41 relations: Adenosine, Adenosine A2A receptor, Adenosine receptor, Adenylyl cyclase, Agonist, Arachidonic acid, Bamifylline, Basal forebrain, Bradycardia, Caffeine, Calcium channel, Cardiac arrest, Cardiac muscle, Cardiopulmonary resuscitation, CCPA (biochemistry), CGS-15943, Cholinergic, Cyclic adenosine monophosphate, Diacylglycerol lipase, Diglyceride, Dipropylcyclopentylxanthine, Endogeny (biology), G protein–coupled receptor, Heart rate, Hypotension, Inositol trisphosphate, Intravenous therapy, Ligand, Myocardial infarction, N6-Cyclopentyladenosine, Neonatology, Periventricular leukomalacia, Phospholipase C, Potassium channel, Rolofylline, Shock (circulatory), Sinoatrial node, Synaptic vesicle, Tachycardia, Theophylline, Ventriculomegaly.
Adenosine is both a chemical found in many living systems and a medication.
The adenosine A2A receptor, also known as ADORA2A, is an adenosine receptor, and also denotes the human gene encoding it.
The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as endogenous ligand.
Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).
Bamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A1 receptor antagonist.
The basal forebrain structures are located in the forebrain to the front of and below the striatum.
Bradycardia is a condition wherein an individual has a very slow heart rate, typically defined as a resting heart rate of under 60 beats per minute (BPM) in adults.
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class.
A calcium channel is an ion channel which shows selective permeability to calcium ions.
Cardiac arrest is a sudden loss of blood flow resulting from the failure of the heart to effectively pump.
Cardiac muscle (heart muscle) is one of the three major types of muscle, the others being skeletal and smooth muscle.
Cardiopulmonary resuscitation (CPR) is an emergency procedure that combines chest compressions often with artificial ventilation in an effort to manually preserve intact brain function until further measures are taken to restore spontaneous blood circulation and breathing in a person who is in cardiac arrest.
2-Chloro-N6-cyclopentyladenosine (CCPA) is a specific receptor agonist for the Adenosine A1 receptor.
CGS-15943 is a drug which acts as a potent and reasonably selective antagonist for the adenosine receptors A1 and A2A, having a Ki of 3.3nM at A2A and 21nM at A1.
In general, the word choline refers to the various quaternary ammonium salts containing the ''N'',''N'',''N''-trimethylethanolammonium cation.
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages.
8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948) is a drug which acts as a potent and selective antagonist for the adenosine A1 receptor.
Endogenous substances and processes are those that originate from within an organism, tissue, or cell.
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
Heart rate is the speed of the heartbeat measured by the number of contractions of the heart per minute (bpm).
Hypotension is low blood pressure, especially in the arteries of the systemic circulation.
Inositol trisphosphate or inositol 1,4,5-trisphosphate (also commonly known as triphosphoinositol; abbreviated InsP3 or Ins3P or IP3), together with diacylglycerol (DAG), is a secondary messenger molecule used in signal transduction and lipid signaling in biological cells.
Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
N6-Cyclopentyladenosine (CPA) is a drug which acts as a selective adenosine A1 receptor agonist.
Neonatology is a subspecialty of pediatrics that consists of the medical care of newborn infants, especially the ill or premature newborn.
Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles.
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms.
Rolofylline (KW-3902) is an experimental diuretic which acts as a selective adenosine A1 receptor antagonist.
Shock is the state of low blood perfusion to tissues resulting in cellular injury and inadequate tissue function.
The sinoatrial node (SA node), also known as sinus node, is a group of cells located in the wall of the right atrium of the heart.
In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse.
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
Theophylline, also known as 1,3-dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names.
Ventriculomegaly is a brain condition that occurs in the fetus when the lateral ventricles become dilated.