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8-Oxoguanine

Index 8-Oxoguanine

8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OH8Gua) is one of the most common DNA lesions resulting from reactive oxygen species and can result in a mismatched pairing with adenine resulting in G to T and C to A substitutions in the genome. [1]

17 relations: Adenine, Ageing, Base excision repair, Cancer, Carcinogenesis, Cellular respiration, DNA, DNA glycosylase, Guanine, Ionizing radiation, Mutagenesis, Mutation, Oxidative stress, Oxoguanine glycosylase, PubChem, Reactive oxygen species, 8-Oxo-2'-deoxyguanosine.

Adenine

Adenine (A, Ade) is a nucleobase (a purine derivative).

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Ageing

Ageing or aging (see spelling differences) is the process of becoming older.

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Base excision repair

In biochemistry and genetics, base excision repair (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.

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Cellular respiration

Cellular respiration is a set of metabolic reactions and processes that take place in the cells of organisms to convert biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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DNA glycosylase

DNA glycosylases are a family of enzymes involved in base excision repair, classified under EC number EC 3.2.2.

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Guanine

Guanine (or G, Gua) is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA).

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Ionizing radiation

Ionizing radiation (ionising radiation) is radiation that carries enough energy to liberate electrons from atoms or molecules, thereby ionizing them.

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Mutagenesis

Mutagenesis is a process by which the genetic information of an organism is changed, resulting in a mutation.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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Oxoguanine glycosylase

8-Oxoguanine glycosylase also known as OGG1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene.

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PubChem

PubChem is a database of chemical molecules and their activities against biological assays.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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8-Oxo-2'-deoxyguanosine

8-Oxo-2'-deoxyguanosine (8-oxo-dG) is an oxidized derivative of deoxyguanosine.

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Redirects here:

8-hydroxyguanine, 8-oxo-guanine, 8-oxoguanine, Hydroxyguanine, Oxoguanine.

References

[1] https://en.wikipedia.org/wiki/8-Oxoguanine

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