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Afegostat

Index Afegostat

Afegostat (INN; also known as isofagomine; planned trade name Plicera) was an experimental drug for the treatment of certain forms of Gaucher's disease that was being developed by Amicus Therapeutics and Shire plc until a failed clinical trial in 2009 led to termination of its development. [1]

15 relations: Amicus Therapeutics, Eliglustat, European Medicines Agency, Food and Drug Administration, Gaucher's disease, Glucocerebroside, Imiglucerase, Iminosugar, International nonproprietary name, Miglustat, Mikael Bols, Orphan drug, Protein structure, Shire (pharmaceutical company), Tartrate.

Amicus Therapeutics

Amicus Therapeutics is a public American biopharmaceutical company based in Cranbury, New Jersey.

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Eliglustat

Eliglustat (INN, USAN; trade name Cerdelga) is a treatment for Gaucher's disease developed by Genzyme Corp that was approved by the FDA August 2014.

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European Medicines Agency

The European Medicines Agency (EMA) is a European Union agency for the evaluation of medicinal products.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Gaucher's disease

Gaucher's disease or Gaucher disease (GD) is a genetic disorder in which glucocerebroside (a sphingolipid, also known as glucosylceramide) accumulates in cells and certain organs.

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Glucocerebroside

Glucocerebroside (also called glucosylceramide) is any of the cerebrosides in which the monosaccharide head group is glucose.

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Imiglucerase

Imiglucerase is a medication used in the treatment of Gaucher's disease.

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Iminosugar

An iminosugar, also known as an iminosaccharide, is any analog of a sugar where a nitrogen atom has replaced the oxygen atom in the ring of the structure.

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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Miglustat

Miglustat (OGT 918, N-butyl-deoxynojirimycin) is a drug developed by Oxford GlycoSciences and marketed by Actelion and is used primarily to treat type I Gaucher disease (GD1).

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Mikael Bols

Mikael Bols (born July 28, 1961) is a synthetic organic chemist who is mainly known for his work on carbohydrates and artificial enzymes.

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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.

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Protein structure

Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule.

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Shire (pharmaceutical company)

Shire Plc is a Jersey-registered, Irish-headquartered global specialty biopharmaceutical company.

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Tartrate

A tartrate is a salt or ester of the organic compound tartaric acid, a dicarboxylic acid.

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Redirects here:

Isofagomine, Isofagomine tartrate, Plicera.

References

[1] https://en.wikipedia.org/wiki/Afegostat

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