103 relations: Adrenaline, Agonist, Agranulocytosis, Akathisia, AkzoNobel, Alanine transaminase, Alpha-1 adrenergic receptor, Alpha-2 adrenergic receptor, Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptor, Alpha-2C adrenergic receptor, Amisulpride, Angioedema, Anticholinergic, Aripiprazole, Atypical antipsychotic, Bipolar disorder, Blood pressure, Bradycardia, Bundle branch block, Burning mouth syndrome, Chlorpromazine, Clinical trial, Clozapine, Confidence interval, CYP1A2, Dopamine, Dopamine receptor D1, Dopamine receptor D2, Dopamine receptor D3, Dopamine receptor D4, Dysarthria, Dysgeusia, Dyskinesia, Dysphagia, Dystonia, European Union, Extrapyramidal symptoms, Feces, Fever, Food and Drug Administration, Galactorrhea, Gynecomastia, Haloperidol, Heart rate, Histamine, Histamine H1 receptor, Histamine H2 receptor, Hyperglycemia, Hyperprolactinaemia, ..., Hyperventilation, Hypoesthesia, Hypotension, Iloperidone, Kidney, Leukopenia, Ligand (biochemistry), Lurasidone, Mianserin, Muscarinic acetylcholine receptor, Neuroleptic malignant syndrome, Neutropenia, New Drug Application, Olanzapine, Organon International, Paliperidone, Paresthesia, Parkinsonism, Perspiration, Pharmaceutical Benefits Scheme, Pharmacodynamics, Phases of clinical research, Post hoc analysis, Pulmonary embolism, QT interval, Quetiapine, Receptor (biochemistry), Receptor antagonist, Rhabdomyolysis, Risperidone, Schering-Plough, Schizophrenia, Serotonin, Sertindole, Somnolence, Statistical hypothesis testing, Statistical significance, Sublingual administration, Syncope (medicine), Tachycardia, Tardive dyskinesia, UGT1A4, United Kingdom, Ziprasidone, Zotepine, 5-HT1A receptor, 5-HT1B receptor, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT5A receptor, 5-HT6 receptor, 5-HT7 receptor. Expand index (53 more) »
Adrenaline
Adrenaline, also known as adrenalin or epinephrine, is a hormone, neurotransmitter, and medication.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Agranulocytosis
Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous leukopenia (lowered white blood cell count), most commonly of neutrophils causing a neutropenia in the circulating blood.
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Akathisia
Akathisia is a movement disorder characterized by a feeling of inner restlessness and inability to stay still.
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AkzoNobel
Akzo Nobel N.V., trading as AkzoNobel, is a Dutch multinational company which creates paints and performance coatings and produces specialty chemicals for both industry and consumers worldwide.
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Alanine transaminase
Alanine transaminase (ALT) is a transaminase enzyme.
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Alpha-1 adrenergic receptor
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
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Alpha-2 adrenergic receptor
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.
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Alpha-2A adrenergic receptor
The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.
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Alpha-2B adrenergic receptor
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor.
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Alpha-2C adrenergic receptor
The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.
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Amisulpride
Amisulpride, sold under the brand name Solian among others, is an antipsychotic medication used to treat schizophrenia.
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Angioedema
Angioedema is an area of swelling of the lower layer of skin and tissue just under the skin or mucous membranes.
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Anticholinergic
An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.
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Aripiprazole
Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. According to a Cochrane review, evidence for the oral form in schizophrenia is not sufficient to determine effects on general functioning. Additionally, because many people dropped out of the medication trials before they were completed, the overall strength of the conclusions is low. Side effects include neuroleptic malignant syndrome, a movement disorder known as tardive dyskinesia, and high blood sugar in those with diabetes. In the elderly there is an increased risk of death. It is thus not recommended for use in those with psychosis due to dementia. It is pregnancy category C in the United States and category C in Australia, meaning there is possible evidence of harm to the fetus. It is not recommended for women who are breastfeeding. It is unclear whether it is safe or effective in people less than 18 years old. It is a partial dopamine agonist. Aripiprazole was developed by Otsuka in Japan. In the United States, Otsuka America markets it jointly with Bristol-Myers Squibb. From April 2013 to March 2014, sales of Abilify amounted to almost $6.9 billion.
