25 relations: Antihypertensive drug, Azepindole, Drug, Enzyme inhibitor, Indorenate, International nonproprietary name, Ligand (biochemistry), Metralindole, Monoamine oxidase A, Monoamine oxidase inhibitor, Pargyline, Pirlindole, Receptor (biochemistry), Serotonin, Substituted tryptamine, Sumatriptan, Tetrindole, 5-(Nonyloxy)tryptamine, 5-Benzyloxytryptamine, 5-Carboxamidotryptamine, 5-Ethoxy-DMT, 5-HT receptor, 5-HT1A receptor, 5-HT1D receptor, 5-Methoxytryptamine.
Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure).
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Azepindole (McN-2453) is a tricyclic compound with antidepressant and antihypertensive effects that was developed in the late 1960s but was never marketed.
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A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.
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4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
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Indorenate (TR-3369), is a tryptamine derivative which acts as an agonist at the 5-HT1A, 5-HT1B and 5-HT2C serotonin receptors.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Metralindole (Inkazan) is a reversible inhibitor of monoamine oxidase A (RIMA) which was investigated in Russia as a potential antidepressant.
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Monoamine oxidase A
Monoamine oxidase A, also known as MAO-A, is an enzyme that in humans is encoded by the MAOA gene.
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Monoamine oxidase inhibitor
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).
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Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug (IC50 for MAO-A is 0.01152 µmol/L and for MAO-B is 0.00820 µmol/L) It was brought to market in the US and the UK by Abbott in 1963 as an antihypertensive drug branded "Eutonyl".
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Pirlindole (Lifril, Pyrazidol) is a reversible inhibitor of monoamine oxidase A (RIMA) which was developed and is used in Russia as an antidepressant.
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In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Substituted tryptamines, or serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself.
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Sumatriptan is a medication used for the treatment of migraine and cluster headaches.
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Tetrindole was a drug candidate that functions by reversibly inhibiting monoamine oxidase A; it was first synthesized in Moscow in the early 1990s.
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5-(Nonyloxy)tryptamine is a tryptamine derivative which acts as a selective agonist at the 5-HT1B receptor.
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5-Benzyloxytryptamine (5-BT), is a tryptamine derivative which acts as an agonist at the 5-HT1D, 5-HT2 and 5-HT6 serotonin receptors.
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5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.
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5-Ethoxy-DMT (5-ethoxy-N,N-dimethyltryptamine, 5-EtO-DMT, O-ethylbufotenine) is a tryptamine derivative which has been previously synthesized as a chemical intermediate, but has not been studied to determine its pharmacology.
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5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
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The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.
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5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin.
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5-Acetyl-tryptamine, 5-Acetyltryptamine, 5-acetyl-tryptamine, 5-acetyltryptamine, Acetriptin, Acetriptina, Acetriptine, Acetriptinum, Acetryptin, Acetryptina, Acetryptinum, W 2965-A, W 2965A, W-2965 A, W-2965-A, W-2965A, W2965 A, W2965-A, W2965A.