Table of Contents
61 relations: Acetylcholine, Adrenaline, Adrenergic receptor, Ancient Greek, Aripiprazole, Buprenorphine, Buspirone, Calcium in biology, Cell (biology), Central nervous system, Charge density, Clozapine, Depolarization, Dopamine, Dopamine receptor, Dose–response relationship, EC50, Effective dose (pharmacology), Efficacy, Endogenous agonist, Endogeny (biology), Endorphins, Excitatory postsynaptic potential, Exogeny, Functional selectivity, G protein-coupled receptor, Glutamic acid, Glycine, Hormone, Inositol trisphosphate receptor, Intrinsic activity, Inverse agonist, Ion, Ion channel, Irreversible agonist, Isoprenaline, Ligand (biochemistry), Magnesium, Median toxic dose, Medication, Morphine, Muscarinic acetylcholine receptor, N-Methyl-D-aspartic acid, Neurotransmitter, NMDA receptor, Oliceridine, Opiate, Partial agonist, Physiological agonism and antagonism, Potency (pharmacology), ... Expand index (11 more) »
- Receptor agonists
Acetylcholine
Acetylcholine (ACh) is an organic compound that functions in the brain and body of many types of animals (including humans) as a neurotransmitter.
Adrenaline
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration).
Adrenergic receptor
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β2) agonists and alpha-2 (α2) agonists, which are used to treat high blood pressure and asthma, for example.
See Agonist and Adrenergic receptor
Ancient Greek
Ancient Greek (Ἑλληνῐκή) includes the forms of the Greek language used in ancient Greece and the ancient world from around 1500 BC to 300 BC.
Aripiprazole
Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder; other uses include as an add-on treatment in major depressive disorder and obsessive compulsive disorder (OCD), tic disorders, and irritability associated with autism.
Buprenorphine
Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain.
Buspirone
Buspirone, sold under the brand name Buspar, among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder.
Calcium in biology
Calcium ions (Ca2+) contribute to the physiology and biochemistry of organisms' cells.
See Agonist and Calcium in biology
Cell (biology)
The cell is the basic structural and functional unit of all forms of life.
See Agonist and Cell (biology)
Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.
See Agonist and Central nervous system
Charge density
In electromagnetism, charge density is the amount of electric charge per unit length, surface area, or volume.
See Agonist and Charge density
Clozapine
Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered.
Depolarization
In biology, depolarization or hypopolarization is a change within a cell, during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell compared to the outside.
See Agonist and Depolarization
Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells.
Dopamine receptor
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS).
See Agonist and Dopamine receptor
Dose–response relationship
The dose–response relationship, or exposure–response relationship, describes the magnitude of the response of an organism, as a function of exposure (or doses) to a stimulus or stressor (usually a chemical) after a certain exposure time. Agonist and dose–response relationship are Pharmacodynamics.
See Agonist and Dose–response relationship
EC50
Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. Agonist and EC50 are Pharmacodynamics.
See Agonist and EC50
Effective dose (pharmacology)
In pharmacology, an effective dose (ED) or effective concentration (EC) is the dose or concentration of a drug that produces a biological response.
See Agonist and Effective dose (pharmacology)
Efficacy
Efficacy is the ability to perform a task to a satisfactory or expected degree. Agonist and Efficacy are medical terminology and Pharmacodynamics.
Endogenous agonist
In pharmacology, an endogenous agonist for a particular receptor is a compound naturally produced by the body which binds to and activates that receptor. Agonist and endogenous agonist are medical terminology, medicinal chemistry, Pharmacodynamics, physiology and receptor agonists.
See Agonist and Endogenous agonist
Endogeny (biology)
Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.
See Agonist and Endogeny (biology)
Endorphins
Endorphins (contracted from endogenous morphine) are peptides produced in the brain that block the perception of pain and increase feelings of wellbeing.
Excitatory postsynaptic potential
In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential.
See Agonist and Excitatory postsynaptic potential
Exogeny
In a variety of contexts, exogeny or exogeneity is the fact of an action or object originating externally.
Functional selectivity
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signaling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor. Agonist and Functional selectivity are Pharmacodynamics.
See Agonist and Functional selectivity
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses.
See Agonist and G protein-coupled receptor
Glutamic acid
Glutamic acid (symbol Glu or E; the anionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins.
Glycine
Glycine (symbol Gly or G) is an amino acid that has a single hydrogen atom as its side chain.
Hormone
A hormone (from the Greek participle ὁρμῶν, "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs or tissues by complex biological processes to regulate physiology and behavior. Agonist and hormone are physiology.