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Atypical antipsychotic
The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.
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Bipolar disorder
Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.
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Blood pressure
Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.
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Bradycardia
Bradycardia is a condition wherein an individual has a very slow heart rate, typically defined as a resting heart rate of under 60 beats per minute (BPM) in adults.
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Bundle branch block
A bundle branch block is a defect of the bundle branches or fascicles in the electrical conduction system of the heart.
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Burning mouth syndrome
Burning mouth syndrome (BMS) is a burning sensation in the mouth with no underlying dental or medical cause.
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Chlorpromazine
Chlorpromazine (CPZ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Clozapine
Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication.
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Confidence interval
In statistics, a confidence interval (CI) is a type of interval estimate, computed from the statistics of the observed data, that might contain the true value of an unknown population parameter.
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CYP1A2
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
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Dopamine receptor D1
Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.
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Dopamine receptor D2
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
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Dopamine receptor D3
Dopamine receptor D3 is a protein that in humans is encoded by the DRD3 gene.
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Dopamine receptor D4
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5.
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Dysarthria
Dysarthria is a motor speech disorder resulting from neurological injury of the motor component of the motor-speech system and is characterized by poor articulation of phonemes.
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Dysgeusia
Dysgeusia, also known as parageusia, is a distortion of the sense of taste.
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Dyskinesia
Dyskinesia refers to a category of movement disorders that are characterized by involuntary muscle movements, including movements similar to tics or chorea and diminished voluntary movements.
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Dysphagia
Dysphagia is the medical term for the symptom of difficulty in swallowing.
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Dystonia
Dystonia is a neurological movement disorder syndrome in which sustained or repetitive muscle contractions result in twisting and repetitive movements or abnormal fixed postures.
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European Union
The European Union (EU) is a political and economic union of EUnum member states that are located primarily in Europe.
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Extrapyramidal symptoms
Extrapyramidal symptoms (EPS), also known as extrapyramidal side effects (EPSE), are drug-induced movement disorders that include acute and tardive symptoms.
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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Fever
Fever, also known as pyrexia and febrile response, is defined as having a temperature above the normal range due to an increase in the body's temperature set-point.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Galactorrhea
Galactorrhea (also spelled galactorrhoea) (galacto- + -rrhea) or lactorrhea (lacto- + -rrhea) is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing.
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Gynecomastia
Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.
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Haloperidol
Haloperidol, marketed under the trade name Haldol among others, is a typical antipsychotic medication.
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Heart rate
Heart rate is the speed of the heartbeat measured by the number of contractions of the heart per minute (bpm).
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Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
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Histamine H1 receptor
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
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Histamine H2 receptor
H2 receptors are positively coupled to adenylate cyclase via Gs.
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Hyperglycemia
Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia) is a condition in which an excessive amount of glucose circulates in the blood plasma.
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Hyperprolactinaemia
Hyperprolactinemia or hyperprolactinaemia is the presence of abnormally high levels of prolactin in the blood.
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Hyperventilation
Hyperventilation (a.k.a. overbreathing) occurs when the rate or tidal volume of breathing eliminates more carbon dioxide than the body can produce.
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Hypoesthesia
Hypoesthesia (also spelled as hypesthesia) is a common side effect of various medical conditions which manifests as a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli.
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Hypotension
Hypotension is low blood pressure, especially in the arteries of the systemic circulation.
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Iloperidone
Iloperidone, also known as Fanapt, Fanapta, and previously known as Zomaril, is an atypical antipsychotic for the treatment of schizophrenia.
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Leukopenia
Leukopenia is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Lurasidone
Lurasidone (trade name Latuda) is an atypical antipsychotic developed by Dainippon Sumitomo Pharma and marketed by Sunovion in the U.S. It has been an FDA approved treatment for schizophrenia since 2010 and for treating depressive episodes in adults with bipolar I disorder since 2013.
