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Allopregnanolone

Index Allopregnanolone

Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone. [1]

Table of Contents

  1. 164 relations: Aggression, Agonist, Alcoholism, Aldo-keto reductase, Alfadolone, Alfaxalone, Allosteric modulator, Alprazolam, Altered state of consciousness, AMPA receptor, Analgesic, Androgen backdoor pathway, Anesthesia, Anesthetic, Anticonvulsant, Antidepressant, Antigonadotropin, Anxiety, Anxiolytic, Aphrodisiac, Aqueous solution, Basolateral amygdala, Benzodiazepine, Bioavailability, Bioconjugation, Biological activity, Biological half-life, Biological target, Biosynthesis, Blood plasma, Breakthrough therapy, Catamenial epilepsy, Cav1.2, Cav1.3, Channel blocker, Citric acid, Clearance (pharmacology), Cognitive impairment, Concentration, Controlled substance, Corticotropin-releasing hormone, Cyclodextrin, Cytochrome P450, DailyMed, Depression (mood), Derivative (chemistry), Dihydrotestosterone, Endogeny (biology), Epilepsy, Epipregnanolone, ... Expand index (114 more) »

  2. 5α-Pregnanes
  3. Acetyl compounds
  4. GABAA-rho receptor positive allosteric modulators
  5. Pregnane X receptor agonists

Aggression

Aggression is a behavior aimed at opposing or attacking something or someone.

See Allopregnanolone and Aggression

Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

See Allopregnanolone and Agonist

Alcoholism

Alcoholism is the continued drinking of alcohol despite it causing problems.

See Allopregnanolone and Alcoholism

Aldo-keto reductase

The aldo-keto reductase family is a family of proteins that are subdivided into 16 categories; these include a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase, xylose reductase, rho crystallin, and many others.

See Allopregnanolone and Aldo-keto reductase

Alfadolone

Alfadolone (INN), or alphadolone is a neuroactive steroid and general anesthetic. Allopregnanolone and Alfadolone are GABAA receptor positive allosteric modulators, neurosteroids and pregnanes.

See Allopregnanolone and Alfadolone

Alfaxalone

Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic. Allopregnanolone and Alfaxalone are GABAA receptor positive allosteric modulators, GABAA-rho receptor positive allosteric modulators, glycine receptor agonists, neurosteroids, pregnanes and Sterols.

See Allopregnanolone and Alfaxalone

Allosteric modulator

In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli.

See Allopregnanolone and Allosteric modulator

Alprazolam

Alprazolam, sold under the brand name Xanax and others, is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines. Allopregnanolone and Alprazolam are GABAA receptor positive allosteric modulators.

See Allopregnanolone and Alprazolam

Altered state of consciousness

An altered state of consciousness (ASC), also called an altered state of mind, altered mental status (AMS) or mind alteration, is any condition which is significantly different from a normal waking state.

See Allopregnanolone and Altered state of consciousness

AMPA receptor

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate (iGluR) and predominantly Na+ ion channel that mediates fast synaptic transmission in the central nervous system (CNS).

See Allopregnanolone and AMPA receptor

Analgesic

An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.

See Allopregnanolone and Analgesic

Androgen backdoor pathway

The androgen backdoor pathway is responsible for the synthesis of physiologically relevant androgens.

See Allopregnanolone and Androgen backdoor pathway

Anesthesia

Anesthesia or anaesthesia is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes.

See Allopregnanolone and Anesthesia

Anesthetic

An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia ⁠— ⁠in other words, to result in a temporary loss of sensation or awareness.

See Allopregnanolone and Anesthetic

Anticonvulsant

Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Allopregnanolone and Anticonvulsant are Anticonvulsants.

See Allopregnanolone and Anticonvulsant

Antidepressant

Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction. Allopregnanolone and Antidepressant are Antidepressants.

