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70 relations: ABL (gene), Acetyltransferase, Adult T-cell leukemia/lymphoma, Apoptosis, Ataxia telangiectasia and Rad3 related, Ataxia-telangiectasia, Biomolecular structure, Bloom syndrome protein, BRCA1, BRCT domain, Cancer, CDC25A, Cell cycle, Cell cycle checkpoint, CHEK2, Chronic lymphocytic leukemia, Cyclin B, Cyclin-dependent kinase 1, Disulfide, DNA methylation, DNA repair, DNA replication, DNA-PKcs, Drosophila melanogaster, Epigenetics, FANCD2, Genetic recombination, H2AFX, HEAT repeat, Huntingtin, Infertility, Initiation, Ionizing radiation, Leukemia, Lymphoma, Mantle cell lymphoma, MDC1, Mdm2, Messenger RNA, MRE11A, MRN complex, MTOR, Mutation, Nibrin, Oocyte, Oxford University Press, P21, P53, Phosphatidylinositol 3-kinase-related kinase, Phosphoinositide 3-kinase, ..., Protein kinase, Protein–protein interaction, RAD17, Rad50, RAD51, RBBP8, RHEB, RRM2B, Serine, SMC1A, Somatic cell, T-cell prolymphocytic leukemia, Telomere, TERF1, Testicle, Threonine, TP53BP1, Transformation/transcription domain-associated protein, Translation (biology), Tumor suppressor. Expand index (20 more) »
ABL (gene)
Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.
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Acetyltransferase
Acetyltransferase (or transacetylase) is a type of transferase enzyme that transfers an acetyl group.
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Adult T-cell leukemia/lymphoma
Adult T-cell leukemia/lymphoma (ATL or ATLL) is a rare cancer of the immune system's own T-cells.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Ataxia telangiectasia and Rad3 related
Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene.
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Ataxia-telangiectasia
Ataxia-telangiectasia (AT or A-T), also referred to as ataxia-telangiectasia syndrome or Louis–Bar syndrome, is a rare, neurodegenerative, autosomal recessive disease causing severe disability.
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Biomolecular structure
Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.
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Bloom syndrome protein
Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is not expressed in Bloom syndrome.
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BRCA1
BRCA1 and BRCA1 are a human gene and its protein product, respectively.
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BRCT domain
BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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CDC25A
M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.
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Cell cycle
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.
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Cell cycle checkpoint
Cell cycle checkpoints are control mechanisms in eukaryotic cells which ensure proper division of the cell.
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CHEK2
CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase.
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Chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).
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Cyclin B
Cyclin B is a member of the cyclin family.
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Cyclin-dependent kinase 1
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation.
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Disulfide
In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′.
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DNA methylation
DNA methylation is a process by which methyl groups are added to the DNA molecule.
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DNA repair
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
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DNA replication
In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.
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DNA-PKcs
DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene designated as PRKDC or XRCC7.
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Drosophila melanogaster
Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.
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Epigenetics
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
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FANCD2
Fanconi anemia group D2 protein is a protein that in humans is encoded by the FANCD2 gene.
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Genetic recombination
Genetic recombination (aka genetic reshuffling) is the production of offspring with combinations of traits that differ from those found in either parent.
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H2AFX
H2AFX (H2A histone family, member X) is one of several genes coding for histone H2A.
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HEAT repeat
A HEAT repeat is tandem repeat protein structural motif composed of two alpha helices linked by a short loop.
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Huntingtin
The huntingtin gene, also called the HTT or HD (Huntington disease) gene, is the IT15 ("interesting transcript 15") gene, which codes for a protein called the huntingtin protein.
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Infertility
Infertility is the inability of a person, animal or plant to reproduce by natural means.
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Initiation
Initiation is a rite of passage marking entrance or acceptance into a group or society.
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Ionizing radiation
Ionizing radiation (ionising radiation) is radiation that carries enough energy to liberate electrons from atoms or molecules, thereby ionizing them.
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Leukemia
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
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Lymphoma
Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).
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Mantle cell lymphoma
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma (NHL), comprising about 6% of NHL cases.
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MDC1
Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene located on the short arm (p) of chromosome 6.
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Mdm2
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene.
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Messenger RNA
Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.
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MRE11A
Double-strand break repair protein MRE11A is a protein that in humans is encoded by the MRE11A gene.
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MRN complex
The MRN complex (MRX complex in yeast) is a protein complex consisting of Mre11, Rad50 and Nbs1 (also known as Nibrin in humans and as Xrs2 in yeast).
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MTOR
The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.
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Mutation
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
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Nibrin
Nibrin, also known as NBN or NBS1, is a protein which in humans is encoded by the NBN gene.
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Oocyte
An oocyte, oöcyte, ovocyte, or rarely ocyte, is a female gametocyte or germ cell involved in reproduction.
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Oxford University Press
Oxford University Press (OUP) is the largest university press in the world, and the second oldest after Cambridge University Press.
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P21
p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2.
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P53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
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Phosphatidylinositol 3-kinase-related kinase
Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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Protein kinase
A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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RAD17
Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene.
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Rad50
DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene.
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RAD51
RAD51 is a eukaryotic gene.
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RBBP8
Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.
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RHEB
RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals.
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RRM2B
Ribonucleoside-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the RRM2B gene.
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Serine
Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.
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SMC1A
Structural maintenance of chromosomes protein 1A is a protein that in humans is encoded by the SMC1A gene.
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Somatic cell
A somatic cell (from the Greek σῶμα sôma, meaning "body") or vegetal cell is any biological cell forming the body of an organism; that is, in a multicellular organism, any cell other than a gamete, germ cell, gametocyte or undifferentiated stem cell.
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T-cell prolymphocytic leukemia
T-cell-prolymphocytic leukemia (T-PLL) is a mature T-cell leukemia with aggressive behavior and predilection for blood, bone marrow, lymph nodes, liver, spleen, and skin involvement.
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Telomere
A telomere is a region of repetitive nucleotide sequences at each end of a chromosome, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes.
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TERF1
Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene.
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Testicle
The testicle or testis is the male reproductive gland in all animals, including humans.
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Threonine
Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins.
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TP53BP1
Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.
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Transformation/transcription domain-associated protein
Transformation/transcription domain-associated protein, also known asTRRAP, is a protein that in humans is encoded by the TRRAP gene.
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Translation (biology)
In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.
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Tumor suppressor
A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.
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Redirects here:
ATM (gene), ATM kinase, ATM protein, Ataxia telangiectasia mutated.
References
[1] https://en.wikipedia.org/wiki/ATM_serine/threonine_kinase
