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Index Alnespirone

Alnespirone (S-20,499) is a selective 5-HT1A receptor full agonist of the azapirone chemical class. [1]

8 relations: Agonist, Antidepressant, Anxiolytic, Azapirone, Binding selectivity, Chemical classification, 5-HT1A receptor, 8-OH-DPAT.


An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety.

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Azapirones are a class of drugs used as anxiolytics, antidepressants, and antipsychotics.

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Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Chemical classification

Chemical classification systems attempt to classify elements or compounds according to certain chemical functional or structural properties.

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5-HT1A receptor

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor.

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Redirects here:

S 20499, S-20499, S20499.


[1] https://en.wikipedia.org/wiki/Alnespirone

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