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AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma. [1]

14 relations: Agonist, AL-38022A, Blood–brain barrier, Glaucoma, Indazole, Intraocular pressure, Lipophilicity, Psilocin, Psychedelic drug, Receptor (biochemistry), Ro60-0175, VER-3323, YM-348, 5-HT2A receptor.


An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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AL-38022A is an indazole derivative drug which is one of a range of similar drugs developed for scientific research and with some possible clinical applications.

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Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).

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Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.

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Indazole, also called isoindazole, is a heterocyclic aromatic organic compound.

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Intraocular pressure

Intraocular pressure (IOP) is the fluid pressure inside the eye.

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Lipophilicity (from Greek λίπος "fat" and φίλος "friendly"), refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.

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Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance.

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Psychedelic drug

Psychedelics are a class of drug whose primary action is to trigger psychedelic experiences via serotonin receptor agonism, causing thought and visual/auditory changes, and altered state of consciousness.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Ro60-0175 is a drug developed by Hoffmann–La Roche, which has applications in scientific research.

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VER-3323 is a drug which acts as a selective agonist for both the 5-HT2B and 5-HT2C serotonin receptor subtypes, with moderate selectivity for 5-HT2C, but relatively low affinity for 5-HT2A.

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YM-348 is an indazole derivative drug which acts as a potent and selective 5-HT2C receptor agonist, with an EC50 of 1nM and 15x selectivity over 5-HT2A, although it only has moderate selectivity of 3x over the closely related 5-HT2B receptor.

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5-HT2A receptor

The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).

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[1] https://en.wikipedia.org/wiki/AL-34662

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