See Allopregnanolone and Antidepressant

Antigonadotropin

An antigonadotropin is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

See Allopregnanolone and Antigonadotropin

Anxiety

Anxiety is an emotion which is characterised by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events.

See Allopregnanolone and Anxiety

Anxiolytic

An anxiolytic (also antipanic or anti-anxiety agent) is a medication or other intervention that reduces anxiety.

See Allopregnanolone and Anxiolytic

Aphrodisiac

An aphrodisiac is a substance alleged to increase libido, sexual desire, sexual attraction, sexual pleasure, or sexual behavior.

See Allopregnanolone and Aphrodisiac

Aqueous solution

An aqueous solution is a solution in which the solvent is water.

See Allopregnanolone and Aqueous solution

Basolateral amygdala

The basolateral amygdala, or basolateral complex, consists of the lateral, basal and accessory-basal nuclei of the amygdala.

See Allopregnanolone and Basolateral amygdala

Benzodiazepine

Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.

See Allopregnanolone and Benzodiazepine

Bioavailability

In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.

See Allopregnanolone and Bioavailability

Bioconjugation

Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule.

See Allopregnanolone and Bioconjugation

Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

See Allopregnanolone and Biological activity

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

See Allopregnanolone and Biological half-life

Biological target

A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.

See Allopregnanolone and Biological target

Biosynthesis

Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

See Allopregnanolone and Biosynthesis

Blood plasma

Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.

See Allopregnanolone and Blood plasma

Breakthrough therapy

Breakthrough therapy is a United States Food and Drug Administration designation that expedites drug development that was created by Congress under Section 902 of the 9 July 2012 Food and Drug Administration Safety and Innovation Act.

See Allopregnanolone and Breakthrough therapy

Catamenial epilepsy

Catamenial epilepsy is a form of epilepsy in women where seizures are exacerbated during certain phases of the menstrual cycle.

See Allopregnanolone and Catamenial epilepsy

Cav1.2

Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Cav1.2) is a protein that in humans is encoded by the CACNA1C gene.

See Allopregnanolone and Cav1.2

Cav1.3

Calcium channel, voltage-dependent, L type, alpha 1D subunit (also known as Cav1.3) is a protein that in humans is encoded by the CACNA1D gene.

See Allopregnanolone and Cav1.3

Channel blocker

A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell.

See Allopregnanolone and Channel blocker

Citric acid

Citric acid is an organic compound with the chemical formula.

See Allopregnanolone and Citric acid

Clearance (pharmacology)

In pharmacology, clearance (Cl_) is a pharmacokinetic parameter representing the efficiency of drug elimination.

See Allopregnanolone and Clearance (pharmacology)

Cognitive impairment

Cognitive impairment is an inclusive term to describe any characteristic that acts as a barrier to the cognition process or different areas of cognition.

See Allopregnanolone and Cognitive impairment

Concentration

In chemistry, concentration is the abundance of a constituent divided by the total volume of a mixture.

See Allopregnanolone and Concentration

Controlled substance

A controlled substance is generally a drug or chemical whose manufacture, possession and use is regulated by a government, such as illicitly used drugs or prescription medications that are designated by law.

See Allopregnanolone and Controlled substance

Corticotropin-releasing hormone

Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress responses.

See Allopregnanolone and Corticotropin-releasing hormone

Cyclodextrin

Cyclodextrins are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits joined by α-1,4 glycosidic bonds.

See Allopregnanolone and Cyclodextrin

Cytochrome P450

Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases.

See Allopregnanolone and Cytochrome P450

DailyMed

DailyMed is a website operated by the U.S. National Library of Medicine (NLM) to publish up-to-date and accurate drug labels (also called a "package insert") to health care providers and the general public.

See Allopregnanolone and DailyMed

Depression (mood)

Depression is a mental state of low mood and aversion to activity.

See Allopregnanolone and Depression (mood)

Derivative (chemistry)

In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.

