Table of Contents
52 relations: Agonist, Alcohol (drug), Allosteric regulation, Alprazolam, AMPA receptor, AMPA receptor positive allosteric modulator, Aniracetam, Barbiturate, Benzodiazepine, Biochemistry, Calcium-sensing receptor, CCR5, Chemical specificity, Chlordiazepoxide, Cinacalcet, Concentration, Conformational isomerism, CX614, Cyclothiazide, Desensitization (medicine), Diazepam, Dipraglurant, Dopamine receptor D1, Dose–response relationship, Drug overdose, Evolution, Fenobam, GABAA receptor, GABAA receptor negative allosteric modulator, GABAA receptor positive allosteric modulator, Glutamic acid, Intrinsic activity, Ion channel, Ligand (biochemistry), Major depressive disorder, Maraviroc, Metabotropic glutamate receptor 5, Mevidalen, Mutation, Neurotransmitter, Nicotinic acetylcholine receptor, Partial agonist, PH, Pharmacology, Phenobarbital, Psychoactive drug, Raseglurant, Receptor (biochemistry), Receptor antagonist, Research chemical, ... Expand index (2 more) »
- Neuropharmacology
Agonist
An agonist is a chemical that activates a receptor to produce a biological response.
See Allosteric modulator and Agonist
Alcohol (drug)
Alcohol, sometimes referred to by the chemical name ethanol, is one of the most widely used and abused psychoactive drugs in the world and falls under the depressant category.
See Allosteric modulator and Alcohol (drug)
Allosteric regulation
In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.
See Allosteric modulator and Allosteric regulation
Alprazolam
Alprazolam, sold under the brand name Xanax and others, is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines.
See Allosteric modulator and Alprazolam
AMPA receptor
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate (iGluR) and predominantly Na+ ion channel that mediates fast synaptic transmission in the central nervous system (CNS).
See Allosteric modulator and AMPA receptor
AMPA receptor positive allosteric modulator
AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPR), a type of ionotropic glutamate receptor which mediates most fast synaptic neurotransmission in the central nervous system.
See Allosteric modulator and AMPA receptor positive allosteric modulator
Aniracetam
Aniracetam (brand names Draganon, Sarpul, Ampamet, Memodrin, Referan), also known as N-anisoyl-2-pyrrolidinone, is a racetam which is sold in Europe as a prescription drug.
See Allosteric modulator and Aniracetam
Barbiturate
Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid.
See Allosteric modulator and Barbiturate
Benzodiazepine
Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
See Allosteric modulator and Benzodiazepine
Biochemistry
Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms.
See Allosteric modulator and Biochemistry
Calcium-sensing receptor
The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ions.
See Allosteric modulator and Calcium-sensing receptor
CCR5
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.
See Allosteric modulator and CCR5
Chemical specificity
Chemical specificity is the ability of binding site of a macromolecule (such as a protein) to bind specific ligands.
See Allosteric modulator and Chemical specificity
Chlordiazepoxide
Chlordiazepoxide, trade name Librium among others, is a sedative and hypnotic medication of the benzodiazepine class; it is used to treat anxiety, insomnia and symptoms of withdrawal from alcohol, benzodiazepines, and other drugs.
See Allosteric modulator and Chlordiazepoxide
Cinacalcet
Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat primary hyperparathyroidism, tertiary hyperparathyroidism and parathyroid carcinoma.
See Allosteric modulator and Cinacalcet
Concentration
In chemistry, concentration is the abundance of a constituent divided by the total volume of a mixture.
See Allosteric modulator and Concentration
Conformational isomerism
In chemistry, conformational isomerism is a form of stereoisomerism in which the isomers can be interconverted just by rotations about formally single bonds (refer to figure on single bond rotation).
See Allosteric modulator and Conformational isomerism
CX614
CX-614 is an ampakine drug developed by Cortex Pharmaceuticals.
See Allosteric modulator and CX614
Cyclothiazide
Cyclothiazide (Anhydron, Acquirel, Doburil, Fluidil, Renazide, Tensodiural, Valmiran), sometimes abbreviated CTZ, is a benzothiadiazide (thiazide) diuretic and antihypertensive that was originally introduced in the United States in 1963 by Eli Lilly and was subsequently also marketed in Europe and Japan.
See Allosteric modulator and Cyclothiazide
Desensitization (medicine)
In medicine, desensitization is a method to reduce or eliminate an organism's negative reaction to a substance or stimulus.
See Allosteric modulator and Desensitization (medicine)
Diazepam
Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic.
See Allosteric modulator and Diazepam
Dipraglurant
Dipraglurant (INN) (code name ADX-48621) is a negative allosteric modulator of the mGlu5 receptor which is under development by Addex Therapeutics for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID).
See Allosteric modulator and Dipraglurant
Dopamine receptor D1
Dopamine receptor D1, also known as DRD1.
