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12 relations: Agonist, AM-6545, Analgesic, AstraZeneca, Benzimidazole, Blood–brain barrier, Cannabinoid, Cannabinoid receptor type 1, Cannabinoid receptor type 2, CB-13, Partial agonist, WIN 55,212-2.
Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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AM-6545
AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity.
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Analgesic
An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
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AstraZeneca
AstraZeneca plc is an Anglo–Swedish multinational pharmaceutical and biopharmaceutical company.
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Benzimidazole
Benzimidazole is a heterocyclic aromatic organic compound.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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Cannabinoid
A cannabinoid is one of a class of diverse chemical compounds that acts on cannabinoid receptors in cells that alter neurotransmitter release in the brain.
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Cannabinoid receptor type 1
The cannabinoid type 1 receptor, often abbreviated as CB1, is a G protein-coupled cannabinoid receptor located in the central and peripheral nervous system.
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Cannabinoid receptor type 2
The cannabinoid receptor type 2, abbreviated as CB2, is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene.
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CB-13
CB-13 (CRA13, SAB-378) is a cannabinoid drug, which acts as a potent agonist at both the CB1 and CB2 receptors, but has poor blood–brain barrier penetration, and so produces only peripheral effects at low doses, with symptoms of central effects such as catalepsy only appearing at much higher dose ranges.
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Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
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WIN 55,212-2
WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure.
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