See Allopregnanolone and Derivative (chemistry)

Dihydrotestosterone

Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved in the growth and repair of the prostate and the penis, as well as the production of sebum and body hair composition. Allopregnanolone and Dihydrotestosterone are GABAA receptor positive allosteric modulators.

See Allopregnanolone and Dihydrotestosterone

Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

See Allopregnanolone and Endogeny (biology)

Epilepsy

Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures.

See Allopregnanolone and Epilepsy

Epipregnanolone

Epipregnanolone, also known as 3β-hydroxy-5β-pregnan-20-one, 3β,5β-tetrahydroprogesterone, or 3β,5β-THP, is an endogenous neurosteroid. Allopregnanolone and Epipregnanolone are neurosteroids and pregnanes.

See Allopregnanolone and Epipregnanolone

Essential tremor

Essential tremor (ET), also called benign tremor, familial tremor, and idiopathic tremor, is a medical condition characterized by involuntary rhythmic contractions and relaxations (oscillations or twitching movements) of certain muscle groups in one or more body parts of unknown cause.

See Allopregnanolone and Essential tremor

Euphoria

Euphoria is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness.

See Allopregnanolone and Euphoria

Excretion

Excretion is elimination of metabolic waste, which is an essential process in all organisms.

See Allopregnanolone and Excretion

Exogeny

In a variety of contexts, exogeny or exogeneity is the fact of an action or object originating externally.

See Allopregnanolone and Exogeny

Feces

Feces (or faeces;: faex) are the solid or semi-solid remains of food that was not digested in the small intestine, and has been broken down by bacteria in the large intestine.

See Allopregnanolone and Feces

Fetus

A fetus or foetus (fetuses, foetuses, rarely feti or foeti) is the unborn offspring that develops from a mammal embryo.

See Allopregnanolone and Fetus

First-in-class medication

A first-in-class medication is a prototype drug that uses a "new and unique mechanism of action" to treat a particular medical condition.

See Allopregnanolone and First-in-class medication

Flushing (physiology)

Flushing is to become markedly red in the face and often other areas of the skin, from various physiological conditions.

See Allopregnanolone and Flushing (physiology)

Food and Drug Administration

The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.

See Allopregnanolone and Food and Drug Administration

G protein-coupled bile acid receptor

The G protein-coupled bile acid receptor 1 (GPBAR1) also known as G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) is a protein that in humans is encoded by the GPBAR1 gene.

See Allopregnanolone and G protein-coupled bile acid receptor

GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

See Allopregnanolone and GABAA receptor

GABAA-rho receptor

The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits.

See Allopregnanolone and GABAA-rho receptor

GABRD

Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.

See Allopregnanolone and GABRD

Ganaxolone

Ganaxolone, sold under the brand name Ztalmy, is a medication used to treat seizures in people with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder. Allopregnanolone and Ganaxolone are Anticonvulsants, GABAA receptor positive allosteric modulators, neurosteroids, pregnanes and Sterols.

See Allopregnanolone and Ganaxolone

Glucuronidation

Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

See Allopregnanolone and Glucuronidation

Glucuronosyltransferase

Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule.

See Allopregnanolone and Glucuronosyltransferase

Glycine receptor

The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine.

See Allopregnanolone and Glycine receptor

Hamilton Rating Scale for Depression

The Hamilton Rating Scale for Depression (HRSD), also called the Hamilton Depression Rating Scale (HDRS), sometimes also abbreviated as HAM-D, is a multiple-item questionnaire used to provide an indication of depression, and as a guide to evaluate recovery.

See Allopregnanolone and Hamilton Rating Scale for Depression

Hippocampus

The hippocampus (hippocampi; via Latin from Greek ἱππόκαμπος, 'seahorse') is a major component of the brain of humans and other vertebrates.

See Allopregnanolone and Hippocampus

Hormone

A hormone (from the Greek participle ὁρμῶν, "setting in motion") is a class of signaling molecules in multicellular organisms that are sent to distant organs or tissues by complex biological processes to regulate physiology and behavior.