See Allosteric modulator and Dopamine receptor D1
Dose–response relationship
The dose–response relationship, or exposure–response relationship, describes the magnitude of the response of an organism, as a function of exposure (or doses) to a stimulus or stressor (usually a chemical) after a certain exposure time.
See Allosteric modulator and Dose–response relationship
Drug overdose
A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended.
See Allosteric modulator and Drug overdose
Evolution
Evolution is the change in the heritable characteristics of biological populations over successive generations.
See Allosteric modulator and Evolution
Fenobam
Fenobam is an imidazole derivative developed by McNeil Laboratories in the late 1970s as a novel anxiolytic drug with an at-the-time-unidentified molecular target in the brain.
See Allosteric modulator and Fenobam
GABAA receptor
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
See Allosteric modulator and GABAA receptor
GABAA receptor negative allosteric modulator
A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).
See Allosteric modulator and GABAA receptor negative allosteric modulator
GABAA receptor positive allosteric modulator
In pharmacology, GABAA receptor positive allosteric modulators, also known as GABAkines or GABAA receptor potentiators, are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system.
See Allosteric modulator and GABAA receptor positive allosteric modulator
Glutamic acid
Glutamic acid (symbol Glu or E; the anionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins.
See Allosteric modulator and Glutamic acid
Intrinsic activity
Intrinsic activity (IA) and efficacy refer to the relative ability of a drug-receptor complex to produce a maximum functional response.
See Allosteric modulator and Intrinsic activity
Ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.
See Allosteric modulator and Ion channel
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
See Allosteric modulator and Ligand (biochemistry)
Major depressive disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities.
See Allosteric modulator and Major depressive disorder
Maraviroc
Maraviroc, sold under the brand names Selzentry (US) and Celsentri (EU), is an antiretroviral medication used to treat HIV infection.
See Allosteric modulator and Maraviroc
Metabotropic glutamate receptor 5
Metabotropic glutamate receptor 5 is an excitatory Gq-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons.
See Allosteric modulator and Metabotropic glutamate receptor 5
Mevidalen
Mevidalen (developmental code name LY-3154207) is a dopaminergic drug which is under development for the treatment of Lewy body disease, including those with Parkinson's disease.
See Allosteric modulator and Mevidalen
Mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA.
See Allosteric modulator and Mutation
Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.
See Allosteric modulator and Neurotransmitter
Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine.
See Allosteric modulator and Nicotinic acetylcholine receptor
Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
See Allosteric modulator and Partial agonist
PH
In chemistry, pH, also referred to as acidity or basicity, historically denotes "potential of hydrogen" (or "power of hydrogen").
See Allosteric modulator and PH
Pharmacology
Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology.
See Allosteric modulator and Pharmacology
Phenobarbital
Phenobarbital, also known as phenobarbitone or phenobarb, sold under the brand name Luminal among others, is a medication of the barbiturate type.
See Allosteric modulator and Phenobarbital
Psychoactive drug
A psychoactive drug, mind-altering drug, or consciousness-altering drug is a chemical substance that changes brain function and results in alterations in perception, mood, consciousness, cognition, or behavior.
See Allosteric modulator and Psychoactive drug
Raseglurant
Raseglurant (INN) (code name ADX-10059) is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP which was under development by Addex Therapeutics for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety.
See Allosteric modulator and Raseglurant
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems.
See Allosteric modulator and Receptor (biochemistry)
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
See Allosteric modulator and Receptor antagonist
Research chemical
Research chemicals are chemical substances scientists use for medical and scientific research purposes.
See Allosteric modulator and Research chemical
Schizophrenia
Schizophrenia is a mental disorder characterized by reoccurring episodes of psychosis that are correlated with a general misperception of reality.
See Allosteric modulator and Schizophrenia
Signs and symptoms
Signs and symptoms are the observed or detectable signs, and experienced symptoms of an illness, injury, or condition.
See Allosteric modulator and Signs and symptoms
See also
Neuropharmacology
- Allosteric modulator
- American College of Neuropsychopharmacology
- Anabaseine
- Biohappiness
- Counterirritant
- Effects of long-term benzodiazepine use
- Ganglionic blocker
- Glycerophosphorylcholine
- List of psychiatric medications
- María Teresa Miras Portugal
- Miodrag Radulovacki
- Neuropharmacology
- Neuropharmacology (journal)
- Neuropsychopharmacology
- Neurotrophin mimetics
- OSU-6162
- Paradoxical disinhibition
- Psychiatric medication
- Psychopharmacology
- Psychoplastogen
- Reuptake inhibitor
- Reward dependence
- Ritalin class-action lawsuits
- Serotonin syndrome
- Synaptic pharmacology
- Uncoupling (neuropsychopharmacology)
References
Also known as Allosteric modulation, Negative allosteric modulation, Negative allosteric modulator, Negative allosteric modulators, Negative modulator, Negative modulators, Positive allosteric modulation, Positive allosteric modulator, Positive allosteric modulators, Positive modulator, Positive modulators.