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36 relations: Agonist, Anabolism, Androgen, Animal testing on rodents, Binding selectivity, Bioassay, Bone density, Bone resorption, Diarylpropionitrile, ERB-196, Erteberel, Estradiol (medication), Estrogen (medication), Estrogen receptor alpha, Estrogen receptor beta, FERb 033, Insulin-like growth factor 1, Levator ani, Ligand (biochemistry), Muscle hypertrophy, Myogenesis, Organic compound, Ossification, Ovarian follicle, Potency (pharmacology), Prinaberel, Protein, Scientific method, Skeletal muscle, Testosterone, Transactivation, Uterus, WAY-166818, WAY-200070, WAY-214156, 16α-LE2.
Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Anabolism
Anabolism (from ἁνά, "upward" and βάλλειν, "to throw") is the set of metabolic pathways that construct molecules from smaller units.
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Androgen
An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.
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Animal testing on rodents
Rodents are commonly used in animal testing, particularly mice and rats, but also guinea pigs, hamsters, gerbils and others.
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Binding selectivity
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
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Bioassay
A bioassay is an analytical method to determine concentration or potency of a substance by its effect on living cells or tissues.
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Bone density
Bone density, or bone mineral density (BMD), is the amount of bone mineral in bone tissue.
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Bone resorption
Bone reabsorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones and release the minerals, resulting in a transfer of calcium from bone tissue to the blood.
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Diarylpropionitrile
Diarylpropionitrile (DPN), also known as 2,3-bis(p-hydroxyphenyl)propionitrile (2,3-BHPPN), is a synthetic, nonsteroidal, and highly selective agonist of ERβ (IC50.
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ERB-196
ERB-196, also known as WAY-202196, is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ.
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Erteberel
Erteberel (former developmental code name LY-500307), also known as selective estrogen receptor beta agonist-1 (SERBA-1), is a synthetic, nonsteroidal estrogen which acts as a selective ERβ agonist and is under development by Eli Lilly for the treatment of schizophrenia.
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Estradiol (medication)
Estradiol, also spelled oestradiol, is a medication and naturally occurring steroid hormone.
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Estrogen (medication)
An estrogen is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.
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Estrogen receptor alpha
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen.
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Estrogen receptor beta
Estrogen receptor beta (ER-β), also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2), is one of two main types of estrogen receptor, a nuclear receptor which is activated by the sex hormone estrogen.
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FERb 033
FERb 033 is a synthetic, nonsteroidal estrogen that was synthesized in 2009 and is used in scientific research.
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Insulin-like growth factor 1
Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene.
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Levator ani
The levator ani is a broad, thin muscle, situated on either side of the pelvis.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Muscle hypertrophy
Muscle hypertrophy involves an increase in size of skeletal muscle through a growth in size of its component cells.
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Myogenesis
Myogenesis is the formation of muscular tissue, particularly during embryonic development.
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Organic compound
In chemistry, an organic compound is generally any chemical compound that contains carbon.
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Ossification
Ossification (or osteogenesis) in bone remodeling is the process of laying down new bone material by cells called osteoblasts.
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Ovarian follicle
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries.
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Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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Prinaberel
Prinaberel (INN, USAN) (developmental code names ERB-041, WAY-202041) is a synthetic, nonsteroidal, and highly selective agonist of the ERβ subtype of the estrogen receptor.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Scientific method
Scientific method is an empirical method of knowledge acquisition, which has characterized the development of natural science since at least the 17th century, involving careful observation, which includes rigorous skepticism about what one observes, given that cognitive assumptions about how the world works influence how one interprets a percept; formulating hypotheses, via induction, based on such observations; experimental testing and measurement of deductions drawn from the hypotheses; and refinement (or elimination) of the hypotheses based on the experimental findings.
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Skeletal muscle
Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle.
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Testosterone
Testosterone is the primary male sex hormone and an anabolic steroid.
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Transactivation
In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological processes or by artificial means, through the expression of an intermediate transactivator protein.
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Uterus
The uterus (from Latin "uterus", plural uteri) or womb is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.
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WAY-166818
WAY-166818 is a synthetic, nonsteroidal estrogen related to WAY-200070 which is used in scientific research.
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WAY-200070
WAY-200070 is a synthetic, nonsteroidal, highly selective agonist of ERβ.
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WAY-214156
WAY-214156 is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ.
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16α-LE2
16α-LE2, or 16α-lactone-estradiol, also known as 3,17β-dihydroxy-19-nor-17α-pregna-1,3,5-(10)-triene-21,16α-lactone, is a synthetic, steroidal estrogen featuring a estradiol core.
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Redirects here:
8-Vinylestradiol, 8-vinylestradiol, 8β-Vinylestradiol, 8β-vinylestradiol.
References
[1] https://en.wikipedia.org/wiki/8β-VE2