See Allopregnanolone and Hormone

Hot flash

Hot flashes (also known as hot flushes) are a form of flushing, often caused by the changing hormone levels that are characteristic of menopause.

See Allopregnanolone and Hot flash

Hydroxydione

Hydroxydione, as hydroxydione sodium succinate (brand names Viadril, Predion, and Presuren), also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients. Allopregnanolone and hydroxydione are GABAA receptor positive allosteric modulators and neurosteroids.

See Allopregnanolone and Hydroxydione

Hypnotic

Hypnotic (from Greek Hypnos, sleep), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep (or surgical anesthesiaWhen used in anesthesia to produce and maintain unconsciousness, "sleep" is metaphorical as there are no regular sleep stages or cyclical natural states; patients rarely recover from anesthesia feeling refreshed and with renewed energy.

See Allopregnanolone and Hypnotic

Infusion therapy

In medicine, infusion therapy deals with all aspects of fluid and medication infusion, via intravenous or subcutaneous application.

See Allopregnanolone and Infusion therapy

Inhibitory postsynaptic potential

An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential.

See Allopregnanolone and Inhibitory postsynaptic potential

Insomnia

Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

See Allopregnanolone and Insomnia

International nonproprietary name

An international nonproprietary name (INN) is an official generic and nonproprietary name given to a pharmaceutical drug or an active ingredient.

See Allopregnanolone and International nonproprietary name

Intravenous therapy

Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.

See Allopregnanolone and Intravenous therapy

Irritability

Irritability is the excitatory ability that living organisms have to respond to changes in their environment.

See Allopregnanolone and Irritability

Isopregnanolone

Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone, and as 3β-hydroxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone. Allopregnanolone and Isopregnanolone are neurosteroids and pregnanes.

See Allopregnanolone and Isopregnanolone

Kainate receptor

Kainate receptors, or kainic acid receptors (KARs), are ionotropic receptors that respond to the neurotransmitter glutamate.

See Allopregnanolone and Kainate receptor

Ketone

In organic chemistry, a ketone is an organic compound with the structure, where R and R' can be a variety of carbon-containing substituents.

See Allopregnanolone and Ketone

L-type calcium channel

The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel.

See Allopregnanolone and L-type calcium channel

Ligand-gated ion channel

Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.

See Allopregnanolone and Ligand-gated ion channel

Luteal phase

The menstrual cycle is on average 28 days in length.

See Allopregnanolone and Luteal phase

Major depressive disorder

Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities.

See Allopregnanolone and Major depressive disorder

Membrane progesterone receptor

Membrane progesterone receptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR) family which bind the endogenous progestogen and neurosteroid progesterone, as well as the neurosteroid allopregnanolone. Allopregnanolone and membrane progesterone receptor are progestogens.

See Allopregnanolone and Membrane progesterone receptor

Metabolic intermediate

Metabolic intermediates are molecules that are the precursors or metabolites of biologically significant molecules.

See Allopregnanolone and Metabolic intermediate

Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.

See Allopregnanolone and Metabolism

Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

See Allopregnanolone and Metabolite

Minaxolone

Minaxolone (CCI-12923) is a neuroactive steroid which was developed as a general anesthetic but was withdrawn before registration due to toxicity seen with long-term administration in rats, and hence was never marketed. Allopregnanolone and Minaxolone are GABAA receptor positive allosteric modulators, glycine receptor agonists, neurosteroids and pregnanes.

See Allopregnanolone and Minaxolone

Mixture

A mixture is a material made up of two or more different chemical substances which can be separated by physical method.

See Allopregnanolone and Mixture

Natural product

A natural product is a natural compound or substance produced by a living organism—that is, found in nature.

See Allopregnanolone and Natural product

Nervous system

In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body.

