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AP5

Index AP5

AP5 or APV ((2R)-amino-5-phosphonovaleric acid; (2R)-amino-5-phosphonopentanoate) is a selective NMDA receptor antagonist that competitively inhibits the ligand (glutamate) binding site of NMDA receptors. [1]

19 relations: AMPA, AMPA receptor, AP-7 (drug), BAPTA, Calcium, California sea hare, Chelation, Classical conditioning, Competitive inhibition, Glutamic acid, In vitro, Isomer, Kainate receptor, Kainic acid, Long-term potentiation, NMDA receptor, NMDA receptor antagonist, Racemic mixture, Silent synapse.

AMPA

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.

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AMPA receptor

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS).

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AP-7 (drug)

AP-7 is a selective NMDA receptor (NMDAR) antagonist that competitively inhibits the glutamate binding site and thus activation of NMDAR.

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BAPTA

BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) is a calcium-specific aminopolycarboxylic acid.

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Calcium

Calcium is a chemical element with symbol Ca and atomic number 20.

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California sea hare

The California sea hare, scientific name Aplysia californica, is a species of sea slug in the sea hare family, Aplysiidae.

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Chelation

Chelation is a type of bonding of ions and molecules to metal ions.

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Classical conditioning

Classical conditioning (also known as Pavlovian or respondent conditioning) refers to a learning procedure in which a biologically potent stimulus (e.g. food) is paired with a previously neutral stimulus (e.g. a bell).

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Competitive inhibition

Competitive inhibition is a form of enzyme inhibition where binding of an inhibitor prevents binding of the target molecule of the enzyme, also known as the substrate.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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Isomer

An isomer (from Greek ἰσομερής, isomerès; isos.

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Kainate receptor

Kainate receptors, or kainic acid receptors (KARs), are ionotropic receptors that respond to the neurotransmitter glutamate.

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Kainic acid

Kainic acid, or kainate, is an acid that naturally occurs in some seaweed.

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Long-term potentiation

In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity.

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NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.

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NMDA receptor antagonist

NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor (NMDAR).

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Racemic mixture

In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.

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Silent synapse

In neuroscience, a silent synapse is an excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type glutamate receptors but no AMPA-type glutamate receptors.

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Redirects here:

2-Amino-5-phosphonovalerate, 2-amino-5-phosphonovalerate, AP-5, APV (NMDAR antagonist), APV (NMDAR), APV (drug), D-AP5.

References

[1] https://en.wikipedia.org/wiki/AP5

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