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ASK1

Index ASK1

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase kinase kinase family and as such a part of mitogen-activated protein kinase pathway. [1]

26 relations: C-Jun N-terminal kinases, C-Raf, CDC25A, CIB1, Coiled coil, Death-associated protein 6, DUSP19, GADD45B, HSPA1A, Locus (genetics), MAP2K6, MAP3K7, MAPK8IP3, Mitogen-activated protein kinase, Oxidative stress, P38 mitogen-activated protein kinases, PDCD6, PPP5C, Protein kinase R, Protein–protein interaction, RB1CC1, Thioredoxin, TRAF2, TRAF5, TRAF6, Unfolded protein response.

C-Jun N-terminal kinases

c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain.

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C-Raf

RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the RAF1 gene.

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CDC25A

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

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CIB1

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene.

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Coiled coil

A coiled coil is a structural motif in proteins in which 2–7 alpha-helices are coiled together like the strands of a rope (dimers and trimers are the most common types).

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Death-associated protein 6

Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene.

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DUSP19

Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.

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GADD45B

Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene.

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HSPA1A

Heat shock 70 kDa protein 1, also termed Hsp72, is a protein that in humans is encoded by the HSPA1A gene.

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Locus (genetics)

A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).

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MAP2K6

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17.

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MAP3K7

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene.

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MAPK8IP3

C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene.

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Mitogen-activated protein kinase

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase).

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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P38 mitogen-activated protein kinases

P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.

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PDCD6

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.

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PPP5C

Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.

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Protein kinase R

Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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RB1CC1

RB1-inducible coiled-coil protein 1 is a protein that in humans is encoded by the RB1CC1 gene.

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Thioredoxin

Thioredoxin is a class of small redox proteins known to be present in all organisms.

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TRAF2

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.

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TRAF5

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.

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TRAF6

TRAF6 is a TRAF human protein.

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Unfolded protein response

The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress.

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Redirects here:

ASK-1, Ask1, MAP3K5, MAP3K5 (gene), MAPKKK5, MEKK5, Mapkkk5, Mekk5, Mitogen-activated protein kinase kinase kinase 5.

References

[1] https://en.wikipedia.org/wiki/ASK1

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