See Allopregnanolone and Nervous system

Neuroprotection

Neuroprotection refers to the relative preservation of neuronal structure and/or function.

See Allopregnanolone and Neuroprotection

Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Allopregnanolone and Neurosteroid are neurosteroids.

See Allopregnanolone and Neurosteroid

Neurotransmitter

A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.

See Allopregnanolone and Neurotransmitter

Nicotinic acetylcholine receptor

Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine.

See Allopregnanolone and Nicotinic acetylcholine receptor

NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons.

See Allopregnanolone and NMDA receptor

NPR

National Public Radio (NPR, stylized as npr) is an American public broadcasting organization headquartered in Washington, D.C., with its NPR West headquarters in Culver City, California.

See Allopregnanolone and NPR

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules.

See Allopregnanolone and Nuclear receptor

Oral administration

| name.

See Allopregnanolone and Oral administration

ORG-20599

ORG-20599 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator and, at higher concentrations, agonist. Allopregnanolone and ORG-20599 are Anticonvulsants, GABAA receptor positive allosteric modulators, glycine receptor agonists and neurosteroids.

See Allopregnanolone and ORG-20599

ORG-21465

ORG-21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator. Allopregnanolone and ORG-21465 are Anticonvulsants, GABAA receptor positive allosteric modulators, neurosteroids and pregnanes.

See Allopregnanolone and ORG-21465

Organic compound

Some chemical authorities define an organic compound as a chemical compound that contains a carbon–hydrogen or carbon–carbon bond; others consider an organic compound to be any chemical compound that contains carbon.

See Allopregnanolone and Organic compound

PAQR6

Membrane progesterone receptor delta (mPRδ), or progestin and adipoQ receptor 6 (PAQR6), is a protein that in humans is encoded by the PAQR6 gene.

See Allopregnanolone and PAQR6

PAQR7

Membrane progesterone receptor alpha (mPRα), or progestin and adipoQ receptor 7 (PAQR7), is a protein that in humans is encoded by the PAQR7 gene.

See Allopregnanolone and PAQR7

PAQR8

Membrane progesterone receptor beta (mPRβ), or progestin and adipoQ receptor 8 (PAQR8), is a protein that in humans is encoded by the PAQR8 gene.

See Allopregnanolone and PAQR8

Plasma protein binding

Plasma protein binding refers to the degree to which medications attach to blood proteins within the blood plasma.

See Allopregnanolone and Plasma protein binding

Pleasure

Pleasure is experience that feels good, that involves the enjoyment of something.

See Allopregnanolone and Pleasure

Post-traumatic stress disorder

Post-traumatic stress disorder (PTSD) is a mental and behavioral disorder that develops from experiencing a traumatic event, such as sexual assault, warfare, traffic collisions, child abuse, domestic violence, or other threats on a person's life or well-being.

See Allopregnanolone and Post-traumatic stress disorder

Postpartum depression

Postpartum depression (PPD), also called postnatal depression, is a mood disorder experienced after childbirth, which can affect men and women.

See Allopregnanolone and Postpartum depression

Pregnancy

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb).

See Allopregnanolone and Pregnancy

Pregnane

Pregnane, also known as 17β-ethylandrostane or as 10β,13β-dimethyl-17β-ethylgonane, is a C21 steroid and, indirectly, a parent of progesterone. Allopregnanolone and Pregnane are pregnanes.

See Allopregnanolone and Pregnane

Pregnane X receptor

In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1, group I, member 2) gene.

See Allopregnanolone and Pregnane X receptor

Pregnanediol

Pregnanediol, or 5β-pregnane-3α,20α-diol, is an inactive metabolic product of progesterone.

See Allopregnanolone and Pregnanediol

Pregnanedione

Pregnanedione, or pregnane-3,20-dione, may refer to. Allopregnanolone and Pregnanedione are pregnanes.