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Mianserin
Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant which is used in the treatment of depression in Europe and elsewhere in the world.
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Muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.
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Neuroleptic malignant syndrome
Neuroleptic malignant syndrome (NMS) is a life-threatening reaction that occasionally occurs in response to neuroleptic or antipsychotic medication.
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Neutropenia
Neutropenia or neutropaenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood.
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New Drug Application
The Food and Drug Administration's New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing.
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Olanzapine
Olanzapine (originally branded Zyprexa) is an antipsychotic medication used to treat schizophrenia and bipolar disorder.
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Organon International
Organon was a pharmaceutical company headquartered in Oss, Netherlands.
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Paliperidone
Paliperidone, sold under the trade name Invega among others, is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications.
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Paresthesia
Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.
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Parkinsonism
Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia, rigidity, and postural instability.
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Perspiration
Perspiration, also known as sweating, is the production of fluids secreted by the sweat glands in the skin of mammals.
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Pharmaceutical Benefits Scheme
The Pharmaceutical Benefits Scheme (PBS) is a program of the Australian Government that provides subsidised prescription drugs to residents of Australia, as well as certain foreign visitors covered by a Reciprocal Health Care Agreement.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Phases of clinical research
The phases of clinical research are the steps in which scientists do experiments with a health intervention in an attempt to find enough evidence for a process which would be useful as a medical treatment.
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Post hoc analysis
In a scientific study, post hoc analysis (from Latin post hoc, "after this") consists of analyses that were not specified before seeing the data.
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Pulmonary embolism
Pulmonary embolism (PE) is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream (embolism).
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QT interval
In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.
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Quetiapine
Quetiapine, marketed as Seroquel among other names, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Rhabdomyolysis
Rhabdomyolysis is a condition in which damaged skeletal muscle breaks down rapidly.
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Risperidone
Risperidone, sold under the trade name Risperdal among others, is an antipsychotic medication.
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Schering-Plough
Schering-Plough Corporation was a United States-based pharmaceutical company.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Sertindole
Sertindole (brand names: Serdolect and Serlect) is an antipsychotic medication.
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Somnolence
Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
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Statistical hypothesis testing
A statistical hypothesis, sometimes called confirmatory data analysis, is a hypothesis that is testable on the basis of observing a process that is modeled via a set of random variables.
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Statistical significance
In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis.
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Sublingual administration
Sublingual (abbreviated SL), from the Latin for "under the tongue", refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue.
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Syncope (medicine)
Syncope, also known as fainting, is a loss of consciousness and muscle strength characterized by a fast onset, short duration, and spontaneous recovery.
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Tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
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Tardive dyskinesia
Tardive dyskinesia (TD) is a disorder that results in involuntary, repetitive body movements.
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UGT1A4
UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.
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United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.
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Ziprasidone
Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic which is used for the treatment of schizophrenia as well as acute mania and mixed states associated with bipolar disorder.
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Zotepine
Zotepine (brand names: Losizopilon (JP), Lodopin (ID, JP), Setous (JP), Zoleptil (CZ, PT, TR, UK†); where † indicates a formulation that has been discontinued) is an atypical antipsychotic drug indicated for acute and chronic schizophrenia.
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5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT1B receptor
5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene.
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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5-HT2B receptor
5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.
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5-HT2C receptor
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT5A receptor
5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.
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5-HT6 receptor
The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).
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5-HT7 receptor
The 5-HT7 receptor is a member of the GPCR superfamily of cell surface receptors and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) The 5-HT7 receptor is coupled to Gs (stimulates the production of the intracellular signaling molecule cAMP) and is expressed in a variety of human tissues, particularly in the brain, the gastrointestinal tract, and in various blood vessels.
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ATC code N05AH05, ATCvet code QN05AH05, C17H16ClNO, Saphris, Sycrest.
References
[1] https://en.wikipedia.org/wiki/Asenapine