dioxide than the body can produce.

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Hypotension

Hypotension is low blood pressure, especially in the arteries of the systemic circulation.

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Hypothermia

Hypothermia is reduced body temperature that happens when a body dissipates more heat than it absorbs.

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MDAT

6,7-Methylenedioxy-2-aminotetralin (MDAT) is a drug developed in the 1990s by a team at Purdue University led by David E. Nichols.

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Research chemical

Research chemicals are chemical substances used by scientists for medical and scientific research purposes.

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Serenic

A serenic, or antiaggressive agent, is a type of drug which reduces the capacity for irritability and aggression.

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Serotonin releasing agent

A serotonin releasing agent (SRA) is a type of drug that induces the release of serotonin into the neuronal synaptic cleft.

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Serotonin reuptake inhibitor

A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) by blocking the action of the serotonin transporter (SERT).

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UH-301

UH-301 is a drug and research chemical widely used in scientific studies.

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2-Aminotetralin

2-Aminotetralin (2-AT), also known as 1,2,3,4-tetrahydronaphthalen-2-amine (THN), is a stimulant drug with a chemical structure consisting of a tetralin group combined with an amine.

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5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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5-HT7 receptor

The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.

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5-OH-DPAT

5-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with selectivity for the D2 receptor and D3 receptor subtypes.

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7-OH-DPAT

7-OH-DPAT is a synthetic compound that acts as a dopamine receptor agonist with reasonable selectivity for the D3 receptor subtype, and low affinity for serotonin receptors, unlike its structural isomer 8-OH-DPAT.

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Redirects here:

8-Hydroxy-N,N-dipropyl-2-aminotetralin, 8-Hydroxy-N,N-dipropylaminotetralin, 8-Hydroxydipropylaminotetralin, 8-hydroxy-2-(di-n-propylamino)tetralin, 8-hydroxy-N,N-dipropyl-2-aminotetralin, 8-hydroxy-N,N-dipropylaminotetralin.

References

[1] https://en.wikipedia.org/wiki/8-OH-DPAT

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