See Allopregnanolone and Pregnanedione

Pregnanolone

Pregnanolone, also known as eltanolone, is an endogenous inhibitory neurosteroid which is produced in the body from progesterone. Allopregnanolone and Pregnanolone are GABAA receptor positive allosteric modulators, neurosteroids and pregnane X receptor agonists.

See Allopregnanolone and Pregnanolone

Pregnanolone (disambiguation)

Pregnanolone, also known as tetrahydroprogesterone (THP), may refer to. Allopregnanolone and Pregnanolone (disambiguation) are pregnanes.

See Allopregnanolone and Pregnanolone (disambiguation)

Pregnenolone

Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. Allopregnanolone and Pregnenolone are glycine receptor agonists, neurosteroids, pregnane X receptor agonists, pregnanes and Sterols.

See Allopregnanolone and Pregnenolone

Pregnenolone sulfate

Pregnenolone sulfate (PS, PREGS) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone. Allopregnanolone and pregnenolone sulfate are neurosteroids and pregnanes.

See Allopregnanolone and Pregnenolone sulfate

Premenstrual syndrome

Premenstrual syndrome (PMS) is a disruptive set of emotional and physical symptoms that regularly occur in the one to two weeks before the start of each menstrual period.

See Allopregnanolone and Premenstrual syndrome

Priority review

Priority review is a program of the United States Food and Drug Administration (FDA) to expedite the review process for drugs that are expected to have a particularly great impact on the treatment of a disease.

See Allopregnanolone and Priority review

Prodrug

A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug.

See Allopregnanolone and Prodrug

Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Allopregnanolone and Progesterone are GABAA receptor positive allosteric modulators, neurosteroids, pregnane X receptor agonists, pregnanes and progestogens.

See Allopregnanolone and Progesterone

Progesterone (medication)

Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. Allopregnanolone and Progesterone (medication) are Anticonvulsants, GABAA receptor positive allosteric modulators, neurosteroids, Nicotinic antagonists, pregnane X receptor agonists, pregnanes and progestogens.

See Allopregnanolone and Progesterone (medication)

Progesterone receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. Allopregnanolone and progesterone receptor are progestogens.

See Allopregnanolone and Progesterone receptor

Progestogen

Progestogens, also sometimes written progestins, progestagens or gestagens, are a class of natural or synthetic steroid hormones that bind to and activate the progesterone receptors (PR). Allopregnanolone and Progestogen are progestogens.

See Allopregnanolone and Progestogen

Prosocial behavior

Prosocial behavior, or intent to benefit others, is a social behavior that "benefit other people or society as a whole", "such as helping, sharing, donating, co-operating, and volunteering".

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Psychological stress

In psychology, stress is a feeling of emotional strain and pressure.

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Pyramidal cell

Pyramidal cells, or pyramidal neurons, are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala.

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Redox

Redox (reduction–oxidation or oxidation–reduction) is a type of chemical reaction in which the oxidation states of the reactants change.

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Renanolone

Renanolone (INN), or 11-ketopregnanolone, also known as 5β-pregnan-3α-ol-11,20-dione, is a synthetic neuroactive steroid which is described as a general anesthetic but was never introduced for clinical use. Allopregnanolone and Renanolone are GABAA receptor positive allosteric modulators and neurosteroids.

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Route of administration

In pharmacology and toxicology, a route of administration is the way by which a drug, fluid, poison, or other substance is taken into the body.

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Sedation

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.

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Serenic

A serenic, or antiaggressive agent, is a type of drug which reduces the capacity for irritability and aggression.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is unintended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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Sodium chloride

Sodium chloride, commonly known as edible salt, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chlorine ions.

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Sodium citrate

Sodium citrate may refer to any of the sodium salts of citric acid (though most commonly the third).

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Solubility

In chemistry, solubility is the ability of a substance, the solute, to form a solution with another substance, the solvent.

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Somnolence

Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).