Inositol trisphosphate receptor
Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3).
See Agonist and Inositol trisphosphate receptor
Intrinsic activity
Intrinsic activity (IA) and efficacy refer to the relative ability of a drug-receptor complex to produce a maximum functional response. Agonist and Intrinsic activity are Pharmacodynamics.
See Agonist and Intrinsic activity
Inverse agonist
In pharmacology, an inverse agonist is a drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist. Agonist and inverse agonist are Pharmacodynamics and receptor agonists.
See Agonist and Inverse agonist
Ion
An ion is an atom or molecule with a net electrical charge.
See Agonist and Ion
Ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.
Irreversible agonist
An irreversible agonist is a type of agonist that binds permanently to a receptor in such a manner that the receptor is permanently activated. Agonist and irreversible agonist are receptor agonists.
See Agonist and Irreversible agonist
Isoprenaline
Isoprenaline, or isoproterenol, is a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma.
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
See Agonist and Ligand (biochemistry)
Magnesium
Magnesium is a chemical element; it has symbol Mg and atomic number 12.
Median toxic dose
In toxicology, the median toxic dose (TD50) of a drug or toxin is the dose at which toxicity occurs in 50% of cases.
See Agonist and Median toxic dose
Medication
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
Morphine
Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum).
Muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.
See Agonist and Muscarinic acetylcholine receptor
N-Methyl-D-aspartic acid
N-methyl--aspartic acid or N-methyl--aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.
See Agonist and N-Methyl-D-aspartic acid
Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.
See Agonist and Neurotransmitter
NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons.
Oliceridine
Oliceridine, sold under the brand name Olinvyk, is an opioid medication that is used for the treatment of moderate to severe acute pain in adults.
Opiate
An opiate is an alkaloid substance derived from opium (or poppy straw).
Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. Agonist and partial agonist are Pharmacodynamics.
See Agonist and Partial agonist
Physiological agonism and antagonism
Physiological agonism describes the action of a substance which ultimately produces the same effects in the body as another substance—as if they were both agonists at the same receptor—without actually binding to the same receptor. Agonist and Physiological agonism and antagonism are medical terminology, Pharmacodynamics, physiology and receptor agonists.
See Agonist and Physiological agonism and antagonism
Potency (pharmacology)
In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. Agonist and potency (pharmacology) are Pharmacodynamics.
See Agonist and Potency (pharmacology)
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.
Protein folding
Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random coil into a more ordered three-dimensional structure.
See Agonist and Protein folding
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.
See Agonist and Receptor (biochemistry)
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Agonist and receptor antagonist are Pharmacodynamics.
See Agonist and Receptor antagonist
Receptor theory
Receptor theory is the application of receptor models to explain drug behavior.
See Agonist and Receptor theory
Rimonabant
Rimonabant (also known as SR141716; trade names Acomplia, Zimulti) is an anorectic antiobesity drug approved in Europe in 2006 but was withdrawn worldwide in 2008 due to serious psychiatric side effects; it was never approved in the United States.
Selective receptor modulator
In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues. Agonist and selective receptor modulator are Pharmacodynamics.
See Agonist and Selective receptor modulator
Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
Superagonist
In the field of pharmacology, a superagonist is a type of agonist that is capable of producing a maximal response greater than the endogenous agonist for the target receptor, and thus has an efficacy of more than 100%. Agonist and superagonist are receptor agonists.
Therapeutic index
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug.
See Agonist and Therapeutic index
5-HT receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
See also
Receptor agonists
- Acifran
- Adrenergic receptor agonists
- Agonist
- Calcimimetic
- Cannabinoid receptor agonists
- Cholesterol
- Cholinergics
- DA-1241
- Dopamine agonists
- Endogenous agonist
- Estrogens
- Histamine agonists
- Inverse agonist
- Irreversible agonist
- LBT-3627
- Lipomannan
- Melatonin receptor agonists
- Orexin receptor agonists
- Oxytocin receptor agonists
- PL-3994
- Physiological agonism and antagonism
- Polydiscamide B
- Progestogens
- Purmorphamine
- Recombinant human parathyroid hormone
- Serotonin receptor agonists
- Smoothened agonist
- Superagonist
- TAAR1 agonists
- Tavilermide
- Thrombopoietin receptor agonists
- Zelatriazin
References
Also known as Agonistic, Agonistics, Agonists, Co-agonist, Coagonist, Competitive agonist, Direct agonist, Full agonist, Full agonists, Functional activity, Partial agonists, Receptor agonism, Receptor agonist, Receptor agonists, Selective agonist, Superagonistic.