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Status epilepticus

Status epilepticus (SE), or status seizure, is a medical condition consisting of a single seizure lasting more than 5 minutes, or 2 or more seizures within a 5-minute period without the person returning to normal between them.

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Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

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Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

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Sulfation

Sulfation is the chemical reaction that entails the addition of SO3 group.

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Sulfotransferase

In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group from a donor molecule to an acceptor alcohol or amine.

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Syncope (medicine)

Syncope, commonly known as fainting or passing out, is a loss of consciousness and muscle strength characterized by a fast onset, short duration, and spontaneous recovery.

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T-type calcium channel

T-type calcium channels are low voltage activated calcium channels that become inactivated during cell membrane hyperpolarization but then open to depolarization.

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Tetrahydrodeoxycorticosterone

Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. Allopregnanolone and Tetrahydrodeoxycorticosterone are Anticonvulsants, GABAA receptor positive allosteric modulators, neurosteroids and pregnanes.

See Allopregnanolone and Tetrahydrodeoxycorticosterone

Tonicity

In chemical biology, tonicity is a measure of the effective osmotic pressure gradient; the water potential of two solutions separated by a partially-permeable cell membrane.

See Allopregnanolone and Tonicity

Traumatic brain injury

A traumatic brain injury (TBI), also known as an intracranial injury, is an injury to the brain caused by an external force.

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Unconsciousness

Unconsciousness is a state in which a living individual exhibits a complete, or near-complete, inability to maintain an awareness of self and environment or to respond to any human or environmental stimulus.

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United States Adopted Name

A United States Adopted Name (USAN) is a unique nonproprietary name assigned to a medication marketed in the United States.

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Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

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Vial

A vial (also known as a phial or flacon) is a small glass or plastic vessel or bottle, often used to store medication in the form of liquids, powders, or capsules.

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Virilization

Virilization or masculinization is the biological development of adult male characteristics in young males or females.

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Volume of distribution

In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution, literally, volume of dilution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.

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Water for injection

Water for injection is water of extra high quality without significant contamination.

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Xerostomia

Xerostomia, also known as dry mouth, is a subjective complaint of dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.

See Allopregnanolone and Xerostomia

3α-Hydroxysteroid dehydrogenase

3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme (1.1.1.50) that plays a role in the metabolism of steroids and non-steroidal compounds in humans and other species, such as bacteria, fungi, plants, and so on.

See Allopregnanolone and 3α-Hydroxysteroid dehydrogenase

3β-Dihydroprogesterone

3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone, or pregn-4-en-3β-ol-20-one (4-pregnenolone, δ4-pregnenolone), is an endogenous steroid. Allopregnanolone and 3β-Dihydroprogesterone are pregnanes, progestogens and Sterols.

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5-HT3 receptor

The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors.

See Allopregnanolone and 5-HT3 receptor

5α-Dihydroprogesterone

5α-Dihydroprogesterone (5α-DHP, allopregnanedione, or 5α-pregnane-3,20-dione) is an endogenous progestogen and neurosteroid that is synthesized from progesterone. Allopregnanolone and 5α-Dihydroprogesterone are 5α-Pregnanes, GABAA receptor positive allosteric modulators, neurosteroids, pregnane X receptor agonists, pregnanes and progestogens.

See Allopregnanolone and 5α-Dihydroprogesterone

5α-Reductase

5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.

See Allopregnanolone and 5α-Reductase

See also

5α-Pregnanes

Acetyl compounds

GABAA-rho receptor positive allosteric modulators

Pregnane X receptor agonists

References

[1] https://en.wikipedia.org/wiki/Allopregnanolone

Also known as 3beta-hydroxy-5alpha-pregnane-20-one, 3α,5α-tetrahydroprogesterone, Allopregnanolone (drug), Allopregnanolone (medication), BRII-296, Brexanolone, SAGE 547, SAGE-547, SAGE547, SGE 102, SGE-102, SGE102, Zulresso.

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